ID Q9PTS6_DANRE Unreviewed; 199 AA.
AC Q9PTS6; A0A0R4IZ81; A0A8N7XJ84; F6NKM6;
DT 01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2000, sequence version 1.
DT 27-MAR-2024, entry version 125.
DE SubName: Full=Chico {ECO:0000313|EMBL:AAH97097.1, ECO:0000313|Ensembl:ENSDARP00000007256, ECO:0000313|RefSeq:NP_001299614.1};
GN Name=chico {ECO:0000313|EMBL:AAH97097.1,
GN ECO:0000313|Ensembl:ENSDARP00000007256,
GN ECO:0000313|RefSeq:NP_001299614.1, ECO:0000313|RefSeq:NP_570986.1,
GN ECO:0000313|ZFIN:ZDB-GENE-000210-28};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH97097.1};
RN [1] {ECO:0000313|EMBL:AAF21788.1}
RP NUCLEOTIDE SEQUENCE.
RA Nimer S.D., Zon L., Deblasio T.;
RT "Isolation and characterization of a novel member of the groucho family of
RT transcriptional repressors in zebrafish.";
RL Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|RefSeq:NP_001299614.1, ECO:0000313|RefSeq:NP_570986.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001299614.1,
RC ECO:0000313|RefSeq:NP_570986.1};
RX PubMed=12477932; DOI=10.1073/pnas.242603899;
RG Mammalian Gene Collection Program Team;
RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., Klausner R.D.,
RA Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., Altschul S.F.,
RA Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., Hopkins R.F., Jordan H.,
RA Moore T., Max S.I., Wang J., Hsieh F., Diatchenko L., Marusina K.,
RA Farmer A.A., Rubin G.M., Hong L., Stapleton M., Soares M.B., Bonaldo M.F.,
RA Casavant T.L., Scheetz T.E., Brownstein M.J., Usdin T.B., Toshiyuki S.,
RA Carninci P., Prange C., Raha S.S., Loquellano N.A., Peters G.J.,
RA Abramson R.D., Mullahy S.J., Bosak S.A., McEwan P.J., McKernan K.J.,
RA Malek J.A., Gunaratne P.H., Richards S., Worley K.C., Hale S., Garcia A.M.,
RA Gay L.J., Hulyk S.W., Villalon D.K., Muzny D.M., Sodergren E.J., Lu X.,
RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA Sanchez A., Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., Rodriguez A.C.,
RA Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Krzywinski M.I.,
RA Skalska U., Smailus D.E., Schnerch A., Schein J.E., Jones S.J., Marra M.A.;
RT "Generation and initial analysis of more than 15,000 full-length human and
RT mouse cDNA sequences.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
RN [3] {ECO:0000313|EMBL:AAH97097.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAH97097.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|RefSeq:NP_001299614.1, ECO:0000313|RefSeq:NP_570986.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001299614.1,
RC ECO:0000313|RefSeq:NP_570986.1};
RX PubMed=21873635;
RA Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.;
RT "Phylogenetic-based propagation of functional annotations within the Gene
RT Ontology consortium.";
RL Brief. Bioinform. 12:449-462(2011).
RN [5] {ECO:0000313|Ensembl:ENSDARP00000007256}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000007256};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [6] {ECO:0000313|Ensembl:ENSDARP00000007256, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000007256};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [7] {ECO:0000313|RefSeq:NP_001299614.1, ECO:0000313|RefSeq:NP_570986.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001299614.1,
RC ECO:0000313|RefSeq:NP_570986.1};
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [8] {ECO:0000313|Ensembl:ENSDARP00000141688}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000141688};
RG Ensembl;
RL Submitted (NOV-2015) to UniProtKB.
RN [9] {ECO:0000313|RefSeq:NP_001299614.1, ECO:0000313|RefSeq:NP_570986.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001299614.1,
RC ECO:0000313|RefSeq:NP_570986.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the WD repeat Groucho/TLE family.
CC {ECO:0000256|ARBA:ARBA00005969}.
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DR EMBL; CABZ01042148; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CU570695; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CU571311; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF085218; AAF21788.1; -; mRNA.
DR EMBL; BC097097; AAH97097.1; -; mRNA.
DR RefSeq; NP_001299614.1; NM_001312685.1.
DR RefSeq; NP_570986.1; NM_130911.2.
DR STRING; 7955.ENSDARP00000141688; -.
DR PaxDb; 7955-ENSDARP00000007256; -.
DR Ensembl; ENSDART00000002241.7; ENSDARP00000007256.6; ENSDARG00000019588.7.
DR Ensembl; ENSDART00000160768.2; ENSDARP00000141688.1; ENSDARG00000019588.7.
DR GeneID; 30067; -.
DR KEGG; dre:30067; -.
DR AGR; ZFIN:ZDB-GENE-000210-28; -.
DR CTD; 30067; -.
DR ZFIN; ZDB-GENE-000210-28; chico.
DR eggNOG; KOG0639; Eukaryota.
DR OMA; GDTHQDD; -.
DR OrthoDB; 3147966at2759; -.
DR Proteomes; UP000000437; Chromosome 2.
DR Bgee; ENSDARG00000019588; Expressed in mature ovarian follicle and 22 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR InterPro; IPR005617; Groucho/TLE_N.
DR InterPro; IPR009146; Groucho_enhance.
DR PANTHER; PTHR10814; TRANSDUCIN-LIKE ENHANCER PROTEIN; 1.
DR PANTHER; PTHR10814:SF31; TRANSDUCIN-LIKE ENHANCER PROTEIN 4; 1.
DR Pfam; PF03920; TLE_N; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 18..131
FT /note="Groucho/TLE N-terminal Q-rich"
FT /evidence="ECO:0000259|Pfam:PF03920"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 175..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 26..53
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 199 AA; 22304 MW; 3597454578AB980F CRC64;
MMFPQARHSA SSQSTQPLKF TTSDSCDRIK DEFQFLQAQY HSLKLECDKL ASEKSEMQRH
YIMYYEMSYG LNIEMHKQAE IVKRLNGICA QVLPYLSQEH QQQVLGAIER AKQVTPPEMN
SIIRQQLQVH QLSQLQGLAL PMTPLPLGLT PPTLPAVTSS SGLLSLSSIL ASHAHLAKED
KSSRDAADGH RDEDADKSD
//
