GenomeNet

Database: UniProt
Entry: Q9UKN1
LinkDB: Q9UKN1
Original site: Q9UKN1 
ID   MUC12_HUMAN             Reviewed;        5478 AA.
AC   Q9UKN1; A6ND38; F5GWV9; Q9UKN0;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 2.
DT   13-FEB-2019, entry version 118.
DE   RecName: Full=Mucin-12;
DE            Short=MUC-12;
DE   AltName: Full=Mucin-11;
DE            Short=MUC-11;
DE   Flags: Precursor;
GN   Name=MUC12; Synonyms=MUC11;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 3283-4239 AND 4894-5478, AND TISSUE
RP   SPECIFICITY.
RC   TISSUE=Colon mucosa;
RX   PubMed=10463611;
RA   Williams S.J., McGuckin M.A., Gotley D.C., Eyre H.J., Sutherland G.R.,
RA   Antalis T.M.;
RT   "Two novel mucin genes down-regulated in colorectal cancer identified
RT   by differential display.";
RL   Cancer Res. 59:4083-4089(1999).
RN   [3]
RP   CLEAVAGE, AND MOTIF.
RX   PubMed=11341784; DOI=10.1006/bbrc.2001.4775;
RA   Parry S., Silverman H.S., McDermott K., Willis A., Hollingsworth M.A.,
RA   Harris A.;
RT   "Identification of MUC1 proteolytic cleavage sites in vivo.";
RL   Biochem. Biophys. Res. Commun. 283:715-720(2001).
RN   [4]
RP   INDUCTION.
RX   PubMed=15953034; DOI=10.1111/j.1462-5822.2005.00532.x;
RA   Lievin-Le Moal V., Servin A.L., Coconnier-Polter M.-H.;
RT   "The increase in mucin exocytosis and the upregulation of MUC genes
RT   encoding for membrane-bound mucins induced by the thiol-activated
RT   exotoxin listeriolysin O is a host cell defence response that inhibits
RT   the cell-entry of Listeria monocytogenes.";
RL   Cell. Microbiol. 7:1035-1048(2005).
RN   [5]
RP   CLEAVAGE, MOTIF, AND DOMAIN SEA.
RX   PubMed=15943821; DOI=10.1111/j.1742-4658.2005.04711.x;
RA   Palmai-Pallag T., Khodabukus N., Kinarsky L., Leir S.-H., Sherman S.,
RA   Hollingsworth M.A., Harris A.;
RT   "The role of the SEA (sea urchin sperm protein, enterokinase and
RT   agrin) module in cleavage of membrane-tethered mucins.";
RL   FEBS J. 272:2901-2911(2005).
RN   [6]
RP   FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=17058067; DOI=10.1007/s00109-006-0100-2;
RA   Moehle C., Ackermann N., Langmann T., Aslanidis C., Kel A.,
RA   Kel-Margoulis O., Schmitz-Madry A., Zahn A., Stremmel W., Schmitz G.;
RT   "Aberrant intestinal expression and allelic variants of mucin genes
RT   associated with inflammatory bowel disease.";
RL   J. Mol. Med. 84:1055-1066(2006).
CC   -!- FUNCTION: Involved in epithelial cell protection, adhesion
CC       modulation, and signaling. May be involved in epithelial cell
CC       growth regulation. Stimulated by both cytokine TNF-alpha and TGF-
CC       beta in intestinal epithelium. {ECO:0000269|PubMed:17058067}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9UKN1-1; Sequence=Displayed;
CC         Note=No experimental confirmation available.;
CC       Name=2;
CC         IsoId=Q9UKN1-2; Sequence=VSP_056721;
CC         Note=No experimental confirmation available.;
CC   -!- TISSUE SPECIFICITY: Ubiquitous, with higher expression in colon.
CC       Down-regulated in colorectal cancer as well as in the colon of
CC       patients with ulcerative colitis (UC) and Crohn's disease (CD).
CC       {ECO:0000269|PubMed:10463611, ECO:0000269|PubMed:17058067}.
CC   -!- INDUCTION: By listeriolysin O. {ECO:0000269|PubMed:15953034}.
CC   -!- DOMAIN: The proteolytic cleavage occurs within the SEA domain.
CC       This domain is not interchangeable, suggesting that it is
CC       insufficient to mediate efficient cleavage.
CC       {ECO:0000269|PubMed:15943821}.
CC   -!- MISCELLANEOUS: Infection by L.monocytogenes induces increases in
CC       mucin secretion and MUC4 and MUC12 transcription. This may
CC       constitute a host cell defense response that inhibits the entry of
CC       listeria monocytogenes in the cell.
CC   -!- WEB RESOURCE: Name=Mucin database;
CC       URL="http://www.medkem.gu.se/mucinbiology/databases/";
DR   EMBL; AC105446; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AF147790; AAD55678.1; -; mRNA.
DR   EMBL; AF147791; AAD55679.1; -; mRNA.
DR   CCDS; CCDS55139.1; -. [Q9UKN1-2]
DR   RefSeq; NP_001157934.1; NM_001164462.1. [Q9UKN1-2]
DR   UniGene; Hs.489355; -.
DR   ProteinModelPortal; Q9UKN1; -.
DR   BioGrid; 115382; 2.
DR   IntAct; Q9UKN1; 3.
DR   STRING; 9606.ENSP00000441929; -.
DR   iPTMnet; Q9UKN1; -.
DR   PhosphoSitePlus; Q9UKN1; -.
DR   BioMuta; MUC12; -.
DR   DMDM; 187609692; -.
DR   jPOST; Q9UKN1; -.
DR   PaxDb; Q9UKN1; -.
DR   PeptideAtlas; Q9UKN1; -.
DR   PRIDE; Q9UKN1; -.
DR   ProteomicsDB; 84823; -.
DR   Ensembl; ENST00000379442; ENSP00000368755; ENSG00000205277. [Q9UKN1-1]
DR   Ensembl; ENST00000536621; ENSP00000441929; ENSG00000205277. [Q9UKN1-2]
DR   GeneID; 10071; -.
DR   KEGG; hsa:10071; -.
DR   UCSC; uc003uxo.4; human. [Q9UKN1-1]
DR   CTD; 10071; -.
DR   DisGeNET; 10071; -.
DR   EuPathDB; HostDB:ENSG00000205277.9; -.
DR   GeneCards; MUC12; -.
DR   H-InvDB; HIX0201128; -.
DR   HGNC; HGNC:7510; MUC12.
DR   HPA; HPA023835; -.
DR   MIM; 604609; gene.
DR   neXtProt; NX_Q9UKN1; -.
DR   OpenTargets; ENSG00000205277; -.
DR   eggNOG; ENOG410IK1M; Eukaryota.
DR   eggNOG; ENOG41126RR; LUCA.
DR   GeneTree; ENSGT00940000165469; -.
DR   HOVERGEN; HBG099234; -.
DR   InParanoid; Q9UKN1; -.
DR   KO; K22018; -.
DR   OMA; AIASTHD; -.
DR   OrthoDB; 44585at2759; -.
DR   PhylomeDB; Q9UKN1; -.
DR   TreeFam; TF344108; -.
DR   Reactome; R-HSA-5083625; Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC).
DR   Reactome; R-HSA-5083632; Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS).
DR   Reactome; R-HSA-5083636; Defective GALNT12 causes colorectal cancer 1 (CRCS1).
DR   Reactome; R-HSA-5621480; Dectin-2 family.
DR   Reactome; R-HSA-913709; O-linked glycosylation of mucins.
DR   Reactome; R-HSA-977068; Termination of O-glycan biosynthesis.
DR   ChiTaRS; MUC12; human.
DR   GenomeRNAi; 10071; -.
DR   PRO; PR:Q9UKN1; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000205277; Expressed in 94 organ(s), highest expression level in mucosa of sigmoid colon.
DR   ExpressionAtlas; Q9UKN1; baseline and differential.
DR   Genevisible; Q9UKN1; HS.
DR   GO; GO:0005796; C:Golgi lumen; TAS:Reactome.
DR   GO; GO:0005887; C:integral component of plasma membrane; NAS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0016266; P:O-glycan processing; TAS:Reactome.
DR   GO; GO:0001558; P:regulation of cell growth; NAS:UniProtKB.
DR   GO; GO:0002223; P:stimulatory C-type lectin receptor signaling pathway; TAS:Reactome.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000082; SEA_dom.
DR   InterPro; IPR036364; SEA_dom_sf.
DR   Pfam; PF01390; SEA; 1.
DR   SUPFAM; SSF82671; SSF82671; 1.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50024; SEA; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Complete proteome; Disulfide bond;
KW   EGF-like domain; Glycoprotein; Membrane; Polymorphism;
KW   Reference proteome; Repeat; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL        1     16       {ECO:0000255}.
FT   CHAIN        17   5478       Mucin-12.
FT                                /FTId=PRO_0000331620.
FT   TOPO_DOM     17   5380       Extracellular. {ECO:0000255}.
FT   TRANSMEM   5381   5401       Helical. {ECO:0000255}.
FT   TOPO_DOM   5402   5478       Cytoplasmic. {ECO:0000255}.
FT   REPEAT      222    240       1.
FT   REPEAT      471    489       2.
FT   REPEAT      499    517       3.
FT   REPEAT      662    680       4.
FT   REPEAT      827    845       5.
FT   REPEAT     1159   1177       6.
FT   REPEAT     1466   1484       7.
FT   REPEAT     1633   1651       8.
FT   REPEAT     1717   1735       9.
FT   REPEAT     1882   1900       10.
FT   REPEAT     1910   1928       11.
FT   REPEAT     2075   2093       12.
FT   REPEAT     2242   2260       13.
FT   REPEAT     2549   2567       14.
FT   REPEAT     2716   2734       15.
FT   REPEAT     3023   3041       16.
FT   REPEAT     3190   3208       17.
FT   REPEAT     3274   3292       18.
FT   REPEAT     3439   3457       19.
FT   REPEAT     3467   3485       20.
FT   REPEAT     3632   3650       21.
FT   REPEAT     3799   3817       22.
FT   REPEAT     4106   4124       23.
FT   REPEAT     4273   4291       24.
FT   REPEAT     4522   4540       25.
FT   REPEAT     4550   4568       26.
FT   REPEAT     4715   4733       27.
FT   REPEAT     4743   4761       28.
FT   DOMAIN     5116   5154       EGF-like.
FT   DOMAIN     5168   5275       SEA. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00188}.
FT   REGION      222   4761       28 X 19 AA approximate tandem repeats of
FT                                E-E-S-X-X-X-H-X-X-P-X-X-T-X-T-X-X-X-P.
FT   MOTIF      5226   5233       Cleavage motif. {ECO:0000250}.
FT   COMPBIAS    156   5021       Ser-rich.
FT   SITE       5229   5230       Cleavage. {ECO:0000250}.
FT   CARBOHYD    154    154       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    170    170       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    176    176       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    382    382       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    738    738       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1793   1793       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3350   3350       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4433   4433       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4571   4571       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   5169   5169       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   5182   5182       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   5197   5197       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   5228   5228       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   5264   5264       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID   5144   5153       {ECO:0000250}.
FT   VAR_SEQ      23    165       Missing (in isoform 2). {ECO:0000305}.
FT                                /FTId=VSP_056721.
FT   VARIANT    4775   4775       T -> R (in dbSNP:rs11766125).
FT                                /FTId=VAR_042906.
FT   CONFLICT   3283   3286       PGST -> RNRP (in Ref. 2; AAD55679).
FT                                {ECO:0000305}.
FT   CONFLICT   3556   3556       S -> N (in Ref. 2; AAD55679).
FT                                {ECO:0000305}.
FT   CONFLICT   3686   3686       S -> P (in Ref. 2; AAD55679).
FT                                {ECO:0000305}.
FT   CONFLICT   3697   3697       S -> P (in Ref. 2; AAD55679).
FT                                {ECO:0000305}.
FT   CONFLICT   3790   3790       P -> T (in Ref. 2; AAD55679).
FT                                {ECO:0000305}.
FT   CONFLICT   3809   3809       G -> S (in Ref. 2; AAD55679).
FT                                {ECO:0000305}.
FT   CONFLICT   3966   3966       R -> G (in Ref. 2; AAD55679).
FT                                {ECO:0000305}.
FT   CONFLICT   4037   4037       K -> T (in Ref. 2; AAD55679).
FT                                {ECO:0000305}.
FT   CONFLICT   4137   4137       T -> K (in Ref. 2; AAD55679).
FT                                {ECO:0000305}.
FT   CONFLICT   4214   4214       T -> A (in Ref. 2; AAD55679).
FT                                {ECO:0000305}.
FT   CONFLICT   4238   4239       ST -> GP (in Ref. 2; AAD55679).
FT                                {ECO:0000305}.
FT   CONFLICT   4901   4901       T -> R (in Ref. 2; AAD55678).
FT                                {ECO:0000305}.
SQ   SEQUENCE   5478 AA;  558164 MW;  6157CF28FEDDA0E5 CRC64;
     MLVIWILTLA LRLCASVTTV TPEGSAVHKA ISQQGTLWTG EVLEKQTVEQ GKSTLRRQKN
     HFHRSAGELR CRNALKDEGA SAGWSVMFAG ESVVVLVHLW MTGARVKNLG LVEFASPGDD
     GDGRAEGFSL GLPLSEQARA AGAREKERQE TVINHSTFSG FSQITGSTVN TSIGGNTTSA
     STPSSSDPFT TFSDYGVSVT FITGSTATKH FLDSSTNSGH SEESTVSHSG PGATGTTLFP
     SHSATSVFVG EPKTSPITSA SMETTALPGS TTTAGLSEKS TTFYSSPRSP DRTLSPARTT
     SSGVSEKSTT SHSRPGPTHT IAFPDSTTMP GVSQESTASH SIPGSTDTTL SPGTTTPSSL
     GPESTTFHSS PGYTKTTRLP DNTTTSGLLE ASTPVHSSTG SPHTTLSPSS STTHEGEPTT
     FQSWPSSKDT SPAPSGTTSA FVKLSTTYHS SPSSTPTTHF SASSTTLGHS EESTPVHSSP
     VATATTPPPA RSATSGHVEE STAYHRSPGS TQTMHFPESS TTSGHSEESA TFHGSTTHTK
     SSTPSTTAAL AHTSYHSSLG STETTHFRDS STISGRSEES KASHSSPDAM ATTVLPAGST
     PSVLVGDSTP SPISSGSMET TALPGSTTKP GLSEKSTTFY SSPRSPDTTH LPASMTSSGV
     SEESTTSHSR PGSTHTTAFP GSTTMPGLSQ ESTASHSSPG PTDTTLSPGS TTASSLGPEY
     TTFHSRPGST ETTLLPDNTT ASGLLEASMP VHSSTRSPHT TLSPAGSTTR QGESTTFHSW
     PSSKDTRPAP PTTTSAFVEP STTSHGSPSS IPTTHISARS TTSGLVEEST TYHSSPGSTQ
     TMHFPESDTT SGRGEESTTS HSSTTHTISS APSTTSALVE EPTSYHSSPG STATTHFPDS
     STTSGRSEES TASHSSQDAT GTIVLPARST TSVLLGESTT SPISSGSMET TALPGSTTTP
     GLSERSTTFH SSPRSPATTL SPASTTSSGV SEESTTSRSR PGSTHTTAFP DSTTTPGLSR
     HSTTSHSSPG STDTTLLPAS TTTSGPSQES TTSHSSSGST DTALSPGSTT ALSFGQESTT
     FHSNPGSTHT TLFPDSTTSS GIVEASTRVH SSTGSPRTTL SPASSTSPGL QGESTAFQTH
     PASTHTTPSP PSTATAPVEE STTYHRSPGS TPTTHFPASS TTSGHSEKST IFHSSPDASG
     TTPSSAHSTT SGRGESTTSR ISPGSTEITT LPGSTTTPGL SEASTTFYSS PRSPTTTLSP
     ASMTSLGVGE ESTTSRSQPG STHSTVSPAS TTTPGLSEES TTVYSSSRGS TETTVFPHST
     TTSVHGEEPT TFHSRPASTH TTLFTEDSTT SGLTEESTAF PGSPASTQTG LPATLTTADL
     GEESTTFPSS SGSTGTKLSP ARSTTSGLVG ESTPSRLSPS STETTTLPGS PTTPSLSEKS
     TTFYTSPRSP DATLSPATTT SSGVSEESST SHSQPGSTHT TAFPDSTTTS DLSQEPTTSH
     SSQGSTEATL SPGSTTASSL GQQSTTFHSS PGDTETTLLP DDTITSGLVE ASTPTHSSTG
     SLHTTLTPAS STSAGLQEES TTFQSWPSSS DTTPSPPGTT AAPVEVSTTY HSRPSSTPTT
     HFSASSTTLG RSEESTTVHS SPGATGTALF PTRSATSVLV GEPTTSPISS GSTETTALPG
     STTTAGLSEK STTFYSSPRS PDTTLSPAST TSSGVSEEST TSHSRPGSTH TTAFPGSTTM
     PGVSQESTAS HSSPGSTDTT LSPGSTTASS LGPESTTFHS SPGSTETTLL PDNTTASGLL
     EASTPVHSST GSPHTTLSPA GSTTRQGEST TFQSWPSSKD TMPAPPTTTS AFVELSTTSH
     GSPSSTPTTH FSASSTTLGR SEESTTVHSS PVATATTPSP ARSTTSGLVE ESTAYHSSPG
     STQTMHFPES STASGRSEES RTSHSSTTHT ISSPPSTTSA LVEEPTSYHS SPGSTATTHF
     PDSSTTSGRS EESTASHSSQ DATGTIVLPA RSTTSVLLGE STTSPISSGS METTALPGST
     TTPGLSEKST TFHSSPRSPA TTLSPASTTS SGVSEESTTS HSRPGSTHTT AFPDSTTTPG
     LSRHSTTSHS SPGSTDTTLL PASTTTSGPS QESTTSHSSP GSTDTALSPG STTALSFGQE
     STTFHSSPGS THTTLFPDST TSSGIVEAST RVHSSTGSPR TTLSPASSTS PGLQGESTAF
     QTHPASTHTT PSPPSTATAP VEESTTYHRS PGSTPTTHFP ASSTTSGHSE KSTIFHSSPD
     ASGTTPSSAH STTSGRGEST TSRISPGSTE ITTLPGSTTT PGLSEASTTF YSSPRSPTTT
     LSPASMTSLG VGEESTTSRS QPGSTHSTVS PASTTTPGLS EESTTVYSSS PGSTETTVFP
     RTPTTSVRGE EPTTFHSRPA STHTTLFTED STTSGLTEES TAFPGSPAST QTGLPATLTT
     ADLGEESTTF PSSSGSTGTT LSPARSTTSG LVGESTPSRL SPSSTETTTL PGSPTTPSLS
     EKSTTFYTSP RSPDATLSPA TTTSSGVSEE SSTSHSQPGS THTTAFPDST TTPGLSRHST
     TSHSSPGSTD TTLLPASTTT SGPSQESTTS HSSPGSTDTA LSPGSTTALS FGQESTTFHS
     SPGSTHTTLF PDSTTSSGIV EASTRVHSST GSPRTTLSPA SSTSPGLQGE STTFQTHPAS
     THTTPSPPST ATAPVEESTT YHRSPGSTPT THFPASSTTS GHSEKSTIFH SSPDASGTTP
     SSAHSTTSGR GESTTSRISP GSTEITTLPG STTTPGLSEA STTFYSSPRS PTTTLSPASM
     TSLGVGEEST TSRSQPGSTH STVSPASTTT PGLSEESTTV YSSSPGSTET TVFPRSTTTS
     VRGEEPTTFH SRPASTHTTL FTEDSTTSGL TEESTAFPGS PASTQTGLPA TLTTADLGEE
     STTFPSSSGS TGTTLSPARS TTSGLVGEST PSRLSPSSTE TTTLPGSPTT PSLSEKSTTF
     YTSPRSPDAT LSPATTTSSG VSEESSTSHS QPGSTHTTAF PDSTTTSGLS QEPTASHSSQ
     GSTEATLSPG STTASSLGQQ STTFHSSPGD TETTLLPDDT ITSGLVEAST PTHSSTGSLH
     TTLTPASSTS AGLQEESTTF QSWPSSSDTT PSPPGTTAAP VEVSTTYHSR PSSTPTTHFS
     ASSTTLGRSE ESTTVHSSPG ATGTALFPTR SATSVLVGEP TTSPISSGST ETTALPGSTT
     TAGLSEKSTT FYSSPRSPDT TLSPASTTSS GVSEESTTSH SRPGSTHTTA FPGSTTMPGV
     SQESTASHSS PGSTDTTLSP GSTTASSLGP ESTTFHSGPG STETTLLPDN TTASGLLEAS
     TPVHSSTGSP HTTLSPAGST TRQGESTTFQ SWPNSKDTTP APPTTTSAFV ELSTTSHGSP
     SSTPTTHFSA SSTTLGRSEE STTVHSSPVA TATTPSPARS TTSGLVEEST TYHSSPGSTQ
     TMHFPESDTT SGRGEESTTS HSSTTHTISS APSTTSALVE EPTSYHSSPG STATTHFPDS
     STTSGRSEES TASHSSQDAT GTIVLPARST TSVLLGESTT SPISSGSMET TALPGSTTTP
     GLSEKSTTFH SSPRSPATTL SPASTTSSGV SEESTTSHSR PGSTHTTAFP DSTTTPGLSR
     HSTTSHSSPG STDTTLLPAS TTTSGSSQES TTSHSSSGST DTALSPGSTT ALSFGQESTT
     FHSSPGSTHT TLFPDSTTSS GIVEASTRVH SSTGSPRTTL SPASSTSPGL QGESTAFQTH
     PASTHTTPSP PSTATAPVEE STTYHRSPGS TPTTHFPASS TTSGHSEKST IFHSSPDASG
     TTPSSAHSTT SGRGESTTSR ISPGSTEITT LPGSTTTPGL SEASTTFYSS PRSPTTTLSP
     ASMTSLGVGE ESTTSRSQPG STHSTVSPAS TTTPGLSEES TTVYSSSPGS TETTVFPRST
     TTSVRREEPT TFHSRPASTH TTLFTEDSTT SGLTEESTAF PGSPASTQTG LPATLTTADL
     GEESTTFPSS SGSTGTKLSP ARSTTSGLVG ESTPSRLSPS STETTTLPGS PTTPSLSEKS
     TTFYTSPRSP DATLSPATTT SSGVSEESST SHSQPGSTHT TAFPDSTTTS GLSQEPTTSH
     SSQGSTEATL SPGSTTASSL GQQSTTFHSS PGDTETTLLP DDTITSGLVE ASTPTHSSTG
     SLHTTLTPAS STSTGLQEES TTFQSWPSSS DTTPSPPSTT AVPVEVSTTY HSRPSSTPTT
     HFSASSTTLG RSEESTTVHS SPGATGTALF PTRSATSVLV GEPTTSPISS GSTETTALPG
     STTTAGLSEK STTFYSSPRS PDTTLSPAST TSSGVSEEST TSHSRPGSMH TTAFPSSTTM
     PGVSQESTAS HSSPGSTDTT LSPGSTTASS LGPESTTFHS SPGSTETTLL PDNTTASGLL
     EASTPVHSST GSPHTTLSPA GSTTRQGEST TFQSWPNSKD TTPAPPTTTS AFVELSTTSH
     GSPSSTPTTH FSASSTTLGR SEESTTVHSS PVATATTPSP ARSTTSGLVE ESTTYHSSPG
     STQTMHFPES NTTSGRGEES TTSHSSTTHT ISSAPSTTSA LVEEPTSYHS SPGSTATTHF
     PDSSTTSGRS EESTASHSSQ DATGTIVLPA RSTTSVLLGE STTSPISSGS METTALPGST
     TTPGLSEKST TFHSSPSSTP TTHFSASSTT LGRSEESTTV HSSPVATATT PSPARSTTSG
     LVEESTAYHS SPGSTQTMHF PESSTASGRS EESRTSHSST THTISSPPST TSALVEEPTS
     YHSSPGSIAT THFPESSTTS GRSEESTASH SSPDTNGITP LPAHFTTSGR IAESTTFYIS
     PGSMETTLAS TATTPGLSAK STILYSSSRS PDQTLSPASM TSSSISGEPT SLYSQAESTH
     TTAFPASTTT SGLSQESTTF HSKPGSTETT LSPGSITTSS FAQEFTTPHS QPGSALSTVS
     PASTTVPGLS EESTTFYSSP GSTETTAFSH SNTMSIHSQQ STPFPDSPGF THTVLPATLT
     TTDIGQESTA FHSSSDATGT TPLPARSTAS DLVGEPTTFY ISPSPTYTTL FPASSSTSGL
     TEESTTFHTS PSFTSTIVST ESLETLAPGL CQEGQIWNGK QCVCPQGYVG YQCLSPLESF
     PVETPEKLNA TLGMTVKVTY RNFTEKMNDA SSQEYQNFST LFKNRMDVVL KGDNLPQYRG
     VNIRRLLNGS IVVKNDVILE ADYTLEYEEL FENLAEIVKA KIMNETRTTL LDPDSCRKAI
     LCYSEEDTFV DSSVTPGFDF QEQCTQKAAE GYTQFYYVDV LDGKLACVNK CTKGTKSQMN
     CNLGTCQLQR SGPRCLCPNT NTHWYWGETC EFNIAKSLVY GIVGAVMAVL LLALIILIIL
     FSLSQRKRHR EQYDVPQEWR KEGTPGIFQK TAIWEDQNLR ESRFGLENAY NNFRPTLETV
     DSGTELHIQR PEMVASTV
//
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