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Database: UniProt
Entry: Q9VC94_DROME
LinkDB: Q9VC94_DROME
Original site: Q9VC94_DROME 
ID   Q9VC94_DROME            Unreviewed;      1430 AA.
AC   Q9VC94; Q95RD5;
DT   01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2002, sequence version 2.
DT   24-JAN-2024, entry version 183.
DE   SubName: Full=LD41803p {ECO:0000313|EMBL:AAL29009.1};
GN   Name=Rrp5 {ECO:0000313|FlyBase:FBgn0039182};
GN   Synonyms=Dmel\CG5728 {ECO:0000313|EMBL:AAF56280.2};
GN   ORFNames=CG5728 {ECO:0000313|EMBL:AAF56280.2,
GN   ECO:0000313|FlyBase:FBgn0039182}, Dmel_CG5728
GN   {ECO:0000313|EMBL:AAF56280.2};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227 {ECO:0000313|EMBL:AAF56280.2, ECO:0000313|Proteomes:UP000000803};
RN   [1] {ECO:0000313|EMBL:AAF56280.2, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA   An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA   Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA   Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA   Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA   Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA   Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA   Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2] {ECO:0000313|EMBL:AAL29009.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Berkeley {ECO:0000313|EMBL:AAL29009.1};
RA   Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M.,
RA   Chavez C., Dorsett V., Farfan D., Frise E., George R., Gonzalez M.,
RA   Guarin H., Li P., Liao G., Miranda A., Mungall C.J., Nunoo J., Pacleb J.,
RA   Paragas V., Park S., Phouanenavong S., Wan K., Yu C., Lewis S.E.,
RA   Rubin G.M., Celniker S.;
RL   Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:AAF56280.2, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537568;
RA   Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA   Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA   George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA   Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA   Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA   Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT   "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT   euchromatic genome sequence.";
RL   Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN   [4] {ECO:0000313|EMBL:AAF56280.2, ECO:0000313|Proteomes:UP000000803}
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [5] {ECO:0000313|EMBL:AAF56280.2, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537573;
RA   Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA   Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA   Celniker S.E.;
RT   "The transposable elements of the Drosophila melanogaster euchromatin: a
RT   genomics perspective.";
RL   Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN   [6] {ECO:0000313|EMBL:AAF56280.2, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537574;
RA   Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA   Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA   Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA   Karpen G.H.;
RT   "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL   Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN   [7] {ECO:0000313|EMBL:AAF56280.2, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA   Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA   Ashburner M., Anxolabehere D.;
RT   "Combined evidence annotation of transposable elements in genome
RT   sequences.";
RL   PLoS Comput. Biol. 1:166-175(2005).
RN   [8] {ECO:0000313|EMBL:AAF56280.2}
RP   NUCLEOTIDE SEQUENCE.
RA   Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S.,
RA   Svirskas R., Rubin G.;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|EMBL:AAF56280.2, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569856; DOI=10.1126/science.1139815;
RA   Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT   "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL   Science 316:1586-1591(2007).
RN   [10] {ECO:0000313|EMBL:AAF56280.2, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569867; DOI=10.1126/science.1139816;
RA   Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA   Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA   Dimitri P., Karpen G.H., Celniker S.E.;
RT   "Sequence finishing and mapping of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1625-1628(2007).
RN   [11] {ECO:0000313|EMBL:AAF56280.2}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=26109357; DOI=.1534/g3.115.018929;
RG   FlyBase Consortium;
RA   Matthews B.B., Dos Santos G., Crosby M.A., Emmert D.B., St Pierre S.E.,
RA   Gramates L.S., Zhou P., Schroeder A.J., Falls K., Strelets V., Russo S.M.,
RA   Gelbart W.M., null;
RT   "Gene Model Annotations for Drosophila melanogaster: Impact of High-
RT   Throughput Data.";
RL   G3 (Bethesda) 5:1721-1736(2015).
RN   [12] {ECO:0000313|EMBL:AAF56280.2}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=26109356; DOI=.1534/g3.115.018937;
RG   FlyBase Consortium;
RA   Crosby M.A., Gramates L.S., Dos Santos G., Matthews B.B., St Pierre S.E.,
RA   Zhou P., Schroeder A.J., Falls K., Emmert D.B., Russo S.M., Gelbart W.M.,
RA   null;
RT   "Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.";
RL   G3 (Bethesda) 5:1737-1749(2015).
RN   [13] {ECO:0000313|EMBL:AAF56280.2}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25589440;
RA   Hoskins R.A., Carlson J.W., Wan K.H., Park S., Mendez I., Galle S.E.,
RA   Booth B.W., Pfeiffer B.D., George R.A., Svirskas R., Krzywinski M.,
RA   Schein J., Accardo M.C., Damia E., Messina G., Mendez-Lago M.,
RA   de Pablos B., Demakova O.V., Andreyeva E.N., Boldyreva L.V., Marra M.,
RA   Carvalho A.B., Dimitri P., Villasante A., Zhimulev I.F., Rubin G.M.,
RA   Karpen G.H., Celniker S.E.;
RT   "The Release 6 reference sequence of the Drosophila melanogaster genome.";
RL   Genome Res. 25:445-458(2015).
RN   [14] {ECO:0000313|EMBL:AAF56280.2}
RP   NUCLEOTIDE SEQUENCE.
RG   Berkeley Drosophila Genome Project;
RA   Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R.,
RA   Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C.,
RA   Rubin G.;
RT   "Drosophila melanogaster release 4 sequence.";
RL   Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases.
RN   [15] {ECO:0000313|EMBL:AAF56280.2}
RP   NUCLEOTIDE SEQUENCE.
RG   FlyBase;
RL   Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000256|ARBA:ARBA00004604}.
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DR   EMBL; AE014297; AAF56280.2; -; Genomic_DNA.
DR   EMBL; AY061461; AAL29009.1; -; mRNA.
DR   RefSeq; NP_651245.1; NM_142988.4.
DR   AlphaFoldDB; Q9VC94; -.
DR   SMR; Q9VC94; -.
DR   IntAct; Q9VC94; 3.
DR   STRING; 7227.FBpp0084016; -.
DR   PaxDb; 7227-FBpp0084016; -.
DR   DNASU; 42899; -.
DR   EnsemblMetazoa; FBtr0084632; FBpp0084016; FBgn0039182.
DR   GeneID; 42899; -.
DR   KEGG; dme:Dmel_CG5728; -.
DR   UCSC; CG5728-RA; d. melanogaster.
DR   AGR; FB:FBgn0039182; -.
DR   FlyBase; FBgn0039182; Rrp5.
DR   VEuPathDB; VectorBase:FBgn0039182; -.
DR   eggNOG; KOG1070; Eukaryota.
DR   GeneTree; ENSGT00390000012228; -.
DR   HOGENOM; CLU_000845_0_1_1; -.
DR   InParanoid; Q9VC94; -.
DR   OMA; VILWIDY; -.
DR   OrthoDB; 167902at2759; -.
DR   Reactome; R-DME-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   BioGRID-ORCS; 42899; 1 hit in 1 CRISPR screen.
DR   GenomeRNAi; 42899; -.
DR   PRO; PR:Q9VC94; -.
DR   Proteomes; UP000000803; Chromosome 3R.
DR   Bgee; FBgn0039182; Expressed in egg chamber and 47 other cell types or tissues.
DR   GO; GO:0005730; C:nucleolus; IDA:FlyBase.
DR   GO; GO:0005634; C:nucleus; IC:FlyBase.
DR   GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; HMP:FlyBase.
DR   GO; GO:0006364; P:rRNA processing; IDA:FlyBase.
DR   CDD; cd05693; S1_Rrp5_repeat_hs1_sc1; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 2.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR   InterPro; IPR003107; HAT.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR045209; Rrp5.
DR   InterPro; IPR048059; Rrp5_S1_rpt_hs1_sc1.
DR   InterPro; IPR003029; S1_domain.
DR   InterPro; IPR008847; Suf.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR23270; PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5; 1.
DR   PANTHER; PTHR23270:SF10; PROTEIN RRP5 HOMOLOG; 1.
DR   Pfam; PF00575; S1; 1.
DR   Pfam; PF05843; Suf; 1.
DR   SMART; SM00386; HAT; 5.
DR   SMART; SM00316; S1; 6.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 3.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS50126; S1; 2.
PE   1: Evidence at protein level;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:Q9VC94};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000803};
KW   rRNA processing {ECO:0000256|ARBA:ARBA00022552}.
FT   DOMAIN          447..511
FT                   /note="S1 motif"
FT                   /evidence="ECO:0000259|PROSITE:PS50126"
FT   DOMAIN          531..592
FT                   /note="S1 motif"
FT                   /evidence="ECO:0000259|PROSITE:PS50126"
FT   REGION          1041..1145
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1043..1057
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1063..1078
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1112..1145
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1430 AA;  159806 MW;  75AA04C4A7382E88 CRC64;
     MVPNEKSFPR GGTIHSEVKT DDVSLNIVFG ASQKKVKKAP KVKENLLSYE TEEQNGQLEA
     FSAETLNMDT LQEDMLVMGV VKELTATALQ IALPGRMFAR TLVADISDAY TRVAKAAMSG
     DTSEYHDLTE LFQLGRIVYG KAIKTEKLDT GRVSLLLSLK PADVHGNLHH KSIKKGFIFS
     GAVAEALEHG YVIESGVQGL QAFVPCEKPA QKLHVGQLAF LKVKTVHHDT HQSTCTCVQV
     EQDQLRIKSQ NETNLDYILP GSIVKFKVAK HLKDGLKGSI MNESFSAYVN EHHLANALDT
     LDAYELNEDY NARVLYVMPL TKLVYLTLNL DIKTGAAVAK DQDEEEQEVE PIKVGSVVEK
     AKVLRLGSGG VVLLLNKKLK GIISYGSIRG NFKGNYDKDE VLSKYGRKTK HKVRILGYDV
     IESLYYCSDD PNVVNEKLFC LEDINAGDLV TAKIFKKDDK IKGWSVRIGK VNGILEQFYL
     APNVRYDVGQ SLKCRVLEVN AERKICYVSN RAEYLGKGIK ILTDYASAHV GNVYMGTVVR
     CEDTYVLVKF GNGIKGVLHR QNLKENSSFF EGQTTKFRIL TRNKDQITLT LPEDKFQLGE
     ICPVEITNAL DAGLEVKITF AAEDDEEDED GNPKLEEFVG LIPLRLLSDH LELLHAQMRV
     HPAGSYTDAA CIMQNIFSLR DVPYFSGQLT KDWQSVQVGD IIRSYVKHAT DQVVDLMVCV
     RNYNKPVKVH VKMLRLNAVK NAPVELVPEQ LLWVKVLSKE VETKTLTVSA KLTDVWSGDL
     SDTAKLVEGY LNEVAQIKAG LEEASAPISK YSVGEKINVV FKGIDATTND WVYTVEGNGK
     VSALLLSSLV GTAKAPEMGS KHEAVILWIE YSSDVLLISN KKLDIAHISP SGELSTNLIG
     KAGMKAKVLL KLESVAVCSL KKGTNPLVIC PIRLHPNDIE NSGSAELRQG DFCNIAFIHD
     KLHIAVPETV WRLWRGVKRT AGTEVAPVKA KKAKVEESPK QKKTTIEETS AQKKVKAKAK
     VETKTEAKAI PTKRKAEVVE KITNGQKKTQ PLTNGIVKEK PKQNGKLFFE DKTPAKNAKS
     ETPKSNGAEG KSRLPGVSSF WEDDVNQSKE GSSDEDEELN VAETQKNAAK KKRLSAKEKA
     KAEIKEEQRL REIEERNADP KARLETIDQY ERLVIAQPNN SISWLKYIAF LLSNTEIEKA
     RALARRAIST ISFRETQELR NMWSALLNME LVYSNNFDDV LKEALNCNDP LEIYISVVDI
     LKKNKRKDRL SSVLTTVLNK FKTELRVWPV AAEAYFWLGK SDQVHNLLQR ALRALPNQEH
     IPCIVSFAKL YAKHDNNDMA QTLLDDVVTS YPKRIDIWSV YVDMLIKAGL IDSARNVLER
     AVVQKLKPNK MQVIYKKYLQ LEENHGTDAT VAKVKQQAEQ WVKNYAKTVK
//
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