ID ZN212_HUMAN Reviewed; 495 AA.
AC Q9UDV6; B2RCF4; Q13396; Q8N664;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 3.
DT 27-MAR-2024, entry version 195.
DE RecName: Full=Zinc finger protein 212;
DE AltName: Full=Zinc finger protein C2H2-150;
GN Name=ZNF212; Synonyms=ZNFC150;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 140-495.
RX PubMed=9169157; DOI=10.1006/geno.1997.4678;
RA Becker K.G., Nagle J.W., Canning R.D., Dehejia A.M., Polymeropoulos M.H.,
RA Gado A.M., Biddison W.E., Drew P.D.;
RT "Molecular cloning and mapping of a novel human KRAB domain-containing
RT C2H2-type zinc finger to chromosome 7q36.1.";
RL Genomics 41:502-504(1997).
RN [6]
RP PARTIAL NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Hippocampus;
RX PubMed=7633419; DOI=10.1093/hmg/4.4.685;
RA Becker K.G., Nagle J.W., Canning R.D., Biddison W.E., Ozato K., Drew P.D.;
RT "Rapid isolation and characterization of 118 novel C2H2-type zinc finger
RT cDNAs expressed in human brain.";
RL Hum. Mol. Genet. 4:685-691(1995).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q9UDV6; Q13895: BYSL; NbExp=3; IntAct=EBI-1640204, EBI-358049;
CC Q9UDV6; Q96MY7: FAM161B; NbExp=3; IntAct=EBI-1640204, EBI-7225287;
CC Q9UDV6; Q86YD7: FAM90A1; NbExp=8; IntAct=EBI-1640204, EBI-6658203;
CC Q9UDV6; O95995: GAS8; NbExp=3; IntAct=EBI-1640204, EBI-1052570;
CC Q9UDV6; P13807: GYS1; NbExp=3; IntAct=EBI-1640204, EBI-740553;
CC Q9UDV6; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-1640204, EBI-2556193;
CC Q9UDV6; P55081: MFAP1; NbExp=3; IntAct=EBI-1640204, EBI-1048159;
CC Q9UDV6; P40692: MLH1; NbExp=3; IntAct=EBI-1640204, EBI-744248;
CC Q9UDV6; P54646: PRKAA2; NbExp=3; IntAct=EBI-1640204, EBI-1383852;
CC Q9UDV6; Q12874: SF3A3; NbExp=4; IntAct=EBI-1640204, EBI-1051880;
CC Q9UDV6; Q9H5I1: SUV39H2; NbExp=2; IntAct=EBI-1640204, EBI-723127;
CC Q9UDV6; Q9UDV6: ZNF212; NbExp=2; IntAct=EBI-1640204, EBI-1640204;
CC Q9UDV6; P17036: ZNF3; NbExp=4; IntAct=EBI-1640204, EBI-1640965;
CC Q9UDV6; Q6ZMS7: ZNF783; NbExp=5; IntAct=EBI-1640204, EBI-10254978;
CC Q9UDV6; Q6ZMS7-2: ZNF783; NbExp=3; IntAct=EBI-1640204, EBI-17789949;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC51296.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAD45826.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK315086; BAG37551.1; -; mRNA.
DR EMBL; AC004890; AAD45826.2; ALT_INIT; Genomic_DNA.
DR EMBL; CH471146; EAW80054.1; -; Genomic_DNA.
DR EMBL; BC022785; AAH22785.2; -; mRNA.
DR EMBL; U38864; AAC51296.1; ALT_INIT; mRNA.
DR CCDS; CCDS5896.1; -.
DR PIR; I39199; I39199.
DR RefSeq; NP_036388.2; NM_012256.3.
DR AlphaFoldDB; Q9UDV6; -.
DR SMR; Q9UDV6; -.
DR BioGRID; 113698; 52.
DR IntAct; Q9UDV6; 40.
DR MINT; Q9UDV6; -.
DR STRING; 9606.ENSP00000338572; -.
DR iPTMnet; Q9UDV6; -.
DR PhosphoSitePlus; Q9UDV6; -.
DR BioMuta; ZNF212; -.
DR DMDM; 55977888; -.
DR EPD; Q9UDV6; -.
DR jPOST; Q9UDV6; -.
DR MassIVE; Q9UDV6; -.
DR MaxQB; Q9UDV6; -.
DR PaxDb; 9606-ENSP00000338572; -.
DR PeptideAtlas; Q9UDV6; -.
DR ProteomicsDB; 84118; -.
DR Pumba; Q9UDV6; -.
DR Antibodypedia; 18581; 156 antibodies from 23 providers.
DR DNASU; 7988; -.
DR Ensembl; ENST00000335870.7; ENSP00000338572.2; ENSG00000170260.9.
DR GeneID; 7988; -.
DR KEGG; hsa:7988; -.
DR MANE-Select; ENST00000335870.7; ENSP00000338572.2; NM_012256.4; NP_036388.2.
DR UCSC; uc003wfp.3; human.
DR AGR; HGNC:13004; -.
DR CTD; 7988; -.
DR GeneCards; ZNF212; -.
DR HGNC; HGNC:13004; ZNF212.
DR HPA; ENSG00000170260; Low tissue specificity.
DR MIM; 602386; gene.
DR neXtProt; NX_Q9UDV6; -.
DR PharmGKB; PA37583; -.
DR VEuPathDB; HostDB:ENSG00000170260; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162364; -.
DR HOGENOM; CLU_002678_76_3_1; -.
DR InParanoid; Q9UDV6; -.
DR OMA; CMRSFSC; -.
DR OrthoDB; 4614113at2759; -.
DR PhylomeDB; Q9UDV6; -.
DR TreeFam; TF337777; -.
DR PathwayCommons; Q9UDV6; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q9UDV6; -.
DR BioGRID-ORCS; 7988; 60 hits in 1173 CRISPR screens.
DR ChiTaRS; ZNF212; human.
DR GenomeRNAi; 7988; -.
DR Pharos; Q9UDV6; Tdark.
DR PRO; PR:Q9UDV6; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q9UDV6; Protein.
DR Bgee; ENSG00000170260; Expressed in lower esophagus mucosa and 217 other cell types or tissues.
DR ExpressionAtlas; Q9UDV6; baseline and differential.
DR Genevisible; Q9UDV6; HS.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; NAS:UniProtKB.
DR GO; GO:0016358; P:dendrite development; IEA:Ensembl.
DR GO; GO:0051867; P:general adaptation syndrome, behavioral process; IEA:Ensembl.
DR GO; GO:0050885; P:neuromuscular process controlling balance; IEA:Ensembl.
DR GO; GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; NAS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0097305; P:response to alcohol; IEA:Ensembl.
DR GO; GO:0090659; P:walking behavior; IEA:Ensembl.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 4.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23232; KRAB DOMAIN C2H2 ZINC FINGER; 1.
DR PANTHER; PTHR23232:SF145; ZINC FINGER PROTEIN 746-RELATED; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 3.
DR Pfam; PF13912; zf-C2H2_6; 1.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..495
FT /note="Zinc finger protein 212"
FT /id="PRO_0000047456"
FT DOMAIN 141..219
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 316..338
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 369..391
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 427..449
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 455..477
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 264..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 337..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 476..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..290
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 293
FT /note="H -> Y (in dbSNP:rs34185245)"
FT /id="VAR_052794"
SQ SEQUENCE 495 AA; 55447 MW; AF0F7EEC8A482F8A CRC64;
MAESAPARHR RKRRSTPLTS STLPSQATEK SSYFQTTEIS LWTVVAAIQA VEKKMESQAA
RLQSLEGRTG TAEKKLADCE KMAVEFGNQL EGKWAVLGTL LQEYGLLQRR LENVENLLRN
RNFWILRLPP GSKGEAPKVS RSLENDGVCF TEQEWENLED WQKELYRNVM ESNYETLVSL
KVLGQTEGEA ELGTEMLGDL EEEGPGGAHP AGGVMIKQEL QYTQEGPADL PGEFSCIAEE
QAFLSPEQTE LWGGQGSSVL LETGPGDSTL EEPVGSRVPS SSRTVGCPKQ KSHRQVQLDQ
ECGQGLKLKK DTSRPYECSE CEITFRYKQQ LATHLRSHSG WGSCTPEEPE ESLRPRPRLK
PQTKKAKLHQ CDVCLRSFSC KVSLVTHQRC HLQEGPSAGQ HVQERFSPNS LVALPGHIPW
RKSRSSLICG YCGKSFSHPS DLVRHQRIHT GERPYSCTEC EKSFVQKQHL LQHQKIHQRE
RGGLALEPGR PNGLL
//
