ID UVRC_DEIRA Reviewed; 617 AA.
AC Q9RUN0;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 27-MAR-2024, entry version 117.
DE RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=DR_1354;
OS Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / CCUG
OS 27074 / LMG 4051 / NBRC 15346 / NCIMB 9279 / VKM B-1422 / R1).
OC Bacteria; Deinococcota; Deinococci; Deinococcales; Deinococcaceae;
OC Deinococcus.
OX NCBI_TaxID=243230;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / CCUG 27074 / LMG 4051 / NBRC
RC 15346 / NCIMB 9279 / VKM B-1422 / R1;
RX PubMed=10567266; DOI=10.1126/science.286.5444.1571;
RA White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D.,
RA Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L.,
RA Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M.,
RA Vamathevan J.J., Lam P., McDonald L.A., Utterback T.R., Zalewski C.,
RA Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D.,
RA Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C.,
RA Fraser C.M.;
RT "Genome sequence of the radioresistant bacterium Deinococcus radiodurans
RT R1.";
RL Science 286:1571-1577(1999).
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC lesion. The N-terminal half is responsible for the 3' incision and the
CC C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC Rule:MF_00203}.
CC -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC {ECO:0000255|HAMAP-Rule:MF_00203}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC Rule:MF_00203}.
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DR EMBL; AE000513; AAF10924.1; -; Genomic_DNA.
DR PIR; C75407; C75407.
DR RefSeq; NP_295077.1; NC_001263.1.
DR RefSeq; WP_010887995.1; NZ_JMLF01000006.1.
DR PDB; 8B0Q; X-ray; 1.80 A; A=366-617.
DR PDBsum; 8B0Q; -.
DR AlphaFoldDB; Q9RUN0; -.
DR SMR; Q9RUN0; -.
DR STRING; 243230.DR_1354; -.
DR PaxDb; 243230-DR_1354; -.
DR EnsemblBacteria; AAF10924; AAF10924; DR_1354.
DR GeneID; 69517599; -.
DR KEGG; dra:DR_1354; -.
DR PATRIC; fig|243230.17.peg.1551; -.
DR eggNOG; COG0322; Bacteria.
DR HOGENOM; CLU_014841_3_2_0; -.
DR InParanoid; Q9RUN0; -.
DR OrthoDB; 9804933at2; -.
DR Proteomes; UP000002524; Chromosome I.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006974; P:DNA damage response; IBA:GO_Central.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR CDD; cd10434; GIY-YIG_UvrC_Cho; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.1440.10; GIY-YIG endonuclease; 1.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR Gene3D; 3.30.420.340; UvrC, RNAse H endonuclease domain; 1.
DR HAMAP; MF_00203; UvrC; 1.
DR InterPro; IPR000305; GIY-YIG_endonuc.
DR InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR InterPro; IPR047296; GIY-YIG_UvrC_Cho.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR001943; UVR_dom.
DR InterPro; IPR036876; UVR_dom_sf.
DR InterPro; IPR004791; UvrC.
DR InterPro; IPR001162; UvrC_RNase_H_dom.
DR InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR NCBIfam; TIGR00194; uvrC; 1.
DR PANTHER; PTHR30562:SF1; UVRABC SYSTEM PROTEIN C; 1.
DR PANTHER; PTHR30562; UVRC/OXIDOREDUCTASE; 1.
DR Pfam; PF01541; GIY-YIG; 1.
DR Pfam; PF14520; HHH_5; 1.
DR Pfam; PF02151; UVR; 1.
DR Pfam; PF08459; UvrC_RNaseH_dom; 1.
DR SMART; SM00465; GIYc; 1.
DR SUPFAM; SSF46600; C-terminal UvrC-binding domain of UvrB; 1.
DR SUPFAM; SSF82771; GIY-YIG endonuclease; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
DR PROSITE; PS50164; GIY_YIG; 1.
DR PROSITE; PS50151; UVR; 1.
DR PROSITE; PS50165; UVRC; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; DNA damage; DNA excision; DNA repair;
KW Excision nuclease; Reference proteome; SOS response.
FT CHAIN 1..617
FT /note="UvrABC system protein C"
FT /id="PRO_0000227425"
FT DOMAIN 11..85
FT /note="GIY-YIG"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT DOMAIN 194..229
FT /note="UVR"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT HELIX 369..377
FT /evidence="ECO:0007829|PDB:8B0Q"
FT STRAND 386..396
FT /evidence="ECO:0007829|PDB:8B0Q"
FT STRAND 399..408
FT /evidence="ECO:0007829|PDB:8B0Q"
FT HELIX 414..416
FT /evidence="ECO:0007829|PDB:8B0Q"
FT STRAND 418..421
FT /evidence="ECO:0007829|PDB:8B0Q"
FT HELIX 430..441
FT /evidence="ECO:0007829|PDB:8B0Q"
FT HELIX 444..449
FT /evidence="ECO:0007829|PDB:8B0Q"
FT STRAND 454..460
FT /evidence="ECO:0007829|PDB:8B0Q"
FT HELIX 462..475
FT /evidence="ECO:0007829|PDB:8B0Q"
FT STRAND 481..484
FT /evidence="ECO:0007829|PDB:8B0Q"
FT STRAND 494..499
FT /evidence="ECO:0007829|PDB:8B0Q"
FT STRAND 504..507
FT /evidence="ECO:0007829|PDB:8B0Q"
FT HELIX 522..545
FT /evidence="ECO:0007829|PDB:8B0Q"
FT TURN 554..557
FT /evidence="ECO:0007829|PDB:8B0Q"
FT HELIX 563..569
FT /evidence="ECO:0007829|PDB:8B0Q"
FT TURN 570..572
FT /evidence="ECO:0007829|PDB:8B0Q"
FT HELIX 576..581
FT /evidence="ECO:0007829|PDB:8B0Q"
FT HELIX 584..588
FT /evidence="ECO:0007829|PDB:8B0Q"
FT HELIX 595..605
FT /evidence="ECO:0007829|PDB:8B0Q"
SQ SEQUENCE 617 AA; 68934 MW; CB01E574ABB6C293 CRC64;
MHFDDLPVLP TTPGVYIFRK GGVPIYIGKA NNLRSRVSQH FKAGGKSGKF TKLAESLEFI
SAANEVEALV LEANLIKQHR PHYNVLLKDD KHYPFLKLTN EAYPMLVVTR RVLKDGANYY
GPYPDASAVR RVKHLIDTMF PLRKNSGLPM QKKPRPCLNY HMGRCLGPCI DAAQPDEYRQ
AVEDVKALLE GRAAPVIARL KEDMKVAAQG QDFEQAARLR DRVQAVEKLF GTEQHAFVSE
ETDLDFLGAA QAGEFAMVQL FRMRGGRVVG RDKRFLTGAD ETGLGEIIGA FVADYYTQAT
HVPPLILLPA EYEDAALWSE FLSRQAGRRV EMRTPKRGDK TDLIEMAQRN AAVGLDSEMA
LLERRGDHPG LDALKDVLAL PERPWRIEGY DNSNLFGTNI VSGMVVFEGG RSRRGEHRRF
KVRGLEHPDD YESMKQTIYR RFTGSLADKL PLPDLMLIDG GRGQVNAALD ALKEAGVQVP
VVGLAKREER LILPGRYGAQ WWLETGTEVG VDRELLLPHT HPALRMLIGV RDEVHNYAVS
YHRKLRGEGM LRSVFDDLPG IGQKRRDALL EHFTSLEDLA AAPVEHIAAV PGMTLRAAQS
VKEFLQAREA QLPRAGG
//
