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Database: UniProt
Entry: Q9PUE1_COLLI
LinkDB: Q9PUE1_COLLI
Original site: Q9PUE1_COLLI 
ID   Q9PUE1_COLLI            Unreviewed;       427 AA.
AC   Q9PUE1;
DT   01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2000, sequence version 1.
DT   31-JUL-2019, entry version 100.
DE   SubName: Full=Inward rectifier channel Kir 2.1 {ECO:0000313|EMBL:AAF06331.1};
DE   SubName: Full=Potassium channel, inwardly rectifying subfamily J, member 2 {ECO:0000313|EMBL:PKK25596.1};
GN   Name=KCNJ2 {ECO:0000313|EMBL:PKK25596.1};
GN   ORFNames=A306_00006255 {ECO:0000313|EMBL:PKK25596.1};
OS   Columba livia (Rock dove).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX   NCBI_TaxID=8932 {ECO:0000313|EMBL:AAF06331.1};
RN   [1] {ECO:0000313|EMBL:AAF06331.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Breed White King {ECO:0000313|EMBL:AAF06331.1};
RC   TISSUE=Vestibula {ECO:0000313|EMBL:AAF06331.1};
RX   PubMed=15316115; DOI=10.1152/physiolgenomics.00096.2004;
RA   Correia M.J., Wood T.G., Prusak D., Weng T., Rennie K.J., Wang H.Q.;
RT   "Molecular characterization of an inward rectifier channel (IKir)
RT   found in avian vestibular hair cells: cloning and expression of
RT   pKir2.1.";
RL   Physiol. Genomics 19:155-169(2004).
RN   [2] {ECO:0000313|EMBL:PKK25596.1, ECO:0000313|Proteomes:UP000053872}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Blood {ECO:0000313|EMBL:PKK25596.1};
RX   PubMed=23371554; DOI=10.1126/science.1230422;
RA   Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA   Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA   Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT   "Genomic diversity and evolution of the head crest in the rock
RT   pigeon.";
RL   Science 339:1063-1067(2013).
RN   [3] {ECO:0000313|EMBL:PKK25596.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Blood {ECO:0000313|EMBL:PKK25596.1};
RA   Holt C., Campbell M., Edelman N., Keays D., Kapusta A., Domyan E.,
RA   Suh A., Carleton J., Warren W., Yandell M., Gilbert M.T.,
RA   Shapiro M.D.;
RT   "Improved genome assembly and annotation for the rock pigeon (Columba
RT   livia).";
RL   Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   EMBL; AF192507; AAF06331.1; -; mRNA.
DR   EMBL; AKCR02000032; PKK25596.1; -; Genomic_DNA.
DR   RefSeq; NP_001277030.1; NM_001290101.1.
DR   GeneID; 102098318; -.
DR   KEGG; clv:102098318; -.
DR   CTD; 3759; -.
DR   KO; K04996; -.
DR   OrthoDB; 956263at2759; -.
DR   Proteomes; UP000053872; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR003271; K_chnl_inward-rec_Kir2.1.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR013673; K_chnl_inward-rec_Kir_N.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   PANTHER; PTHR11767:SF43; PTHR11767:SF43; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   Pfam; PF08466; IRK_N; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01324; KIR21CHANNEL.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000053872};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609, ECO:0000313|EMBL:PKK25596.1};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     83    107       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    156    181       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        1     47       IRK_N. {ECO:0000259|Pfam:PF08466}.
FT   DOMAIN       48    186       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      193    365       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION      386    427       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   SITE        172    172       Role in the control of polyamine-mediated
FT                                channel gating and in the blocking by
FT                                intracellular magnesium.
FT                                {ECO:0000256|PIRSR:PIRSR005465-1}.
SQ   SEQUENCE   427 AA;  48561 MW;  3371E7976BFEF384 CRC64;
     MGSVRTNRYS IVSSEEDGMK LATMAVANGF GNGKSKVHTR QQCRSRFVKK DGHCNVQFIN
     VGEKGQRYLA DIFTTCVDIR WRWMLVIFCL TFILSWLFFG CVFWLIALLH GDLENQENNK
     PCVSQVSSFT AAFLFSIETQ TTIGYGFRCV TDECPIAVFM VVFQSIVGCI IDAFIIGAVM
     AKMAKPKKRN ETLVFSHNAV VAMRDGKLCL MWRVGNLRKS HLVEAHVRAQ LLKSRITSEG
     EYIPLDQIDI NVGFDSGIDR IFLVSPITIV HEIDEDSPLY DLSKQDMDNA DFEIVVILEG
     MVEATAMTTQ CRSSYLANEI LWGHRYEPVL FEEKNYYKVD YSRFHKTYEV PNTPICSARD
     LAEKKYILSN ANSFCYENEV ALNSKEEDEI DTGVPESMST DTHPDMDHHN QAGVPLEPRP
     LRRESEI
//
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