ID Q9V9C8_DROME Unreviewed; 300 AA.
AC Q9V9C8;
DT 01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2000, sequence version 2.
DT 24-JAN-2024, entry version 185.
DE SubName: Full=BG1 {ECO:0000313|EMBL:AAF44324.1};
DE SubName: Full=Bcl-2 ortholog dBorg-1 {ECO:0000313|EMBL:AAF44714.1};
DE SubName: Full=Death executioner Bcl-2 {ECO:0000313|EMBL:AAF57365.2};
DE SubName: Full=Drob-1 {ECO:0000313|EMBL:BAA89603.2};
DE SubName: Full=IP01389p {ECO:0000313|EMBL:AAY51552.1};
DE SubName: Full=Proapoptotic Bcl-2 homolog DEBCL {ECO:0000313|EMBL:AAF26289.1};
GN Name=Debcl {ECO:0000313|EMBL:AAF57365.2,
GN ECO:0000313|FlyBase:FBgn0029131};
GN Synonyms=Bcl-2 {ECO:0000313|EMBL:AAF57365.2}, bcl-2
GN {ECO:0000313|EMBL:AAF57365.2}, Bcl2 {ECO:0000313|EMBL:AAF57365.2}, BG1
GN {ECO:0000313|EMBL:AAF57365.2}, BOK {ECO:0000313|EMBL:AAF57365.2}, Bok
GN {ECO:0000313|EMBL:AAF57365.2}, Bok(Debcl)
GN {ECO:0000313|EMBL:AAF57365.2}, borg1/debcl
GN {ECO:0000313|EMBL:AAF57365.2}, buffy {ECO:0000313|EMBL:AAF57365.2},
GN CG12397 {ECO:0000313|EMBL:AAF57365.2}, DBok
GN {ECO:0000313|EMBL:AAF57365.2}, Dbok {ECO:0000313|EMBL:AAF57365.2},
GN dBOK {ECO:0000313|EMBL:AAF57365.2}, dBok
GN {ECO:0000313|EMBL:AAF57365.2}, dbok {ECO:0000313|EMBL:AAF57365.2},
GN dbok/debcl {ECO:0000313|EMBL:AAF57365.2}, dBorg-1
GN {ECO:0000313|EMBL:AAF57365.2}, dBORG-1/DROB-1/DEBCL/dBOK
GN {ECO:0000313|EMBL:AAF57365.2}, dBorg01 {ECO:0000313|EMBL:AAF57365.2},
GN dBorg1 {ECO:0000313|EMBL:AAF57365.2}, dborg1
GN {ECO:0000313|EMBL:AAF44714.1}, dBrog-1 {ECO:0000313|EMBL:AAF57365.2},
GN debc1 {ECO:0000313|EMBL:AAF57365.2}, DEBCL
GN {ECO:0000313|EMBL:AAF57365.2}, debcl {ECO:0000313|EMBL:AAF26289.1},
GN debcl/Borg1 {ECO:0000313|EMBL:AAF57365.2}, Debcl/dBorg-1/dBok/Drob-1
GN {ECO:0000313|EMBL:AAF57365.2}, Debcl/dBorg-1/dRob-1
GN {ECO:0000313|EMBL:AAF57365.2}, Debcl/Drob-1/dBorg-1/dBok
GN {ECO:0000313|EMBL:AAF57365.2}, debok {ECO:0000313|EMBL:AAF57365.2},
GN Dmel\CG33134 {ECO:0000313|EMBL:AAF57365.2}, Drob-1
GN {ECO:0000313|EMBL:AAF57365.2}, drob-1 {ECO:0000313|EMBL:BAA89603.2},
GN Drob-1/Debcl/dBORG-1 {ECO:0000313|EMBL:AAF57365.2},
GN Drob-1/Debcl/dBorg-1/DBok {ECO:0000313|EMBL:AAF57365.2},
GN Drob-1/Debcl/dBorg-1/dBok {ECO:0000313|EMBL:AAF57365.2};
GN ORFNames=CG33134 {ECO:0000313|EMBL:AAF57365.2,
GN ECO:0000313|FlyBase:FBgn0029131}, Dmel_CG33134
GN {ECO:0000313|EMBL:AAF57365.2};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:BAA89603.2};
RN [1] {ECO:0000313|EMBL:AAF44714.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=10801447; DOI=10.1016/S0960-9822(00)00474-7;
RA Brachmann C.B., Jassim O.W., Wachsmuth B.D., Cagan R.L.;
RT "The Drosophila bcl-2 family member dBorg-1 functions in the apoptotic
RT response to UV-irradiation.";
RL Curr. Biol. 10:547-550(2000).
RN [2] {ECO:0000313|EMBL:AAF26289.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=10684252; DOI=10.1083/jcb.148.4.703;
RA Colussi P.A., Quinn L.M., Huang D.C., Coombe M., Read S.H., Richardson H.,
RA Kumar S.;
RT "Debcl, a proapoptotic Bcl-2 homologue, is a component of the Drosophila
RT melanogaster cell death machinery.";
RL J. Cell Biol. 148:703-714(2000).
RN [3] {ECO:0000313|EMBL:BAA89603.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=10639136; DOI=10.1073/pnas.97.2.662;
RA Igaki T., Kanuka H., Inohara N., Sawamoto K., Nunez G., Okano H., Miura M.;
RT "Drob-1, a Drosophila member of the Bcl-2/CED-9 family that promotes cell
RT death.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:662-667(2000).
RN [4] {ECO:0000313|EMBL:AAF57365.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [5] {ECO:0000313|EMBL:AAF44324.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhou L., Steller H.;
RT "Potential Drosophila homologue of Bcl-2-related Ovarian Killer (BOK).";
RL Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:AAF57365.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537568;
RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT euchromatic genome sequence.";
RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN [7] {ECO:0000313|EMBL:AAF57365.2, ECO:0000313|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [8] {ECO:0000313|EMBL:AAF57365.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537573;
RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA Celniker S.E.;
RT "The transposable elements of the Drosophila melanogaster euchromatin: a
RT genomics perspective.";
RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN [9] {ECO:0000313|EMBL:AAF57365.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537574;
RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA Karpen G.H.;
RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN [10] {ECO:0000313|EMBL:AAF57365.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA Ashburner M., Anxolabehere D.;
RT "Combined evidence annotation of transposable elements in genome
RT sequences.";
RL PLoS Comput. Biol. 1:166-175(2005).
RN [11] {ECO:0000313|EMBL:AAY51552.1}
RP NUCLEOTIDE SEQUENCE.
RA Stapleton M., Carlson J., Chavez C., Frise E., George R., Pacleb J.,
RA Park S., Wan K., Yu C., Celniker S.;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN [12] {ECO:0000313|EMBL:AAF57365.2}
RP NUCLEOTIDE SEQUENCE.
RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S.,
RA Svirskas R., Rubin G.;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN [13] {ECO:0000313|EMBL:AAF57365.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569856; DOI=10.1126/science.1139815;
RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL Science 316:1586-1591(2007).
RN [14] {ECO:0000313|EMBL:AAF57365.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569867; DOI=10.1126/science.1139816;
RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA Dimitri P., Karpen G.H., Celniker S.E.;
RT "Sequence finishing and mapping of Drosophila melanogaster
RT heterochromatin.";
RL Science 316:1625-1628(2007).
RN [15] {ECO:0000313|EMBL:AAF57365.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26109357; DOI=.1534/g3.115.018929;
RG FlyBase Consortium;
RA Matthews B.B., Dos Santos G., Crosby M.A., Emmert D.B., St Pierre S.E.,
RA Gramates L.S., Zhou P., Schroeder A.J., Falls K., Strelets V., Russo S.M.,
RA Gelbart W.M., null;
RT "Gene Model Annotations for Drosophila melanogaster: Impact of High-
RT Throughput Data.";
RL G3 (Bethesda) 5:1721-1736(2015).
RN [16] {ECO:0000313|EMBL:AAF57365.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26109356; DOI=.1534/g3.115.018937;
RG FlyBase Consortium;
RA Crosby M.A., Gramates L.S., Dos Santos G., Matthews B.B., St Pierre S.E.,
RA Zhou P., Schroeder A.J., Falls K., Emmert D.B., Russo S.M., Gelbart W.M.,
RA null;
RT "Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.";
RL G3 (Bethesda) 5:1737-1749(2015).
RN [17] {ECO:0000313|EMBL:AAF57365.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25589440;
RA Hoskins R.A., Carlson J.W., Wan K.H., Park S., Mendez I., Galle S.E.,
RA Booth B.W., Pfeiffer B.D., George R.A., Svirskas R., Krzywinski M.,
RA Schein J., Accardo M.C., Damia E., Messina G., Mendez-Lago M.,
RA de Pablos B., Demakova O.V., Andreyeva E.N., Boldyreva L.V., Marra M.,
RA Carvalho A.B., Dimitri P., Villasante A., Zhimulev I.F., Rubin G.M.,
RA Karpen G.H., Celniker S.E.;
RT "The Release 6 reference sequence of the Drosophila melanogaster genome.";
RL Genome Res. 25:445-458(2015).
RN [18] {ECO:0000313|EMBL:AAF57365.2}
RP NUCLEOTIDE SEQUENCE.
RG FlyBase;
RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases.
RN [19] {ECO:0000313|EMBL:AAF57365.2}
RP NUCLEOTIDE SEQUENCE.
RG Berkeley Drosophila Genome Project;
RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R.,
RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C.,
RA Rubin G.;
RT "Drosophila melanogaster release 4 sequence.";
RL Submitted (MAY-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the Bcl-2 family.
CC {ECO:0000256|ARBA:ARBA00009458}.
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DR EMBL; AF178430; AAF26289.1; -; mRNA.
DR EMBL; AF222004; AAF44324.1; -; mRNA.
DR EMBL; AF244352; AAF44714.1; -; mRNA.
DR EMBL; AE013599; AAF57365.2; -; Genomic_DNA.
DR EMBL; BT022157; AAY51552.1; -; mRNA.
DR EMBL; AB032430; BAA89603.2; -; mRNA.
DR RefSeq; NP_788278.1; NM_176098.3.
DR AlphaFoldDB; Q9V9C8; -.
DR SMR; Q9V9C8; -.
DR STRING; 7227.FBpp0085443; -.
DR PaxDb; 7227-FBpp0085443; -.
DR DNASU; 53585; -.
DR EnsemblMetazoa; FBtr0086108; FBpp0085443; FBgn0029131.
DR GeneID; 53585; -.
DR KEGG; dme:Dmel_CG33134; -.
DR UCSC; CG33134-RA; d. melanogaster.
DR AGR; FB:FBgn0029131; -.
DR CTD; 53585; -.
DR FlyBase; FBgn0029131; Debcl.
DR VEuPathDB; VectorBase:FBgn0029131; -.
DR eggNOG; KOG4728; Eukaryota.
DR GeneTree; ENSGT01090000260100; -.
DR HOGENOM; CLU_922183_0_0_1; -.
DR InParanoid; Q9V9C8; -.
DR OMA; NRKVIQR; -.
DR OrthoDB; 2909137at2759; -.
DR BioGRID-ORCS; 53585; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 53585; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0029131; Expressed in capitellum (Drosophila) and 28 other cell types or tissues.
DR ExpressionAtlas; Q9V9C8; baseline and differential.
DR GO; GO:0097136; C:Bcl-2 family protein complex; IPI:FlyBase.
DR GO; GO:0005740; C:mitochondrial envelope; IDA:FlyBase.
DR GO; GO:0005741; C:mitochondrial outer membrane; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IDA:FlyBase.
DR GO; GO:0046982; F:protein heterodimerization activity; IBA:GO_Central.
DR GO; GO:0042803; F:protein homodimerization activity; IBA:GO_Central.
DR GO; GO:0006915; P:apoptotic process; IMP:FlyBase.
DR GO; GO:0060561; P:apoptotic process involved in morphogenesis; IMP:FlyBase.
DR GO; GO:0009267; P:cellular response to starvation; IMP:FlyBase.
DR GO; GO:0035234; P:ectopic germ cell programmed cell death; IMP:FlyBase.
DR GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IBA:GO_Central.
DR GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IMP:FlyBase.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IMP:FlyBase.
DR GO; GO:0070050; P:neuron cellular homeostasis; IGI:FlyBase.
DR GO; GO:0016239; P:positive regulation of macroautophagy; IMP:FlyBase.
DR GO; GO:0062100; P:positive regulation of programmed necrotic cell death; IMP:FlyBase.
DR GO; GO:0010623; P:programmed cell death involved in cell development; IMP:FlyBase.
DR GO; GO:0043067; P:regulation of programmed cell death; IGI:FlyBase.
DR GO; GO:0010212; P:response to ionizing radiation; IMP:FlyBase.
DR CDD; cd06845; Bcl-2_like; 1.
DR Gene3D; 1.10.437.10; Blc2-like; 1.
DR InterPro; IPR036834; Bcl-2-like_sf.
DR InterPro; IPR046371; Bcl-2_BH1-3.
DR InterPro; IPR026298; Bcl-2_fam.
DR InterPro; IPR002475; Bcl2-like.
DR PANTHER; PTHR11256; BCL-2 RELATED; 1.
DR PANTHER; PTHR11256:SF63; BG1; 1.
DR Pfam; PF00452; Bcl-2; 1.
DR PRINTS; PR01862; BCL2FAMILY.
DR SMART; SM00337; BCL; 1.
DR SUPFAM; SSF56854; Bcl-2 inhibitors of programmed cell death; 1.
DR PROSITE; PS50062; BCL2_FAMILY; 1.
PE 2: Evidence at transcript level;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000803};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 265..284
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 146..251
FT /note="Bcl-2 Bcl-2 homology region 1-3"
FT /evidence="ECO:0000259|SMART:SM00337"
FT REGION 44..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 300 AA; 32940 MW; FF29E0ADCF3D0942 CRC64;
MAPTTSPPPK LAKFKSSSLD HEIYTANRRG TIATASSDWK ALRGGVGGGA GGPGSVPNPS
NGRSLHAGGP MTRAASTSSL ASSTRTMTNY QEYKMDIINQ GKCLCGQYIR ARLRRAGVLN
RKVTQRLRNI LDPGSSHVVY EVFPALNSMG EELERMHPRV YTNISRQLSR APFGELEDSD
MAPMLLNLVA KDLFRSSITW GKIISIFAVC GGFAIDCVRQ GHFDYLQCLI DGLAEIIEDD
LVYWLIDNGG WLGLSRHIRP RVGEFTFLGW LTLFVTISAG AYMVSNVCRR IGGQLYSLLF
//
