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Database: UniProt
Entry: Q9RSY5
LinkDB: Q9RSY5
Original site: Q9RSY5 
ID   KITH_DEIRA              Reviewed;         212 AA.
AC   Q9RSY5;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   16-JAN-2019, entry version 97.
DE   RecName: Full=Thymidine kinase {ECO:0000255|HAMAP-Rule:MF_00124};
DE            EC=2.7.1.21 {ECO:0000255|HAMAP-Rule:MF_00124};
GN   Name=tdk {ECO:0000255|HAMAP-Rule:MF_00124}; OrderedLocusNames=DR_1984;
OS   Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 /
OS   LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422).
OC   Bacteria; Deinococcus-Thermus; Deinococci; Deinococcales;
OC   Deinococcaceae; Deinococcus.
OX   NCBI_TaxID=243230;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 /
RC   NCIMB 9279 / R1 / VKM B-1422;
RX   PubMed=10567266; DOI=10.1126/science.286.5444.1571;
RA   White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D.,
RA   Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L.,
RA   Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M.,
RA   Vamathevan J.J., Lam P., McDonald L.A., Utterback T.R., Zalewski C.,
RA   Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D.,
RA   Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C.,
RA   Fraser C.M.;
RT   "Genome sequence of the radioresistant bacterium Deinococcus
RT   radiodurans R1.";
RL   Science 286:1571-1577(1999).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + thymidine = ADP + dTMP + H(+);
CC         Xref=Rhea:RHEA:19129, ChEBI:CHEBI:15378, ChEBI:CHEBI:17748,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:63528, ChEBI:CHEBI:456216;
CC         EC=2.7.1.21; Evidence={ECO:0000255|HAMAP-Rule:MF_00124};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000255|HAMAP-Rule:MF_00124}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00124}.
CC   -!- SIMILARITY: Belongs to the thymidine kinase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00124}.
DR   EMBL; AE000513; AAF11536.1; -; Genomic_DNA.
DR   PIR; C75330; C75330.
DR   RefSeq; NP_295707.1; NC_001263.1.
DR   RefSeq; WP_010888617.1; NC_001263.1.
DR   ProteinModelPortal; Q9RSY5; -.
DR   SMR; Q9RSY5; -.
DR   STRING; 243230.DR_1984; -.
DR   EnsemblBacteria; AAF11536; AAF11536; DR_1984.
DR   GeneID; 1800380; -.
DR   KEGG; dra:DR_1984; -.
DR   PATRIC; fig|243230.17.peg.2207; -.
DR   eggNOG; ENOG4107104; Bacteria.
DR   eggNOG; COG1435; LUCA.
DR   HOGENOM; HOG000076390; -.
DR   InParanoid; Q9RSY5; -.
DR   KO; K00857; -.
DR   OMA; KEQFGWI; -.
DR   OrthoDB; 1279539at2; -.
DR   BRENDA; 2.7.1.21; 1856.
DR   Proteomes; UP000002524; Chromosome I.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004797; F:thymidine kinase activity; IBA:GO_Central.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006259; P:DNA metabolic process; IBA:GO_Central.
DR   GO; GO:0046104; P:thymidine metabolic process; IBA:GO_Central.
DR   HAMAP; MF_00124; Thymidine_kinase; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001267; Thymidine_kinase.
DR   PANTHER; PTHR11441; PTHR11441; 1.
DR   Pfam; PF00265; TK; 1.
DR   PIRSF; PIRSF035805; TK_cell; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA synthesis; Kinase;
KW   Nucleotide-binding; Reference proteome; Transferase.
FT   CHAIN         1    212       Thymidine kinase.
FT                                /FTId=PRO_0000174970.
FT   NP_BIND      16     23       ATP. {ECO:0000255|HAMAP-Rule:MF_00124}.
FT   NP_BIND      99    102       ATP. {ECO:0000255|HAMAP-Rule:MF_00124}.
FT   ACT_SITE    100    100       Proton acceptor. {ECO:0000255|HAMAP-
FT                                Rule:MF_00124}.
SQ   SEQUENCE   212 AA;  22398 MW;  5ACD76A28C6F88A8 CRC64;
     MLRSPYSGGH LEVVVGPMFS GKSEELIRRL TRSLIARQRV AVFKPAIDNR YHASEVASHA
     GRTLEAVAVP DAQAIRAQLS GQGELLSAAP EGVDVIGIDE AQFFGPELVP LVLELADAGV
     RVVLAGLDLD FRAEPFGSMP ELLARAESVD KLTAICTVCG APATRTQRLI GGQPARFDDP
     VVLVGAQESY EALPRAPHRA QGGVTTPSPL AS
//
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