ID Q9PG32_XYLFA Unreviewed; 530 AA.
AC Q9PG32;
DT 01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2000, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE RecName: Full=cyclic-guanylate-specific phosphodiesterase {ECO:0000256|ARBA:ARBA00012282};
DE EC=3.1.4.52 {ECO:0000256|ARBA:ARBA00012282};
GN OrderedLocusNames=XF_0470 {ECO:0000313|EMBL:AAF83280.1};
OS Xylella fastidiosa (strain 9a5c).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Xanthomonadales;
OC Xanthomonadaceae; Xylella.
OX NCBI_TaxID=160492 {ECO:0000313|EMBL:AAF83280.1, ECO:0000313|Proteomes:UP000000812};
RN [1] {ECO:0000313|EMBL:AAF83280.1, ECO:0000313|Proteomes:UP000000812}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=9a5c {ECO:0000313|EMBL:AAF83280.1,
RC ECO:0000313|Proteomes:UP000000812};
RX PubMed=10910347; DOI=10.1038/35018003;
RA Simpson A.J., Reinach F.C., Arruda P., Abreu F.A., Acencio M.,
RA Alvarenga R., Alves L.M., Araya J.E., Baia G.S., Baptista C.S.,
RA Barros M.H., Bonaccorsi E.D., Bordin S., Bove J.M., Briones M.R.,
RA Bueno M.R., Camargo A.A., Camargo L.E., Carraro D.M., Carrer H.,
RA Colauto N.B., Colombo C., Costa F.F., Costa M.C., Costa-Neto C.M.,
RA Coutinho L.L., Cristofani M., Dias-Neto E., Docena C., El-Dorry H.,
RA Facincani A.P., Ferreira A.J., Ferreira V.C., Ferro J.A., Fraga J.S.,
RA Franca S.C., Franco M.C., Frohme M., Furlan L.R., Garnier M., Goldman G.H.,
RA Goldman M.H., Gomes S.L., Gruber A., Ho P.L., Hoheisel J.D.,
RA Junqueira M.L., Kemper E.L., Kitajima J.P., Krieger J.E., Kuramae E.E.,
RA Laigret F., Lambais M.R., Leite L.C., Lemos E.G., Lemos M.V., Lopes S.A.,
RA Lopes C.R., Machado J.A., Machado M.A., Madeira A.M., Madeira H.M.,
RA Marino C.L., Marques M.V., Martins E.A., Martins E.M., Matsukuma A.Y.,
RA Menck C.F., Miracca E.C., Miyaki C.Y., Monteriro-Vitorello C.B., Moon D.H.,
RA Nagai M.A., Nascimento A.L., Netto L.E., Nhani A.Jr., Nobrega F.G.,
RA Nunes L.R., Oliveira M.A., de Oliveira M.C., de Oliveira R.C.,
RA Palmieri D.A., Paris A., Peixoto B.R., Pereira G.A., Pereira H.A.Jr.,
RA Pesquero J.B., Quaggio R.B., Roberto P.G., Rodrigues V., de M Rosa A.J.,
RA de Rosa V.E.Jr., de Sa R.G., Santelli R.V., Sawasaki H.E., da Silva A.C.,
RA da Silva A.M., da Silva F.R., da Silva W.A.Jr., da Silveira J.F.,
RA Silvestri M.L., Siqueira W.J., de Souza A.A., de Souza A.P., Terenzi M.F.,
RA Truffi D., Tsai S.M., Tsuhako M.H., Vallada H., Van Sluys M.A.,
RA Verjovski-Almeida S., Vettore A.L., Zago M.A., Zatz M., Meidanis J.,
RA Setubal J.C.;
RT "The genome sequence of the plant pathogen Xylella fastidiosa.";
RL Nature 406:151-159(2000).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3',3'-c-di-GMP + H2O = 5'-phosphoguanylyl(3'->5')guanosine +
CC H(+); Xref=Rhea:RHEA:24902, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:58754, ChEBI:CHEBI:58805; EC=3.1.4.52;
CC Evidence={ECO:0000256|ARBA:ARBA00034290};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AE003849; AAF83280.1; -; Genomic_DNA.
DR PIR; H82801; H82801.
DR AlphaFoldDB; Q9PG32; -.
DR STRING; 160492.XF_0470; -.
DR KEGG; xfa:XF_0470; -.
DR eggNOG; COG4943; Bacteria.
DR HOGENOM; CLU_000445_131_1_6; -.
DR Proteomes; UP000000812; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0071111; F:cyclic-guanylate-specific phosphodiesterase activity; IEA:UniProtKB-EC.
DR CDD; cd01948; EAL; 1.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR InterPro; IPR024744; CSS-motif_dom.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR PANTHER; PTHR33121:SF56; CYCLIC DI-GMP PHOSPHODIESTERASE PDEB-RELATED; 1.
DR PANTHER; PTHR33121; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR Pfam; PF12792; CSS-motif; 1.
DR Pfam; PF00563; EAL; 1.
DR SMART; SM00052; EAL; 1.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR PROSITE; PS50883; EAL; 1.
PE 4: Predicted;
KW c-di-GMP {ECO:0000256|ARBA:ARBA00022636};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 248..269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 272..524
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
SQ SEQUENCE 530 AA; 59167 MW; 7B6C41BB14B6D3A6 CRC64;
MFSFRDSRLK RCWTLIVGAT LCIACLSVSV ALTDDYVWVT TQRHEQQRLR DLAQQMGQRV
DRAVSESLLL LSDMDHAHLA PCSPEHIARM RALVLATRYI TELDYASTQK LSCTSWGPFD
GALKQTLTSD TRNDGLELVK RVSLPLNPEQ RLLGLHHGDY HALMKLSTFM DFPIPPGVEL
ALATMDGVLL LSTGSHVKEL FGNPVNQPAS DPSHDVVAAR IQNPHHDWQI AVIEPIQQLV
GAVHRKEWLA IPVALLVSLS VSGLAILYLR RRRAPLTRLR QAIQRCEFFV CYQPIVSLSD
GRCVGAEALV RWRQQDGTLI LPDQFIPLAE RSGLILPITD QVIAASMREL GPLLVADRSL
HIAINVSVKD IESGRLLDVL ALALQDTGLY RKQLWIEATE RSFMDARAAR EHIVRLREAG
YAVVIDDFGT GYSNLQYLQQ LPLDALKIDK SFIDTVGRDV TNTAVASHII DIAKELGMRT
IAEGVEREEQ LTYLRARGVD MAQGWLFSSP LSAAEFVDYL ARNRSMQSDG
//
