GenomeNet

Database: UniProt
Entry: Q9Q932_RFVKA
LinkDB: Q9Q932_RFVKA
Original site: Q9Q932_RFVKA 
ID   Q9Q932_RFVKA            Unreviewed;        74 AA.
AC   Q9Q932;
DT   01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2000, sequence version 1.
DT   12-AUG-2020, entry version 50.
DE   SubName: Full=Gp039L {ECO:0000313|EMBL:AAF17921.1};
GN   Name=s039L {ECO:0000313|EMBL:AAF17921.1};
OS   Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain
OS   Kasza)).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Leporipoxvirus.
OX   NCBI_TaxID=10272 {ECO:0000313|Proteomes:UP000000868};
OH   NCBI_TaxID=9986; Oryctolagus cuniculus (Rabbit).
RN   [1] {ECO:0000313|EMBL:AAF17921.1, ECO:0000313|Proteomes:UP000000868}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Kasza {ECO:0000313|EMBL:AAF17921.1,
RC   ECO:0000313|Proteomes:UP000000868};
RX   PubMed=6323741;
RA   Delange A.M., Macaulay C., Block W., Mueller T., McFadden G.;
RT   "Tumorigenic poxviruses: construction of the composite physical map of the
RT   Shope fibroma virus genome.";
RL   J. Virol. 50:408-416(1984).
RN   [2] {ECO:0000313|Proteomes:UP000000868}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Kasza {ECO:0000313|Proteomes:UP000000868};
RX   PubMed=3023681;
RA   Upton C., McFadden G.;
RT   "Identification and nucleotide sequence of the thymidine kinase gene of
RT   Shope fibroma virus.";
RL   J. Virol. 60:920-927(1986).
RN   [3] {ECO:0000313|Proteomes:UP000000868}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Kasza {ECO:0000313|Proteomes:UP000000868};
RX   PubMed=3023828;
RA   Upton C., McFadden G.;
RT   "DNA sequence homology between the terminal inverted repeats of Shope
RT   fibroma virus and an endogenous cellular plasmid species.";
RL   Mol. Cell. Biol. 6:265-276(1986).
RN   [4] {ECO:0000313|Proteomes:UP000000868}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Kasza {ECO:0000313|Proteomes:UP000000868};
RX   PubMed=3014722; DOI=10.1016/0042-6822(86)90134-0;
RA   Upton C., McFadden G.;
RT   "Tumorigenic poxviruses: analysis of viral DNA sequences implicated in the
RT   tumorigenicity of Shope fibroma virus and malignant rabbit virus.";
RL   Virology 152:308-321(1986).
RN   [5] {ECO:0000313|Proteomes:UP000000868}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Kasza {ECO:0000313|Proteomes:UP000000868};
RX   PubMed=2820128; DOI=10.1016/0042-6822(87)90039-0;
RA   Upton C., DeLange A.M., McFadden G.;
RT   "Tumorigenic poxviruses: genomic organization and DNA sequence of the
RT   telomeric region of the Shope fibroma virus genome.";
RL   Virology 160:20-30(1987).
RN   [6] {ECO:0000313|Proteomes:UP000000868}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Kasza {ECO:0000313|Proteomes:UP000000868};
RX   PubMed=2842947; DOI=10.1016/0042-6822(88)90164-X;
RA   Upton C., Macen J.L., Maranchuk R.A., DeLange A.M., McFadden G.;
RT   "Tumorigenic poxviruses: fine analysis of the recombination junctions in
RT   malignant rabbit fibroma virus, a recombinant between Shope fibroma virus
RT   and myxoma virus.";
RL   Virology 166:229-239(1988).
RN   [7] {ECO:0000313|Proteomes:UP000000868}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Kasza {ECO:0000313|Proteomes:UP000000868};
RX   PubMed=2161144; DOI=10.1016/0042-6822(90)90013-H;
RA   Upton C., Opgenorth A., Traktman P., McFadden G.;
RT   "Identification and DNA sequence of the Shope fibroma virus DNA
RT   topoisomerase gene.";
RL   Virology 176:439-447(1990).
RN   [8] {ECO:0000313|Proteomes:UP000000868}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Kasza {ECO:0000313|Proteomes:UP000000868};
RX   PubMed=2219722; DOI=10.1016/0042-6822(90)90294-2;
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "The complete DNA sequence of vaccinia virus.";
RL   Virology 179:247-266(1990).
RN   [9] {ECO:0000313|Proteomes:UP000000868}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Kasza {ECO:0000313|Proteomes:UP000000868};
RX   PubMed=2173269; DOI=10.1016/0042-6822(90)90170-V;
RA   Chang W., Macaulay C., Hu S.L., Tam J.P., McFadden G.;
RT   "Tumorigenic poxviruses: characterization of the expression of an epidermal
RT   growth factor related gene in Shope fibroma virus.";
RL   Virology 179:926-930(1990).
RN   [10] {ECO:0000313|Proteomes:UP000000868}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Kasza {ECO:0000313|Proteomes:UP000000868};
RX   PubMed=1850261; DOI=10.1016/0006-291X(91)90929-2;
RA   Smith C.A., Davis T., Wignall J.M., Din W.S., Farrah T., Upton C.,
RA   McFadden G., Goodwin R.G.;
RT   "T2 open reading frame from the Shope fibroma virus encodes a soluble form
RT   of the TNF receptor.";
RL   Biochem. Biophys. Res. Commun. 176:335-342(1991).
RN   [11] {ECO:0000313|Proteomes:UP000000868}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Kasza {ECO:0000313|Proteomes:UP000000868};
RX   PubMed=1649507; DOI=10.1016/0042-6822(91)91009-6;
RA   Upton C., Stuart D., McFadden G.;
RT   "Identification and DNA sequence of the large subunit of the capping enzyme
RT   from Shope fibroma virus.";
RL   Virology 183:773-777(1991).
RN   [12] {ECO:0000313|EMBL:AAF17921.1, ECO:0000313|Proteomes:UP000000868}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Kasza {ECO:0000313|EMBL:AAF17921.1,
RC   ECO:0000313|Proteomes:UP000000868};
RX   PubMed=1660196; DOI=10.1016/0042-6822(91)90529-K;
RA   Strayer D.S., Jerng H.H., O'Connor K.;
RT   "Sequence and analysis of a portion of the genomes of Shope fibroma virus
RT   and malignant rabbit fibroma virus that is important for viral replication
RT   in lymphocytes.";
RL   Virology 185:585-595(1991).
RN   [13] {ECO:0000313|Proteomes:UP000000868}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Kasza {ECO:0000313|Proteomes:UP000000868};
RX   PubMed=1331293;
RA   Massung R.F., McFadden G., Moyer R.W.;
RT   "Nucleotide sequence analysis of a unique near-terminal region of the
RT   tumorigenic poxvirus, Shope fibroma virus.";
RL   J. Gen. Virol. 73:2903-2911(1992).
RN   [14] {ECO:0000313|Proteomes:UP000000868}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Kasza {ECO:0000313|Proteomes:UP000000868};
RX   PubMed=1329373; DOI=10.1016/0168-1702(92)90104-H;
RA   Strayer D.S., Jerng H.H.;
RT   "Sequence and analysis of the BamHI 'D' fragment of Shope fibroma virus:
RT   comparison with similar regions of related poxviruses.";
RL   Virus Res. 25:117-132(1992).
RN   [15] {ECO:0000313|Proteomes:UP000000868}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Kasza {ECO:0000313|Proteomes:UP000000868};
RX   PubMed=8389453; DOI=10.1073/pnas.90.10.4518;
RA   Upton C., Stuart D.T., McFadden G.;
RT   "Identification of a poxvirus gene encoding a uracil-DNA glycosylase.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:4518-4522(1993).
RN   [16] {ECO:0000313|Proteomes:UP000000868}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Kasza {ECO:0000313|Proteomes:UP000000868};
RX   PubMed=8207794;
RA   Upton C., Schiff L., Rice S.A., Dowdeswell T., Yang X., McFadden G.;
RT   "A poxvirus protein with a RING finger motif binds zinc and localizes in
RT   virus factories.";
RL   J. Virol. 68:4186-4195(1994).
RN   [17] {ECO:0000313|Proteomes:UP000000868}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Kasza {ECO:0000313|Proteomes:UP000000868};
RX   PubMed=8030229; DOI=10.1006/viro.1994.1385;
RA   Parks R.J., Lichty B.D., Karakis C., Evans D.H.;
RT   "Characterization of the Shope fibroma virus DNA ligase gene.";
RL   Virology 202:642-650(1994).
RN   [18] {ECO:0000313|Proteomes:UP000000868}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Kasza {ECO:0000313|Proteomes:UP000000868};
RX   PubMed=7831813; DOI=10.1016/S0042-6822(95)80074-3;
RA   Mossman K., Ostergaard H., Upton C., McFadden G.;
RT   "Myxoma virus and Shope fibroma virus encode dual-specificity
RT   tyrosine/serine phosphatases which are essential for virus viability.";
RL   Virology 206:572-582(1995).
RN   [19] {ECO:0000313|Proteomes:UP000000868}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Kasza {ECO:0000313|Proteomes:UP000000868};
RX   PubMed=7747448; DOI=10.1006/viro.1995.1208;
RA   Mossman K., Upton C., Buller R.M., McFadden G.;
RT   "Species specificity of ectromelia virus and vaccinia virus interferon-
RT   gamma binding proteins.";
RL   Virology 208:762-769(1995).
RN   [20] {ECO:0000313|Proteomes:UP000000868}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Kasza {ECO:0000313|Proteomes:UP000000868};
RX   PubMed=9123853; DOI=10.1006/viro.1996.8423;
RA   Graham K.A., Lalani A.S., Macen J.L., Ness T.L., Barry M., Liu L.Y.,
RA   Lucas A., Clark-Lewis I., Moyer R.W., McFadden G.;
RT   "The T1/35kDa family of poxvirus-secreted proteins bind chemokines and
RT   modulate leukocyte influx into virus-infected tissues.";
RL   Virology 229:12-24(1997).
RN   [21] {ECO:0000313|Proteomes:UP000000868}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Kasza {ECO:0000313|Proteomes:UP000000868};
RX   PubMed=10074403; DOI=10.1006/jmbi.1999.2586;
RA   Palaniyar N., Gerasimopoulos E., Evans D.H.;
RT   "Shope fibroma virus DNA topoisomerase catalyses holliday junction
RT   resolution and hairpin formation in vitro.";
RL   J. Mol. Biol. 287:9-20(1999).
RN   [22] {ECO:0000313|Proteomes:UP000000868}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Kasza {ECO:0000313|Proteomes:UP000000868};
RX   PubMed=9971821;
RA   Jackson R.J., Hall D.F., Kerr P.J.;
RT   "Myxoma virus encodes an alpha2,3-sialyltransferase that enhances
RT   virulence.";
RL   J. Virol. 73:2376-2384(1999).
RN   [23] {ECO:0000313|EMBL:AAF17921.1, ECO:0000313|Proteomes:UP000000868}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Kasza {ECO:0000313|EMBL:AAF17921.1,
RC   ECO:0000313|Proteomes:UP000000868};
RX   PubMed=10562495; DOI=10.1006/viro.1999.0002;
RA   Willer D.O., McFadden G., Evans D.H.;
RT   "The complete genome sequence of shope (Rabbit) fibroma virus.";
RL   Virology 264:319-343(1999).
CC   -!- FUNCTION: Late protein which probably plays a role in virus entry into
CC       the host cell. {ECO:0000256|ARBA:ARBA00004101}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Virion membrane
CC       {ECO:0000256|ARBA:ARBA00004381}; Single-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004381}.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae I2 family.
CC       {ECO:0000256|ARBA:ARBA00007048}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF170722; AAF17921.1; -; Genomic_DNA.
DR   RefSeq; NP_051928.1; NC_001266.1.
DR   GeneID; 1486882; -.
DR   KEGG; vg:1486882; -.
DR   Proteomes; UP000000868; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR009175; Poxvirus_I2.
DR   Pfam; PF12575; Pox_EPC_I2-L1; 1.
DR   PIRSF; PIRSF003766; VAC_I2L; 1.
PE   3: Inferred from homology;
KW   Late protein {ECO:0000256|ARBA:ARBA00022921};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000868};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Viral penetration into host cytoplasm {ECO:0000256|ARBA:ARBA00022595};
KW   Virion {ECO:0000256|ARBA:ARBA00022844};
KW   Virus entry into host cell {ECO:0000256|ARBA:ARBA00022595}.
FT   TRANSMEM        47..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   74 AA;  8626 MW;  7D296A12C7835445 CRC64;
     MDRLYTALFG VFMTSTDDDF NNFIEVVKSV LTDKKSYTSG ISNGTRWWLV IITVVMVICL
     VFFLTMYLKV TRRN
//
DBGET integrated database retrieval system