ID MLH1_SCHPO Reviewed; 684 AA.
AC Q9P7W6; P78862;
DT 29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 24-JAN-2024, entry version 150.
DE RecName: Full=Putative MutL protein homolog 1;
DE AltName: Full=DNA mismatch repair protein MLH1;
GN Name=mlh1; ORFNames=SPBC1703.04;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 305-684.
RC STRAIN=PR745;
RX PubMed=9501991; DOI=10.1093/dnares/4.6.363;
RA Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.;
RT "Identification of open reading frames in Schizosaccharomyces pombe
RT cDNAs.";
RL DNA Res. 4:363-369(1997).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA13873.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; CU329671; CAB66448.1; -; Genomic_DNA.
DR EMBL; D89212; BAA13873.1; ALT_FRAME; mRNA.
DR PIR; T43016; T43016.
DR PIR; T50317; T50317.
DR RefSeq; NP_596199.1; NM_001022118.2.
DR AlphaFoldDB; Q9P7W6; -.
DR SMR; Q9P7W6; -.
DR BioGRID; 276493; 43.
DR STRING; 284812.Q9P7W6; -.
DR MaxQB; Q9P7W6; -.
DR PaxDb; 4896-SPBC1703-04-1; -.
DR EnsemblFungi; SPBC1703.04.1; SPBC1703.04.1:pep; SPBC1703.04.
DR GeneID; 2539949; -.
DR KEGG; spo:SPBC1703.04; -.
DR PomBase; SPBC1703.04; mlh1.
DR VEuPathDB; FungiDB:SPBC1703.04; -.
DR eggNOG; KOG1979; Eukaryota.
DR HOGENOM; CLU_004131_2_0_1; -.
DR InParanoid; Q9P7W6; -.
DR OMA; ANYHVKK; -.
DR PhylomeDB; Q9P7W6; -.
DR Reactome; R-SPO-5358565; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha).
DR PRO; PR:Q9P7W6; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0044732; C:mitotic spindle pole body; HDA:PomBase.
DR GO; GO:0032389; C:MutLalpha complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0061982; P:meiosis I cell cycle process; IEA:UniProt.
DR GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03483; MutL_Trans_MLH1; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR032189; Mlh1_C.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF16413; Mlh1_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 2: Evidence at transcript level;
KW DNA damage; DNA repair; Nucleus; Reference proteome.
FT CHAIN 1..684
FT /note="Putative MutL protein homolog 1"
FT /id="PRO_0000178007"
SQ SEQUENCE 684 AA; 77254 MW; 7A59633B38E2944B CRC64;
MDVNSRAKIR PLDQLVINKI AAGEIIERPE NAIKELIENS LDAGSTSIDV LLKDGGLKLL
QITDNGSGIQ YDDLPYLCQR FSTSKIDNFN DLQHLQTFGF RGEALASISH VAKVTVVTKL
SSDIHAWKAF YVDGALAPIS PGMSPAPQPC AGKQGTVITA EDLFYNVRSR KSALKNGSEE
FRRIMILVQK YAIHNDQVSF NCKKVGDTVA SLSLSSRLSK ADKIRHIYGP RVASHLRDFS
LGEGQSSIVG FSANGFISNA DFQDKKSNLI LFINNRLVES VELRHALEET YAKYLHKGAS
YFVYLSLNMS PEQLDVNVHP SKRIVHFLYD QEIATSICDK LGEILERTDT ERSYPLQAMI
PSISNTKNAE SSSQKAVRTY ENYLVRTDPR ERSIKSMLSD NFLQRSSNNY DNEIIEKVDS
ANSNKNATND IKDLQTEEIV EEGNSIDLES IKSLQKQVIN SMHVLATNIL TEHKYVGLVC
PTRRIAAVQH NIGLYVVDYG KLSYHLFYQI CLTEFGNYGE FVLETPLSIS DLFEIVNGDE
DKSESEKFTR LLVSRRDMLK DYFSISVTSG GLLTAVPMLS PKYHPPFEQL PLLISSLTPK
FFDWLDEKSC LNGIMKAIAK FYVPLPLSYE ESDVKSIRSL ESCLEDYLFP EFRRRVICPK
KVFEEKCIYQ ITSLPRLYNV FERC
//