ID Q9U2U7_CAEEL Unreviewed; 308 AA.
AC Q9U2U7;
DT 01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2008, sequence version 2.
DT 24-JAN-2024, entry version 140.
DE RecName: Full=protein-ribulosamine 3-kinase {ECO:0000256|ARBA:ARBA00011961};
DE EC=2.7.1.172 {ECO:0000256|ARBA:ARBA00011961};
GN ORFNames=CELE_Y116A8C.25 {ECO:0000313|EMBL:CAB55130.2}, Y116A8C.25
GN {ECO:0000313|EMBL:CAB55130.2, ECO:0000313|WormBase:Y116A8C.25a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAB55130.2, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAB55130.2, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAB55130.2,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + N(6)-D-ribulosyl-L-lysyl-[protein] = ADP + H(+) + N(6)-
CC (3-O-phospho-D-ribulosyl)-L-lysyl-[protein]; Xref=Rhea:RHEA:48432,
CC Rhea:RHEA-COMP:12103, Rhea:RHEA-COMP:12104, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:90418, ChEBI:CHEBI:90420,
CC ChEBI:CHEBI:456216; EC=2.7.1.172;
CC Evidence={ECO:0000256|ARBA:ARBA00001616};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48433;
CC Evidence={ECO:0000256|ARBA:ARBA00001616};
CC -!- SIMILARITY: Belongs to the fructosamine kinase family.
CC {ECO:0000256|PIRNR:PIRNR006221}.
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DR EMBL; BX284604; CAB55130.2; -; Genomic_DNA.
DR RefSeq; NP_503025.2; NM_070624.2.
DR AlphaFoldDB; Q9U2U7; -.
DR SMR; Q9U2U7; -.
DR STRING; 6239.Y116A8C.25a.1; -.
DR PaxDb; 6239-Y116A8C-25; -.
DR EnsemblMetazoa; Y116A8C.25a.1; Y116A8C.25a.1; WBGene00013802.
DR GeneID; 191003; -.
DR UCSC; Y116A8C.25; c. elegans.
DR AGR; WB:WBGene00013802; -.
DR WormBase; Y116A8C.25a; CE42698; WBGene00013802; -.
DR eggNOG; KOG3021; Eukaryota.
DR GeneTree; ENSGT00390000005730; -.
DR HOGENOM; CLU_036517_0_1_1; -.
DR InParanoid; Q9U2U7; -.
DR OMA; YTAYHNK; -.
DR OrthoDB; 2101593at2759; -.
DR PhylomeDB; Q9U2U7; -.
DR Reactome; R-CEL-163841; Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00013802; Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues.
DR ExpressionAtlas; Q9U2U7; baseline and differential.
DR GO; GO:0016301; F:kinase activity; IBA:GO_Central.
DR GO; GO:0102193; F:protein-ribulosamine 3-kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.90.1200.10; -; 1.
DR InterPro; IPR016477; Fructo-/Ketosamine-3-kinase.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR PANTHER; PTHR12149; FRUCTOSAMINE 3 KINASE-RELATED PROTEIN; 1.
DR PANTHER; PTHR12149:SF8; PROTEIN-RIBULOSAMINE 3-KINASE; 1.
DR Pfam; PF03881; Fructosamin_kin; 2.
DR PIRSF; PIRSF006221; Ketosamine-3-kinase; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|PIRNR:PIRNR006221};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transferase {ECO:0000256|PIRNR:PIRNR006221}.
SQ SEQUENCE 308 AA; 35415 MW; 5E96EDF61562CC6C CRC64;
MDREVEAQIG LNNVKILKSN ILDSDEGKLF LKFGDEDLVI GELESLKAIQ STETILCPKP
FGIIRRNGSY SLITSYIDFQ LRKDWALAGS QLAKMHAKNG EQLAQNARRT RFVSVNSGMS
DISKSEEGEQ IGTENFGFHV TTCCGRLGQE NDWTETWEEF FIRHRLKPQI DRLIETHNDR
QLFELSEILY TKTAKLLKCR ENVLPSLVHG DLWGGNWSMT TADGAPEPII FDPSSSYSDP
EFEFGIMKMF GGWTQDFENK YEKIIKTADG KNQRVLLYEL YHNLNHWNHF GNSYRKSSID
LIKQILKF
//
