ID Q9U2X1_CAEEL Unreviewed; 362 AA.
AC Q9U2X1;
DT 01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT 25-NOV-2008, sequence version 2.
DT 27-MAR-2024, entry version 164.
DE SubName: Full=Pept_C1 domain-containing protein {ECO:0000313|EMBL:CAB54334.2};
GN ORFNames=CELE_Y113G7B.15 {ECO:0000313|EMBL:CAB54334.2}, Y113G7B.15
GN {ECO:0000313|EMBL:CAB54334.2, ECO:0000313|WormBase:Y113G7B.15};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAB54334.2, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAB54334.2, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAB54334.2,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR EMBL; BX284605; CAB54334.2; -; Genomic_DNA.
DR RefSeq; NP_507904.2; NM_075503.2.
DR AlphaFoldDB; Q9U2X1; -.
DR SMR; Q9U2X1; -.
DR DIP; DIP-25339N; -.
DR IntAct; Q9U2X1; 4.
DR STRING; 6239.Y113G7B.15.1; -.
DR MEROPS; C01.A47; -.
DR PaxDb; 6239-Y113G7B-15; -.
DR EnsemblMetazoa; Y113G7B.15.1; Y113G7B.15.1; WBGene00013764.
DR GeneID; 190976; -.
DR KEGG; cel:CELE_Y113G7B.15; -.
DR UCSC; Y113G7B.15; c. elegans.
DR AGR; WB:WBGene00013764; -.
DR WormBase; Y113G7B.15; CE43065; WBGene00013764; -.
DR eggNOG; KOG1543; Eukaryota.
DR GeneTree; ENSGT00970000196101; -.
DR HOGENOM; CLU_012184_1_0_1; -.
DR InParanoid; Q9U2X1; -.
DR OMA; PAEWHSV; -.
DR OrthoDB; 2879947at2759; -.
DR PhylomeDB; Q9U2X1; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00013764; Expressed in pharyngeal muscle cell (C elegans) and 1 other cell type or tissue.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0051603; P:proteolysis involved in protein catabolic process; IBA:GO_Central.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR PANTHER; PTHR12411:SF879; PROTEIN CBG12906; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Signal {ECO:0000256|SAM:SignalP};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..362
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018687363"
FT DOMAIN 30..90
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 131..359
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
FT REGION 91..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..111
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 362 AA; 41402 MW; C16116366780C8FF CRC64;
MLLFIISPLF LLSLCQPTVT QHSQEVLSHF NNFTMHHKKH YRTPAEKDRR LAHFAKNHQK
IQELNAKARR EGRNVTFGWN KFADKNRQEL SARNSKIHPK NHTDLPIYKP RHPRGSRNHH
NKRSKRQSGD IPDYFDLRDI YVDGSPVVGP VKDQEQCGCC WAFATTAITE AANTLYSKSF
TSLSDQEICD CADSGDTPGC VGGDPRNGLK MVHLRGQSSD GDYPYEEYRA NTTGNCVGDE
KSTVIQPETL NVYRFDQDYA EEDIMENLYL NHIPTAVYFR VGENFEWYTS GVLQSEDCYQ
MTPAEWHSVA IVGYGTSDDG VPYWLVRNSW NSDWGLHGYV KIRRGVNWCL IESHAATAMI
DN
//
