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Database: UniProt
Entry: Q9N2V2
LinkDB: Q9N2V2
Original site: Q9N2V2 
ID   NAS30_CAEEL             Reviewed;         685 AA.
AC   Q9N2V2;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-SEP-2011, sequence version 4.
DT   10-APR-2019, entry version 122.
DE   RecName: Full=Zinc metalloproteinase nas-30;
DE            EC=3.4.24.- {ECO:0000250|UniProtKB:A8Q2D1};
DE   AltName: Full=Nematode astacin 30;
DE   Flags: Precursor;
GN   Name=nas-30; ORFNames=Y95B8A.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   IDENTIFICATION, AND NOMENCLATURE.
RX   PubMed=14653817; DOI=10.1046/j.1432-1033.2003.03891.x;
RA   Moehrlen F., Hutter H., Zwilling R.;
RT   "The astacin protein family in Caenorhabditis elegans.";
RL   Eur. J. Biochem. 270:4909-4920(2003).
CC   -!- FUNCTION: Metalloprotease. {ECO:0000250|UniProtKB:A8Q2D1}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU01211};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000255|PROSITE-
CC       ProRule:PRU01211};
DR   EMBL; FO081787; CCD73556.1; -; Genomic_DNA.
DR   RefSeq; NP_490795.3; NM_058394.3.
DR   ProteinModelPortal; Q9N2V2; -.
DR   SMR; Q9N2V2; -.
DR   STRING; 6239.Y95B8A.1; -.
DR   MEROPS; M12.A46; -.
DR   EPD; Q9N2V2; -.
DR   PaxDb; Q9N2V2; -.
DR   PeptideAtlas; Q9N2V2; -.
DR   PRIDE; Q9N2V2; -.
DR   EnsemblMetazoa; Y95B8A.1; Y95B8A.1; WBGene00003548.
DR   GeneID; 190803; -.
DR   KEGG; cel:CELE_Y95B8A.1; -.
DR   UCSC; Y95B8A.1; c. elegans.
DR   CTD; 190803; -.
DR   WormBase; Y95B8A.1; CE52763; WBGene00003548; nas-30.
DR   eggNOG; KOG3714; Eukaryota.
DR   eggNOG; ENOG410ZPX7; LUCA.
DR   GeneTree; ENSGT00940000167997; -.
DR   InParanoid; Q9N2V2; -.
DR   OMA; ARIRIKI; -.
DR   OrthoDB; 681837at2759; -.
DR   PRO; PR:Q9N2V2; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00003548; Expressed in 3 organ(s), highest expression level in material anatomical entity.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd04280; ZnMc_astacin_like; 1.
DR   Gene3D; 2.60.120.290; -; 1.
DR   Gene3D; 3.40.390.10; -; 1.
DR   InterPro; IPR034035; Astacin-like_dom.
DR   InterPro; IPR000859; CUB_dom.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR001506; Peptidase_M12A.
DR   InterPro; IPR006026; Peptidase_Metallo.
DR   InterPro; IPR035914; Sperma_CUB_dom_sf.
DR   Pfam; PF01400; Astacin; 1.
DR   PRINTS; PR00480; ASTACIN.
DR   SMART; SM00042; CUB; 1.
DR   SMART; SM00235; ZnMc; 1.
DR   SUPFAM; SSF49854; SSF49854; 1.
DR   PROSITE; PS51864; ASTACIN; 1.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS00142; ZINC_PROTEASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Disulfide bond; EGF-like domain; Glycoprotein;
KW   Hydrolase; Metal-binding; Metalloprotease; Protease;
KW   Reference proteome; Zinc; Zymogen.
FT   PROPEP        1      ?       {ECO:0000305}.
FT                                /FTId=PRO_0000442677.
FT   CHAIN         ?    685       Zinc metalloproteinase nas-30.
FT                                /FTId=PRO_0000028934.
FT   DOMAIN      268    460       Peptidase M12A. {ECO:0000255|PROSITE-
FT                                ProRule:PRU01211}.
FT   DOMAIN      483    494       EGF-like.
FT   DOMAIN      494    612       CUB.
FT   COMPBIAS    109    151       Pro-rich.
FT   ACT_SITE    357    357       {ECO:0000255|PROSITE-ProRule:PRU01211}.
FT   METAL       356    356       Zinc; via tele nitrogen; catalytic.
FT                                {ECO:0000255|PROSITE-ProRule:PRU01211}.
FT   METAL       360    360       Zinc; via tele nitrogen; catalytic.
FT                                {ECO:0000255|PROSITE-ProRule:PRU01211}.
FT   METAL       366    366       Zinc; via tele nitrogen; catalytic.
FT                                {ECO:0000255|PROSITE-ProRule:PRU01211}.
FT   CARBOHYD    577    577       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID    308    459       {ECO:0000255|PROSITE-ProRule:PRU01211}.
FT   DISULFID    329    348       {ECO:0000255|PROSITE-ProRule:PRU01211}.
FT   DISULFID    463    483       {ECO:0000250}.
FT   DISULFID    485    494       {ECO:0000250}.
FT   DISULFID    506    527       {ECO:0000250}.
FT   DISULFID    554    574       {ECO:0000250}.
SQ   SEQUENCE   685 AA;  76192 MW;  840A6ACDB8931EB8 CRC64;
     MFQKLSFGTI LRVTRNTFFV SFFSLKFRFI PNIQIEMYMI QGCYIPAKSD KILETIFSDA
     PPVYRQPRTK AEKIERFRNI ARTFSPFVYE VNTTPAPHFD NFIWQQNAPA VTPEPFTFAP
     FSFPTLATVA PPAPGPGGPT LEPFLPTTAS PKLLAHNTAR MIREIASFSD GGRSRDQDFG
     AVQTLMQAFF EAVSSGNNGG AGAAAGAGTA LGDAPMLQAH RDGTELGANR ALTNKLFESD
     MVLTVKQMKA IVLAAQEARN PHGRKKRKVI TGSVYRWKSV IPFRFKGGDA KWKKLIREGL
     GLWEKETCVR WSENGPGKDY VIFFRGSGCY SSVGRTGGSQ LISIGYGCED KGIVAHEVGH
     SLGFWHEQSR PDRDDYIHLR KDWIIKGTDG NFEKRSWEEI EDMGVPYDVG SVMHYGSNAF
     TKDWDQITIE TKDSRYQGTI GQRQKLSFID VKQVNRLYCN SVCPVALPCM HGGYPDPNNC
     AVCKCPDGLG GKLCGRAAKG TDHDKCGGEL TATAEWQEMV YKGKRTCNWK VKSPSGGRVR
     LVLTELRYQC APACKAYIEI KHNTDFQQTG FRVCCFNKTY DVISDQSEAL ILSNANIVDY
     EVSYKLQWIQ DNGKALPPPK PTSTWVPGKE NRPFRGVENS GGTIEKFILQ AIPKIRDSHR
     PLESITSIVA EYGLATLLGI SHNGK
//
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