ID Q9VIR0_DROME Unreviewed; 1346 AA.
AC Q9VIR0;
DT 01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 2.
DT 27-MAR-2024, entry version 164.
DE SubName: Full=Sickie, isoform E {ECO:0000313|EMBL:AAF53855.2};
DE SubName: Full=Sickie, isoform G {ECO:0000313|EMBL:AGB93139.1};
GN Name=sick {ECO:0000313|EMBL:AAF53855.2,
GN ECO:0000313|FlyBase:FBgn0263873};
GN Synonyms=CG10662 {ECO:0000313|EMBL:AAF53855.2}, CG13958
GN {ECO:0000313|EMBL:AAF53855.2}, CG13959 {ECO:0000313|EMBL:AAF53855.2},
GN CG13960 {ECO:0000313|EMBL:AAF53855.2}, CG13961
GN {ECO:0000313|EMBL:AAF53855.2}, CG13964 {ECO:0000313|EMBL:AAF53855.2},
GN CG33316 {ECO:0000313|EMBL:AAF53855.2}, CG34343
GN {ECO:0000313|EMBL:AAF53855.2}, CG42589 {ECO:0000313|EMBL:AAF53855.2},
GN Dm_2L:104545 {ECO:0000313|EMBL:AAF53855.2}, Dmel\CG43720
GN {ECO:0000313|EMBL:AAF53855.2};
GN ORFNames=CG43720 {ECO:0000313|EMBL:AAF53855.2,
GN ECO:0000313|FlyBase:FBgn0263873}, Dmel_CG43720
GN {ECO:0000313|EMBL:AAF53855.2};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAF53855.2, ECO:0000313|Proteomes:UP000000803};
RN [1] {ECO:0000313|EMBL:AAF53855.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537568;
RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT euchromatic genome sequence.";
RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN [3] {ECO:0000313|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537573;
RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA Celniker S.E.;
RT "The transposable elements of the Drosophila melanogaster euchromatin: a
RT genomics perspective.";
RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN [5] {ECO:0000313|EMBL:AAF53855.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537574;
RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA Karpen G.H.;
RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN [6] {ECO:0000313|EMBL:AAF53855.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA Ashburner M., Anxolabehere D.;
RT "Combined evidence annotation of transposable elements in genome
RT sequences.";
RL PLoS Comput. Biol. 1:166-175(2005).
RN [7] {ECO:0000313|EMBL:AAF53855.2}
RP NUCLEOTIDE SEQUENCE.
RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S.,
RA Svirskas R., Rubin G.;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|EMBL:AAF53855.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569856; DOI=10.1126/science.1139815;
RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL Science 316:1586-1591(2007).
RN [9] {ECO:0000313|EMBL:AAF53855.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569867; DOI=10.1126/science.1139816;
RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA Dimitri P., Karpen G.H., Celniker S.E.;
RT "Sequence finishing and mapping of Drosophila melanogaster
RT heterochromatin.";
RL Science 316:1625-1628(2007).
RN [10] {ECO:0000313|EMBL:AAF53855.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26109357; DOI=.1534/g3.115.018929;
RG FlyBase Consortium;
RA Matthews B.B., Dos Santos G., Crosby M.A., Emmert D.B., St Pierre S.E.,
RA Gramates L.S., Zhou P., Schroeder A.J., Falls K., Strelets V., Russo S.M.,
RA Gelbart W.M., null;
RT "Gene Model Annotations for Drosophila melanogaster: Impact of High-
RT Throughput Data.";
RL G3 (Bethesda) 5:1721-1736(2015).
RN [11] {ECO:0000313|EMBL:AAF53855.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26109356; DOI=.1534/g3.115.018937;
RG FlyBase Consortium;
RA Crosby M.A., Gramates L.S., Dos Santos G., Matthews B.B., St Pierre S.E.,
RA Zhou P., Schroeder A.J., Falls K., Emmert D.B., Russo S.M., Gelbart W.M.,
RA null;
RT "Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.";
RL G3 (Bethesda) 5:1737-1749(2015).
RN [12] {ECO:0000313|EMBL:AAF53855.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25589440;
RA Hoskins R.A., Carlson J.W., Wan K.H., Park S., Mendez I., Galle S.E.,
RA Booth B.W., Pfeiffer B.D., George R.A., Svirskas R., Krzywinski M.,
RA Schein J., Accardo M.C., Damia E., Messina G., Mendez-Lago M.,
RA de Pablos B., Demakova O.V., Andreyeva E.N., Boldyreva L.V., Marra M.,
RA Carvalho A.B., Dimitri P., Villasante A., Zhimulev I.F., Rubin G.M.,
RA Karpen G.H., Celniker S.E.;
RT "The Release 6 reference sequence of the Drosophila melanogaster genome.";
RL Genome Res. 25:445-458(2015).
RN [13] {ECO:0000313|EMBL:AAF53855.2}
RP NUCLEOTIDE SEQUENCE.
RG Berkeley Drosophila Genome Project;
RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R.,
RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C.,
RA Rubin G.;
RT "Drosophila melanogaster release 4 sequence.";
RL Submitted (NOV-2022) to the EMBL/GenBank/DDBJ databases.
RN [14] {ECO:0000313|EMBL:AAF53855.2}
RP NUCLEOTIDE SEQUENCE.
RG FlyBase;
RL Submitted (NOV-2022) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the Nav/unc-53 family.
CC {ECO:0000256|ARBA:ARBA00006255}.
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DR EMBL; AE014134; AAF53855.2; -; Genomic_DNA.
DR EMBL; AE014134; AGB93139.1; -; Genomic_DNA.
DR RefSeq; NP_001260604.1; NM_001273675.1.
DR RefSeq; NP_610011.2; NM_136167.3.
DR IntAct; Q9VIR0; 6.
DR EnsemblMetazoa; FBtr0329839; FBpp0302880; FBgn0263873.
DR EnsemblMetazoa; FBtr0329844; FBpp0302885; FBgn0263873.
DR GeneID; 35277; -.
DR UCSC; CG13964-RA; d. melanogaster.
DR AGR; FB:FBgn0263873; -.
DR CTD; 35277; -.
DR FlyBase; FBgn0263873; sick.
DR VEuPathDB; VectorBase:FBgn0263873; -.
DR HOGENOM; CLU_001002_2_0_1; -.
DR OrthoDB; 4233432at2759; -.
DR BioGRID-ORCS; 35277; 0 hits in 3 CRISPR screens.
DR ChiTaRS; sick; fly.
DR GenomeRNAi; 35277; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0263873; Expressed in embryonic dorsal epidermis (Drosophila) and 43 other cell types or tissues.
DR ExpressionAtlas; Q9VIR0; baseline and differential.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0022008; P:neurogenesis; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR039041; Nav/unc-53.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12784:SF28; PROTEIN SICKIE; 1.
DR PANTHER; PTHR12784; STEERIN; 1.
DR Pfam; PF00004; AAA; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000000803}.
FT DOMAIN 1020..1176
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 34..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 96..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 522..564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 604..660
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 749..782
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 797..839
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1321..1346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 710..737
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 101..144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..229
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 646..660
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 749..774
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 800..816
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1346 AA; 147135 MW; 1A38488502982565 CRC64;
MSAVSASNRP PPSPISVPIY DGYATIRARG LTRSRSIRAE SENGAQLPPV LQKPRRQRTI
SLRSNYSLPG GQPEEIYARA KPVRTPTIGD LEPIYTNPSA FRPLSDASSS SGGGSMPCDY
QNVKKNSRFS LDSLQSSATP KTPDYNTAGE EEPIFLYTAP ESPKRRLDSG IRSSYDSSDR
GCYSPSPRMS FDMQERDCPR LRPSTLRHNS VGSTGNRRPM TLSLNETPRS PTGLPPPAPV
RRESLYAKPK IYATPMRPPT SPRLNLYELP IVTQRSNSTE LLERSCTSQS LATIDQDEML
VIPSAMPMLP NAVDRRYHTL GHMRVKSMGA GLHRSMDVPT GSMLDMASGG HWRYRAGNQS
AGNIYASAEA AVSDLNRMAP EYMDPLDFKI GCQTTLRSKP LIPWYELAIR RDFKRQSCPP
ISGSGVGGGV CGSLTLATSP QEDHEQAHVV TAFEQSLSNM TNRLHQLTAT AERKDGELTD
MRQTIELLRK QSIQAGLTTA HMQSMGVQTQ GQGQVQGQAL GQALGQPGSD QKPPNSGSQR
AINANNGSMP LGMQRQHSTD SMCSLNSISS GCSAAQDKNK ANKKKGWLRS SFTKAFSRNA
KISKTSRHVG HHHHHNHSQQ ELASGKLPLH NGHGEPLGLA SLATQPAPPL PNSKQSSPAK
TVTLIDNAKP IDAIDQEDQH VVEDLKKQLR EKDLVLTDIR LEALSSASQL ESLKEMMNKM
RAEMMSLKHN NERLQKLVTT RSLAGSEASL GQAISPNGSV AGSSEVSRRY SLADSNSRPP
MELPARLSEE LELEEDCLPP APAPEQPPPP APNGVSVAPL SPSTHVDLTP PPPALEAAPM
ASPVHMASAT EELADVCDGK KIAIACYLGQ PEAFAKYCEE LQELDGFYAN GHEADSQSQS
ERKSNYTSAS CNEFVIACTY ISGKTTWQNL DYVVRKTFKD YVARIDPGTN LGLNTDSITS
YHLGEAKRGP EMGFPELLPC GYIVGSVRTL YICLQGVGSL AFDSLIPRSI VHRYISLLTE
HRRLILCGPS GTGKSYLARR LAEFLVARSA RGNPSEAIAT FNVDHKSSKD LRQYLGHIAE
QAAIANGVSE LPSVIILDNL HHASALGDVF SCLLSAGPAN KLPCIIGTMS QATCNTTNLQ
LHHNFRWVLT ANHMEPVKGF LGRFLRRRLF QLELQTQHPQ PELAAVLAWL PSVWQHINRF
LEVHSSSDVT IGPRLFLACP MDLKDSQVWF TDIWNYHLSP YLVEAVREGV QLYGRRGGAW
NDPSAFIRNS YPWPYGPDSV PPLRQINAED VGLEGVALTN GDQQDPLLNM LMRLQEAANY
SEAQDQESDC ASLDSNVTPE SSAGAE
//
