GenomeNet

Database: UniProt
Entry: Q9UR24
LinkDB: Q9UR24
Original site: Q9UR24 
ID   RHP26_SCHPO             Reviewed;         973 AA.
AC   Q9UR24;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   13-NOV-2019, entry version 117.
DE   RecName: Full=DNA repair protein rhp26;
DE            EC=3.6.4.-;
DE   AltName: Full=RAD26 homolog;
GN   Name=rhp26; ORFNames=SPCP25A2.02c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales;
OC   Schizosaccharomycetaceae; Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=10480889; DOI=10.1074/jbc.274.38.26822;
RA   Yasuhira S., Morimyo M., Yasui A.;
RT   "Transcription dependence and the roles of two excision repair
RT   pathways for UV damage in fission yeast Schizosaccharomyces pombe.";
RL   J. Biol. Chem. 274:26822-26827(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
RA   Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
RA   Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
RA   Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
RA   James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
RA   Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
RA   Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
RA   Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
RA   Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
RA   Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
RA   Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
RA   Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
RA   Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
RA   Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
RA   Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
RA   Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
RA   Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
RA   Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
RA   Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
RA   Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
RA   Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
RA   Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [3]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the
RT   fission yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Involved in transcription-coupled repair (TCR).
CC       {ECO:0000269|PubMed:10480889}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}.
CC       Nucleus {ECO:0000269|PubMed:16823372}.
DR   EMBL; AB022912; BAA84456.1; -; Genomic_DNA.
DR   EMBL; CU329672; CAB62827.1; -; Genomic_DNA.
DR   PIR; T50449; T50449.
DR   RefSeq; NP_588091.1; NM_001023082.2.
DR   BioGrid; 276036; 26.
DR   STRING; 4896.SPCP25A2.02c.1; -.
DR   iPTMnet; Q9UR24; -.
DR   MaxQB; Q9UR24; -.
DR   PaxDb; Q9UR24; -.
DR   PRIDE; Q9UR24; -.
DR   EnsemblFungi; SPCP25A2.02c.1; SPCP25A2.02c.1:pep; SPCP25A2.02c.
DR   GeneID; 2539473; -.
DR   KEGG; spo:SPCP25A2.02c; -.
DR   EuPathDB; FungiDB:SPCP25A2.02c; -.
DR   PomBase; SPCP25A2.02c; rhp26.
DR   HOGENOM; HOG000170952; -.
DR   InParanoid; Q9UR24; -.
DR   KO; K10841; -.
DR   OMA; RKDESCD; -.
DR   PhylomeDB; Q9UR24; -.
DR   Reactome; R-SPO-6781823; Formation of TC-NER Pre-Incision Complex.
DR   Reactome; R-SPO-6782135; Dual incision in TC-NER.
DR   Reactome; R-SPO-6782210; Gap-filling DNA repair synthesis and ligation in TC-NER.
DR   PRO; PR:Q9UR24; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0005524; F:ATP binding; ISM:PomBase.
DR   GO; GO:0003678; F:DNA helicase activity; ISM:PomBase.
DR   GO; GO:0008094; F:DNA-dependent ATPase activity; IBA:GO_Central.
DR   GO; GO:0006283; P:transcription-coupled nucleotide-excision repair; IMP:PomBase.
DR   Gene3D; 3.40.50.10810; -; 1.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038718; SNF2-like_sf.
DR   InterPro; IPR000330; SNF2_N.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF00176; SNF2_N; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding; Coiled coil; Complete proteome; Cytoplasm; Helicase;
KW   Hydrolase; Nucleotide-binding; Nucleus; Reference proteome.
FT   CHAIN         1    973       DNA repair protein rhp26.
FT                                /FTId=PRO_0000372387.
FT   DOMAIN      289    490       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      629    789       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     302    309       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   COILED       35    107       {ECO:0000255}.
FT   MOTIF       441    444       DEAH box.
SQ   SEQUENCE   973 AA;  110914 MW;  4A8C61319B7D29EB CRC64;
     MSVNEDLSHL GVFSVDQENL ERDVTNTASE YIAHESREIE KKRLQKVRKE ISSVKEKIRR
     LDERIDSRLT KISVKENFRK QLSKFRDTLQ SLQSDENDIK RRLNNEDSAN APGIGAFSTE
     ELERQELIRT GKVTPFRNLS GLQKEVDFDD ESSIREAVIK SEGTYYETAP HLSSEPSNID
     HGIIPRDEKD EYVTVDAVTE KVVTAAIDDG DDLVYRQRLN AWCANRKELR DQASASENNK
     DRGEFEGKDE WLLPHPSKKG QTFEGGFTIP GDIRPHLFRY QVTCVQWLWE LYCQEAGGII
     GDEMGLGKTI QIVSFLSSLH HSGKFQKPAL IVCPATLMKQ WVNEFHTWWA PLRVVVLHAT
     GSGQRASREK RQYESDASES EAEESKTSIK LRGASSSFHR YAKNLVESVF TRGHILITTY
     AGLRIYGDLI LPREWGYCVL DEGHKIRNPD SEISISCKQI RTVNRIILSG TPIQNNLTEL
     WNLFDFVFPG RLGTLPVFQN QFALPINIGG YANASNVQVQ TAYKCACMLR DLISPYLLRR
     MKLDVAADLP KKSEQVLFCK LTPLQRKAYQ DFLQGSDMQK ILNGKRQMLY GIDILRKICN
     HPDLVTREYL LHKEDYNYGD PEKSGKLKVI RALLTLWKKQ GHRTLLFSQT RQMLDILEIG
     LKDLPDVHYC RMDGSTSIAL RQDLVDNFNK NEYFDVFLLT TRVGGLGVNL TGADRVILFD
     PDWNPSTDAQ ARERAWRLGQ KKDVVVYRLM TAGTIEEKIY HRQIFKQFLT NKILKDPKQR
     RFFKMTDLHD LFTLGDNKTE GTETGSMFLG SERVLRKDNS SRNGNEAEDI PARDRKKHKI
     HDKGKKVNSS KVFEKMGIAS MEKYKPPQES NVTKTNSDST LGDDSVLDDI FASAGIQSTL
     KHDDIMEASQ TESILVEKEA TRVANEALRA VSSFRRPPRQ LIPPQQSTNV PGTSKPSGPI
     TSSTLLARLK QRR
//
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