ID Q9VQW1_DROME Unreviewed; 1198 AA.
AC Q9VQW1;
DT 01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 4.
DT 24-JAN-2024, entry version 180.
DE SubName: Full=Friend of echinoid, isoform G {ECO:0000313|EMBL:AAF51051.4};
GN Name=fred {ECO:0000313|EMBL:AAF51051.4,
GN ECO:0000313|FlyBase:FBgn0051774};
GN Synonyms=CG12675 {ECO:0000313|EMBL:AAF51051.4}, CG3390
GN {ECO:0000313|EMBL:AAF51051.4}, CG3393 {ECO:0000313|EMBL:AAF51051.4},
GN CT11413 {ECO:0000313|EMBL:AAF51051.4}, Dmel\CG31774
GN {ECO:0000313|EMBL:AAF51051.4}, Fred {ECO:0000313|EMBL:AAF51051.4};
GN ORFNames=CG31774 {ECO:0000313|EMBL:AAF51051.4,
GN ECO:0000313|FlyBase:FBgn0051774}, Dmel_CG31774
GN {ECO:0000313|EMBL:AAF51051.4};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAF51051.4, ECO:0000313|Proteomes:UP000000803};
RN [1] {ECO:0000313|EMBL:AAF51051.4, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537568;
RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT euchromatic genome sequence.";
RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN [3] {ECO:0000313|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537573;
RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA Celniker S.E.;
RT "The transposable elements of the Drosophila melanogaster euchromatin: a
RT genomics perspective.";
RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN [5] {ECO:0000313|EMBL:AAF51051.4, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537574;
RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA Karpen G.H.;
RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN [6] {ECO:0000313|EMBL:AAF51051.4, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA Ashburner M., Anxolabehere D.;
RT "Combined evidence annotation of transposable elements in genome
RT sequences.";
RL PLoS Comput. Biol. 1:166-175(2005).
RN [7] {ECO:0000313|EMBL:AAF51051.4, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569856; DOI=10.1126/science.1139815;
RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL Science 316:1586-1591(2007).
RN [8] {ECO:0000313|EMBL:AAF51051.4, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569867; DOI=10.1126/science.1139816;
RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA Dimitri P., Karpen G.H., Celniker S.E.;
RT "Sequence finishing and mapping of Drosophila melanogaster
RT heterochromatin.";
RL Science 316:1625-1628(2007).
CC -!- INTERACTION:
CC Q9VQW1; Q9VQW7: ed; NbExp=2; IntAct=EBI-6895702, EBI-85823;
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DR EMBL; AE014134; AAF51051.4; -; Genomic_DNA.
DR RefSeq; NP_722954.3; NM_164569.4.
DR AlphaFoldDB; Q9VQW1; -.
DR SMR; Q9VQW1; -.
DR IntAct; Q9VQW1; 1.
DR EnsemblMetazoa; FBtr0308126; FBpp0300448; FBgn0051774.
DR GeneID; 33613; -.
DR UCSC; CG31774-RA; d. melanogaster.
DR AGR; FB:FBgn0051774; -.
DR CTD; 33613; -.
DR FlyBase; FBgn0051774; fred.
DR VEuPathDB; VectorBase:FBgn0051774; -.
DR GeneTree; ENSGT00940000170911; -.
DR HOGENOM; CLU_004622_0_0_1; -.
DR OMA; PFNSKRI; -.
DR OrthoDB; 3640071at2759; -.
DR BioGRID-ORCS; 33613; 0 hits in 1 CRISPR screen.
DR ChiTaRS; fred; fly.
DR GenomeRNAi; 33613; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0051774; Expressed in brain and 12 other cell types or tissues.
DR ExpressionAtlas; Q9VQW1; baseline and differential.
DR Genevisible; Q9VQW1; DM.
DR GO; GO:0005911; C:cell-cell junction; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0050839; F:cell adhesion molecule binding; IBA:GO_Central.
DR GO; GO:0035018; P:adult chitin-based cuticle pattern formation; IMP:FlyBase.
DR GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR GO; GO:0001745; P:compound eye morphogenesis; IMP:FlyBase.
DR GO; GO:0007423; P:sensory organ development; IMP:FlyBase.
DR CDD; cd00063; FN3; 1.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 8.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR11640:SF134; ECHINOID, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR11640; NEPHRIN; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF13927; Ig_3; 4.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00409; IG; 7.
DR SMART; SM00408; IGc2; 6.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 7.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50835; IG_LIKE; 7.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000803};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1198
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004338408"
FT TRANSMEM 989..1011
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 29..124
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 131..225
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 232..310
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 316..396
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 411..487
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 505..615
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 618..715
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 722..841
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1021..1099
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1178..1198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1198 AA; 131236 MW; 7B17B081039AED60 CRC64;
MSTIKLLIIG QLWLSIGLIS GDDSLDTREG VDLVLKCRFT EHYDSTDFTF YWARWTCCPT
LFENVAIGDV QLNSNYRLDF RPSRGIYDLQ IKNTSYNRDN GRFECRIKAK GTGADVHQEF
YNLTVLTAPH PPMVTPGNLA VATEEKPLEL TCSSIGGSPD PMITWYREGS TVPLQSYALK
GGSKNHYTNA TLQIVPRRAD DGAKYKCVVW NRAMPEGHML ETSVTLNVNY YPRVEVGPQN
PLKVERDHVA KLDCRVDAKP MVSNVRWSRN GQYVSATPTH TIYRVNRHHA GKYTCSADNG
LGKTGEKDIV LDVLYPPIVF IESKTHEAEE GETVLIRCNV TANPSPINVE WLKEGAPDFR
YTGELLTLGS VRAEHAGNYI CRSVNIMQPF SSKRVEGVGN STVALLVRHR PGQAYITPNK
PVVHVGNGVT LTCSANPPGW PVPQYRWFRD MDGDIGNTQK ILAQGPQYSI PKAHLGSEGK
YHCHAVNELG IGKIATIILE VHQPPQFLAK LQQHMTRRVG DVDYAVTCSA KGKPTPQIRW
IKDGTEILPT RKMFDIRTTP TDAGGGVVAV QSILRFRGKA RPNGNQLLPN DRGLYTCLYE
NDVNSANSSM HLRIEHEPIV IHQYNKVAYD LRESAEVVCR VQAYPKPEFQ WQYGNNPSPL
TMSSDGHYEI STRMENNDVY TSILRIAHLQ HSDYGEYICR AVNPLDSIRA PIRLQPKGSP
EKPTNLKILE VGHNYAVLNW TPGFNGGFMS TKYLVSYRRV ATPREQTLSD CSGNGYIPSY
QISSSSSNSN HEWIEFNCFK ENPCKLAPLD QHQSYMFKVY ALNSKGTSGY SNEILATTKV
SKIPPPLHVS YDPNSHVLGI NVAATCLSLI AVVESLVTRD ATVPMWEIVE TLTLLPSGSE
TTFKEAIINH VSRPAHYTTA TTSGRSLGVG GGSHLGEDRT MALAETAGPG PVVRVKLCLR
SNHEHCGAYA NAEIGKSYMP HKSSMTTSAL VAIIIASLSF VVFLGLLYAF CHCRRKHAAK
KESSSVGGGV GGGNANATAN PGSTGAKEYD LDLDASRRPS LSQDPQQSQQ QPPPPPPYYP
TGTLDSKDIG NGNGGMELTL TALHDPDEQL NMQQQQHHSN HGQYQQPKAI LGIYGGVAGS
GGNNSGGQHP HSNGYGYHVT SAIGVDSDSY QVLPSVANSA AGSHGHGSGH GHGLGAGE
//