GenomeNet

Database: UniProt
Entry: Q9P7P8
LinkDB: Q9P7P8
Original site: Q9P7P8 
ID   DDH1_SCHPO              Reviewed;         332 AA.
AC   Q9P7P8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   16-JAN-2019, entry version 107.
DE   RecName: Full=2-hydroxyacid dehydrogenase homolog 1;
DE            EC=1.1.1.-;
GN   ORFNames=SPAC186.07c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales;
OC   Schizosaccharomycetaceae; Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
RA   Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
RA   Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
RA   Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
RA   James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
RA   Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
RA   Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
RA   Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
RA   Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
RA   Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
RA   Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
RA   Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
RA   Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
RA   Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
RA   Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
RA   Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
RA   Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
RA   Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
RA   Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
RA   Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
RA   Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
RA   Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
CC   -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC       dehydrogenase family. {ECO:0000305}.
DR   EMBL; CU329670; CAB75871.1; -; Genomic_DNA.
DR   PIR; T50134; T50134.
DR   RefSeq; NP_595025.1; NM_001020455.1.
DR   ProteinModelPortal; Q9P7P8; -.
DR   SMR; Q9P7P8; -.
DR   STRING; 4896.SPAC186.07c.1; -.
DR   PaxDb; Q9P7P8; -.
DR   PRIDE; Q9P7P8; -.
DR   EnsemblFungi; SPAC186.07c.1; SPAC186.07c.1:pep; SPAC186.07c.
DR   GeneID; 2542600; -.
DR   KEGG; spo:SPAC186.07c; -.
DR   EuPathDB; FungiDB:SPAC186.07c; -.
DR   PomBase; SPAC186.07c; -.
DR   HOGENOM; HOG000136695; -.
DR   InParanoid; Q9P7P8; -.
DR   OMA; SAFYTET; -.
DR   PhylomeDB; Q9P7P8; -.
DR   PRO; PR:Q9P7P8; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR   InterPro; IPR029753; D-isomer_DH_CS.
DR   InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00389; 2-Hacid_dh; 1.
DR   Pfam; PF02826; 2-Hacid_dh_C; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00670; D_2_HYDROXYACID_DH_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; NAD; Nucleus; Oxidoreductase;
KW   Reference proteome.
FT   CHAIN         1    332       2-hydroxyacid dehydrogenase homolog 1.
FT                                /FTId=PRO_0000316030.
FT   NP_BIND     154    155       NAD. {ECO:0000250}.
FT   NP_BIND     233    235       NAD. {ECO:0000250}.
FT   NP_BIND     296    299       NAD. {ECO:0000250}.
FT   ACT_SITE    235    235       {ECO:0000250}.
FT   ACT_SITE    264    264       {ECO:0000250}.
FT   ACT_SITE    296    296       Proton donor. {ECO:0000250}.
FT   BINDING     259    259       NAD. {ECO:0000250}.
SQ   SEQUENCE   332 AA;  36589 MW;  55D0127B63DDC00C CRC64;
     MRIAFFSAQP YEKEPFEKVN ENYKHEIDYH ESILNKKTAV LAEKAPVVCV FVNDKVDADT
     LKVLAKNGTK LIALRCAGFN NVDLKAAADN GITVVRVPAY SPYAVAEYTI GLLLSLNRKI
     HRAYVRVRED DFNLNGLLGH DLHGKTIGLL GTGRIGGLVA KCLKLGFGCE VLAHDIKPNK
     ELEKFGIQFV EQQEVLAKAD FLCLHCPLTP DTEHLVDEKL LASMKKGVKI INTSRGGLVD
     TKALVKAIES GQVGGCAMDV YEGERRLFYR DLSNEVIKDT TFQQLANFPN VLVTSHQAFF
     TAEALSAIAH TTLKNVSDFA SQNNDPSVIV KN
//
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