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Database: UniProt
Entry: Q9VQW1_DROME
LinkDB: Q9VQW1_DROME
Original site: Q9VQW1_DROME 
ID   Q9VQW1_DROME            Unreviewed;      1198 AA.
AC   Q9VQW1;
DT   01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 4.
DT   24-JAN-2024, entry version 180.
DE   SubName: Full=Friend of echinoid, isoform G {ECO:0000313|EMBL:AAF51051.4};
GN   Name=fred {ECO:0000313|EMBL:AAF51051.4,
GN   ECO:0000313|FlyBase:FBgn0051774};
GN   Synonyms=CG12675 {ECO:0000313|EMBL:AAF51051.4}, CG3390
GN   {ECO:0000313|EMBL:AAF51051.4}, CG3393 {ECO:0000313|EMBL:AAF51051.4},
GN   CT11413 {ECO:0000313|EMBL:AAF51051.4}, Dmel\CG31774
GN   {ECO:0000313|EMBL:AAF51051.4}, Fred {ECO:0000313|EMBL:AAF51051.4};
GN   ORFNames=CG31774 {ECO:0000313|EMBL:AAF51051.4,
GN   ECO:0000313|FlyBase:FBgn0051774}, Dmel_CG31774
GN   {ECO:0000313|EMBL:AAF51051.4};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227 {ECO:0000313|EMBL:AAF51051.4, ECO:0000313|Proteomes:UP000000803};
RN   [1] {ECO:0000313|EMBL:AAF51051.4, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA   An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA   Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA   Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA   Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA   Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA   Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA   Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2] {ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537568;
RA   Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA   Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA   George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA   Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA   Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA   Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT   "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT   euchromatic genome sequence.";
RL   Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN   [3] {ECO:0000313|Proteomes:UP000000803}
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4] {ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537573;
RA   Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA   Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA   Celniker S.E.;
RT   "The transposable elements of the Drosophila melanogaster euchromatin: a
RT   genomics perspective.";
RL   Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN   [5] {ECO:0000313|EMBL:AAF51051.4, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537574;
RA   Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA   Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA   Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA   Karpen G.H.;
RT   "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL   Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN   [6] {ECO:0000313|EMBL:AAF51051.4, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA   Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA   Ashburner M., Anxolabehere D.;
RT   "Combined evidence annotation of transposable elements in genome
RT   sequences.";
RL   PLoS Comput. Biol. 1:166-175(2005).
RN   [7] {ECO:0000313|EMBL:AAF51051.4, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569856; DOI=10.1126/science.1139815;
RA   Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT   "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL   Science 316:1586-1591(2007).
RN   [8] {ECO:0000313|EMBL:AAF51051.4, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569867; DOI=10.1126/science.1139816;
RA   Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA   Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA   Dimitri P., Karpen G.H., Celniker S.E.;
RT   "Sequence finishing and mapping of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1625-1628(2007).
CC   -!- INTERACTION:
CC       Q9VQW1; Q9VQW7: ed; NbExp=2; IntAct=EBI-6895702, EBI-85823;
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DR   EMBL; AE014134; AAF51051.4; -; Genomic_DNA.
DR   RefSeq; NP_722954.3; NM_164569.4.
DR   AlphaFoldDB; Q9VQW1; -.
DR   SMR; Q9VQW1; -.
DR   IntAct; Q9VQW1; 1.
DR   EnsemblMetazoa; FBtr0308126; FBpp0300448; FBgn0051774.
DR   GeneID; 33613; -.
DR   UCSC; CG31774-RA; d. melanogaster.
DR   AGR; FB:FBgn0051774; -.
DR   CTD; 33613; -.
DR   FlyBase; FBgn0051774; fred.
DR   VEuPathDB; VectorBase:FBgn0051774; -.
DR   GeneTree; ENSGT00940000170911; -.
DR   HOGENOM; CLU_004622_0_0_1; -.
DR   OMA; PFNSKRI; -.
DR   OrthoDB; 3640071at2759; -.
DR   BioGRID-ORCS; 33613; 0 hits in 1 CRISPR screen.
DR   ChiTaRS; fred; fly.
DR   GenomeRNAi; 33613; -.
DR   Proteomes; UP000000803; Chromosome 2L.
DR   Bgee; FBgn0051774; Expressed in brain and 12 other cell types or tissues.
DR   ExpressionAtlas; Q9VQW1; baseline and differential.
DR   Genevisible; Q9VQW1; DM.
DR   GO; GO:0005911; C:cell-cell junction; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0050839; F:cell adhesion molecule binding; IBA:GO_Central.
DR   GO; GO:0035018; P:adult chitin-based cuticle pattern formation; IMP:FlyBase.
DR   GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR   GO; GO:0001745; P:compound eye morphogenesis; IMP:FlyBase.
DR   GO; GO:0007423; P:sensory organ development; IMP:FlyBase.
DR   CDD; cd00063; FN3; 1.
DR   CDD; cd00096; Ig; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 8.
DR   InterPro; IPR013162; CD80_C2-set.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   PANTHER; PTHR11640:SF134; ECHINOID, ISOFORM A-RELATED; 1.
DR   PANTHER; PTHR11640; NEPHRIN; 1.
DR   Pfam; PF08205; C2-set_2; 1.
DR   Pfam; PF13895; Ig_2; 1.
DR   Pfam; PF13927; Ig_3; 4.
DR   SMART; SM00060; FN3; 1.
DR   SMART; SM00409; IG; 7.
DR   SMART; SM00408; IGc2; 6.
DR   SUPFAM; SSF49265; Fibronectin type III; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 7.
DR   PROSITE; PS50853; FN3; 1.
DR   PROSITE; PS50835; IG_LIKE; 7.
PE   1: Evidence at protein level;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000803};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..1198
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004338408"
FT   TRANSMEM        989..1011
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          29..124
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          131..225
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          232..310
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          316..396
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          411..487
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          505..615
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          618..715
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          722..841
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   REGION          1021..1099
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1178..1198
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1198 AA;  131236 MW;  7B17B081039AED60 CRC64;
     MSTIKLLIIG QLWLSIGLIS GDDSLDTREG VDLVLKCRFT EHYDSTDFTF YWARWTCCPT
     LFENVAIGDV QLNSNYRLDF RPSRGIYDLQ IKNTSYNRDN GRFECRIKAK GTGADVHQEF
     YNLTVLTAPH PPMVTPGNLA VATEEKPLEL TCSSIGGSPD PMITWYREGS TVPLQSYALK
     GGSKNHYTNA TLQIVPRRAD DGAKYKCVVW NRAMPEGHML ETSVTLNVNY YPRVEVGPQN
     PLKVERDHVA KLDCRVDAKP MVSNVRWSRN GQYVSATPTH TIYRVNRHHA GKYTCSADNG
     LGKTGEKDIV LDVLYPPIVF IESKTHEAEE GETVLIRCNV TANPSPINVE WLKEGAPDFR
     YTGELLTLGS VRAEHAGNYI CRSVNIMQPF SSKRVEGVGN STVALLVRHR PGQAYITPNK
     PVVHVGNGVT LTCSANPPGW PVPQYRWFRD MDGDIGNTQK ILAQGPQYSI PKAHLGSEGK
     YHCHAVNELG IGKIATIILE VHQPPQFLAK LQQHMTRRVG DVDYAVTCSA KGKPTPQIRW
     IKDGTEILPT RKMFDIRTTP TDAGGGVVAV QSILRFRGKA RPNGNQLLPN DRGLYTCLYE
     NDVNSANSSM HLRIEHEPIV IHQYNKVAYD LRESAEVVCR VQAYPKPEFQ WQYGNNPSPL
     TMSSDGHYEI STRMENNDVY TSILRIAHLQ HSDYGEYICR AVNPLDSIRA PIRLQPKGSP
     EKPTNLKILE VGHNYAVLNW TPGFNGGFMS TKYLVSYRRV ATPREQTLSD CSGNGYIPSY
     QISSSSSNSN HEWIEFNCFK ENPCKLAPLD QHQSYMFKVY ALNSKGTSGY SNEILATTKV
     SKIPPPLHVS YDPNSHVLGI NVAATCLSLI AVVESLVTRD ATVPMWEIVE TLTLLPSGSE
     TTFKEAIINH VSRPAHYTTA TTSGRSLGVG GGSHLGEDRT MALAETAGPG PVVRVKLCLR
     SNHEHCGAYA NAEIGKSYMP HKSSMTTSAL VAIIIASLSF VVFLGLLYAF CHCRRKHAAK
     KESSSVGGGV GGGNANATAN PGSTGAKEYD LDLDASRRPS LSQDPQQSQQ QPPPPPPYYP
     TGTLDSKDIG NGNGGMELTL TALHDPDEQL NMQQQQHHSN HGQYQQPKAI LGIYGGVAGS
     GGNNSGGQHP HSNGYGYHVT SAIGVDSDSY QVLPSVANSA AGSHGHGSGH GHGLGAGE
//
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