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Database: UniProt
Entry: Q9V0A9
LinkDB: Q9V0A9
Original site: Q9V0A9 
ID   HELS_PYRAB              Reviewed;         715 AA.
AC   Q9V0A9; G8ZI46;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   31-JUL-2019, entry version 109.
DE   RecName: Full=ATP-dependent DNA helicase Hel308 {ECO:0000255|HAMAP-Rule:MF_00442};
DE            EC=3.6.4.12 {ECO:0000255|HAMAP-Rule:MF_00442};
GN   Name=hel308 {ECO:0000255|HAMAP-Rule:MF_00442};
GN   OrderedLocusNames=PYRAB08810; ORFNames=PAB0592;
OS   Pyrococcus abyssi (strain GE5 / Orsay).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=272844;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GE5 / Orsay;
RX   PubMed=12622808; DOI=10.1046/j.1365-2958.2003.03381.x;
RA   Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O.,
RA   Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C.,
RA   Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P.;
RT   "An integrated analysis of the genome of the hyperthermophilic
RT   archaeon Pyrococcus abyssi.";
RL   Mol. Microbiol. 47:1495-1512(2003).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=GE5 / Orsay;
RX   PubMed=22057919; DOI=10.1007/s00284-011-0035-x;
RA   Gao J., Wang J.;
RT   "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5
RT   and Pyrococcus furiosus DSM 3638.";
RL   Curr. Microbiol. 64:118-129(2012).
CC   -!- FUNCTION: DNA-dependent ATPase and 3'-5' DNA helicase that may be
CC       involved in repair of stalled replication forks.
CC       {ECO:0000255|HAMAP-Rule:MF_00442}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00442};
CC   -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_00442}.
CC   -!- SIMILARITY: Belongs to the helicase family. Hel308 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_00442}.
DR   EMBL; AJ248285; CAB49795.1; -; Genomic_DNA.
DR   EMBL; HE613800; CCE70287.1; -; Genomic_DNA.
DR   PIR; B75135; B75135.
DR   RefSeq; WP_010868004.1; NC_000868.1.
DR   SMR; Q9V0A9; -.
DR   STRING; 272844.PAB0592; -.
DR   EnsemblBacteria; CAB49795; CAB49795; PAB0592.
DR   GeneID; 1496231; -.
DR   KEGG; pab:PAB0592; -.
DR   PATRIC; fig|272844.11.peg.931; -.
DR   eggNOG; arCOG00553; Archaea.
DR   eggNOG; COG1204; LUCA.
DR   HOGENOM; HOG000227028; -.
DR   KO; K03726; -.
DR   OMA; NSNERGD; -.
DR   OrthoDB; 9752at2157; -.
DR   BioCyc; PABY272844:G1GT8-959-MONOMER; -.
DR   Proteomes; UP000000810; Chromosome.
DR   Proteomes; UP000009139; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00442; Helicase_Hel308; 1.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR022965; Helicase_Hel308.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding;
KW   Helicase; Hydrolase; Nucleotide-binding.
FT   CHAIN         1    715       ATP-dependent DNA helicase Hel308.
FT                                /FTId=PRO_0000102109.
FT   DOMAIN       33    197       Helicase ATP-binding. {ECO:0000255|HAMAP-
FT                                Rule:MF_00442}.
FT   DOMAIN      226    422       Helicase C-terminal. {ECO:0000255|HAMAP-
FT                                Rule:MF_00442}.
FT   NP_BIND      46     53       ATP. {ECO:0000255|HAMAP-Rule:MF_00442}.
FT   MOTIF         1     29       Q motif.
FT   MOTIF       145    148       DEAH box.
FT   BINDING      28     28       ATP. {ECO:0000255|HAMAP-Rule:MF_00442}.
SQ   SEQUENCE   715 AA;  82006 MW;  611401E623690EF4 CRC64;
     MKVGELNVSE KIKEILRERG IEELYPPQAE ALTSGVLEGE NLLVAIPTAS GKTLIAEIAI
     ANKLLEEGGK AVYIVPLKAL AEEKFREFKD WERLGLKVAM ATGDYDSKDE WLGKYDIIIA
     TAEKFDSLLR HGSSWIRDVK MLVIDEIHLI GSRDRGATLE FIITQMLGRA QIIGLSATIG
     NPEELAEWLN AKLIRSDWRP VKLRKGVFYQ GFVFWEDGGS ERYNSWEELV YDAVKKGKGA
     LVFVNMRRKA EKTALELAKK VKNYLDRKEL RELRELAESL EENPTNEKLA KALLSGVAFH
     HAGLGRDERV LVEDNFRKGL IKVVVATPTL SAGINTPAFR VIIRDTWRYS EFGMERIPVL
     EVQQMMGRAG RPRYDEVGEA IIVSTTEEPS LVIDHYIKGK PEKLFSQLSN ESILRSQILA
     LIATFGYSEF KEIYDFLERT FYAHQGKDPY MLEEKIRRII YFLLENEFIE VTLEDEIKPL
     PLGVRTTKLY IDPMTAKIFK DTLPRIEKNP NPLGIFHMIS LAPDLTPLSY SKRETSMLED
     EYYSLMDRLY FELDYENERK FFRAFKTALV LNAWINEVPE GEIVERFNVE PGDIYRIVET
     AEWLIYSLGE IAKVLEASQE VVDYVNTLRL RVKHGIREEL IPLMELPMVG RKRARALYNA
     GFKDLESIRN AKPSELLRIE GIGAKIVEGI FKYLGKEVKI TERPRKGTLD YFLNP
//
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