ID Q9VZG5_DROME Unreviewed; 2712 AA.
AC Q9VZG5;
DT 01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 2.
DT 27-MAR-2024, entry version 154.
DE SubName: Full=Uncharacterized protein, isoform D {ECO:0000313|EMBL:AAF47858.2};
GN Name=CG1295 {ECO:0000313|EMBL:AAF47858.2};
GN Synonyms=CG1308 {ECO:0000313|EMBL:AAF47858.2}, CG1332
GN {ECO:0000313|EMBL:AAF47858.2}, Dmel\CG43367
GN {ECO:0000313|EMBL:AAF47858.2};
GN ORFNames=CG43367 {ECO:0000313|EMBL:AAF47858.2,
GN ECO:0000313|FlyBase:FBgn0263110}, Dmel_CG43367
GN {ECO:0000313|EMBL:AAF47858.2};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAF47858.2, ECO:0000313|Proteomes:UP000000803};
RN [1] {ECO:0000313|EMBL:AAF47858.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537568;
RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT euchromatic genome sequence.";
RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN [3] {ECO:0000313|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537573;
RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA Celniker S.E.;
RT "The transposable elements of the Drosophila melanogaster euchromatin: a
RT genomics perspective.";
RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN [5] {ECO:0000313|EMBL:AAF47858.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537574;
RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA Karpen G.H.;
RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN [6] {ECO:0000313|EMBL:AAF47858.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA Ashburner M., Anxolabehere D.;
RT "Combined evidence annotation of transposable elements in genome
RT sequences.";
RL PLoS Comput. Biol. 1:166-175(2005).
RN [7] {ECO:0000313|EMBL:AAF47858.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569856; DOI=10.1126/science.1139815;
RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL Science 316:1586-1591(2007).
RN [8] {ECO:0000313|EMBL:AAF47858.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569867; DOI=10.1126/science.1139816;
RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA Dimitri P., Karpen G.H., Celniker S.E.;
RT "Sequence finishing and mapping of Drosophila melanogaster
RT heterochromatin.";
RL Science 316:1625-1628(2007).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE014296; AAF47858.2; -; Genomic_DNA.
DR RefSeq; NP_647869.3; NM_139612.3.
DR SMR; Q9VZG5; -.
DR IntAct; Q9VZG5; 2.
DR EnsemblMetazoa; FBtr0307310; FBpp0298311; FBgn0263110.
DR GeneID; 38505; -.
DR UCSC; CG1308-RA; d. melanogaster.
DR AGR; FB:FBgn0263110; -.
DR FlyBase; FBgn0263110; CG43367.
DR VEuPathDB; VectorBase:FBgn0263110; -.
DR OrthoDB; 47483at2759; -.
DR PhylomeDB; Q9VZG5; -.
DR BioGRID-ORCS; 38505; 0 hits in 3 CRISPR screens.
DR ChiTaRS; CG43367; fly.
DR GenomeRNAi; 38505; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0263110; Expressed in adult Malpighian tubule (Drosophila) and 30 other cell types or tissues.
DR ExpressionAtlas; Q9VZG5; baseline and differential.
DR Genevisible; Q9VZG5; DM.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR GO; GO:0008104; P:protein localization; IBA:GO_Central.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR046851; NBCH_WD40.
DR InterPro; IPR031570; NBEA/BDCP_DUF4704.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743:SF112; BEACH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF15787; DUF4704; 1.
DR Pfam; PF16057; DUF4800; 1.
DR Pfam; PF20426; NBCH_WD40; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000803};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 1907..2004
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2017..2309
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 2459..2496
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 2536..2577
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 712..731
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1399..1442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 716..731
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2712 AA; 305226 MW; 0F27A249AE61771B CRC64;
MDNKKDIYNL WVQYTTKNDE THFRQFVARF VAIWRSQLQL DFQAENCPMW HEVQPDSGPH
LGRLPDELLP AIGKFIIVAR DVCETEGKLE EQAIEEVAIL VDCLVIVCRH FDNILSIIKY
EYKPNLIAIL SRVFKQQMEL PQSVPAISHL FSSFSAFLEV MYDPYLTWRS FVRGQSADYS
RLSYKPHSVH VEIVPFIYDC FQEEKLIRYA EIGESLLNIL GAVICGSQRN GMKAICPATV
SITMSILRQW ESANNLRRVA LQCYALMVIV LQKSSPEERQ IDLVTLVQLY CDALQELLAT
KHFDSGDANF DITSDADQDV AIDMAALSST VAAVKFFVTG DAGVSEAVSD SNLLELLTNL
PKLIKPWHIS HSSSLCSTME ALAILARHSP QSASQLRQGE RIERLFTSLQ EYGSPTVELL
DTCFMLGYDE SEHFLLLPEV MLRLLNWVPT LQEREQLHVT SLVLKGCTDN YRTKTVACGS
HIIKAVCGCL LTAESLAENC VQNLIKLIEE LSKLSIVPAE LKCIFSLLRQ GTKFPQFKQL
QQTLVVIALQ SLRGSNSCAE FFSIEQPTDG ILVPDIRNWT ISGSYGFIFH ILVRFNQLKE
QSNSRRMLLT LQTASGSGFE VFVQPNGNVV VAALTRREYL TSSTATKTLM DGQWHYLTVA
ITPPKRPFSY SQINIYVDFV QKLSATLKVQ AVNEPFTVCS IGAVVAPPQP GEVAKTGNMP
RSSSQESGSS GYKGMLPSLL ERTLSANVSN YFTLPMRTQT AFDPNVKNFP IGMQDTVFGE
QTCLNGHLGG VLLADPTTSL KTIFDAGANF SSIFSQDNDL LELNSRFVFC YAPGAIWHGT
CQDLIPGGKY PGRINAQHCK IVKIQETINS IGGISAILPM LHRLITLDQT TDISIGSVSE
ESLSCAPTPS AEEFTDWEML SSNSYTEWKM LQHPLASFLC LLRYLTHEHE TNQEQLLSSE
CLAIVGTMLQ RCPPSLFDVN ALMATHLLME SLQGHKAEAG GQLLDALYAH IVFDFAIWSR
LQFQITLGHA QYLSAMIKND RKFFRKRYGV QFVLDVVRQY YSTPDSISDD DAKTIRATLF
GIIKFYLQKD VNIKEVNSMI TFLASVRQDV VLVEFLEMMT FYVRGKNCKD QMVLLLHEPQ
SANLLYNFFV DKSYSNEIQE AAIRFISGLL ATSRVHQKYK QVLRLYDQTT EQSMFPGFFS
FITPLSLSST ILFHLVDEML GLQPDYAGLI FLVYHVSSCD LPVKLEIAKR LLQTTFVKQQ
STVAMAKQTG WQESIARLLI RKPITSSPPD EEKRRSFGIN LDVLLEDNSN FLAQADLITF
SEQEIGLAQL QQQQQEELSD SGLILNEIQA SVTEAATVIE SEIKELAESV SGAVVENANS
LFSVIRQTTH DLQDTFESLT QGSSTDTADG SQTPSIQREE SLSSDTSSQS PHGPPKKSDS
LESTSAFDFV ADGDVDTEEQ LVYLVSNTLF NIFWRGIPND HPQCWQERGQ VLGCINLLAL
NNELITSHLS LRLRILEMAV QASLFDLSEH GSQTLVNQEN ASHILRMVYE LVVLGSNEDE
SKKCSTKLLD GVLALLDALM IFQQGSSDDW SDMIRLCLGL LLKCSHHPNP GIVAMATAKL
HAILQSRSTE DPAELSYLLY SINRALDNAI EVGNPEEYSF LMPVMKALLE KCRVAFNLDS
TLPDLPSTSS GPVFFNDFQM YSTSKKWRNF IERMVKPLYD RYQRDIELHL WEPINRFWAE
CYEACKAASK QRATNQAENR RLFQQKIYMP WKVRQVEEMQ RLQAAALQHK TIDSHIRKRW
KTAKRFLYGP RGPWYTGEVD EEFWKLSQHE NVARMRLKLE PQLYPNKHEN AANLRDNATS
AYDTKEISEF DSTIKNAVVR DFLADDESSQ LEEELRQLID TQAQQDVALE KLVMSQDCEL
ITLMTKVKGR IEVNQSVFTF VDLSPPTEDG SKYDFRFSTN KIREVHLRKY NLRRSALEIF
LVDQTSYFLN FTTKTRNKVF TKIVGLPLPN ILYGSGRSPA ELLRASGLTQ RWINREISNF
EYLMYLNTIA GRSYNDLSQY PVFPWILADY TSDVLDLTDP KSFRDLSKPI GCINPKNEAE
VRGKYDSFED PSGAIPKFHY GTHYSNSAGV LHYLLRVEPF TSLHIDLQSG RFDVADRQFH
SIPQTWKLLM DNPNDVKELI PEFFYFPEFL KNMNKFDLGH LQITKEKVDD VILPAWATTP
EEFIAIHRRA LESEYVSQHL HHWIDLIFGY KQKGPKAAEA LNVFYYCSYE GAVDLDKITN
PVEREAVEGM INNFGQVPSQ LLREPHPRRL TQDETALKLV RAELRRPDLT QFLDKVVQYY
CELSTPKDPI VYLSPPRSPP RSFLQLSPDV LVSISKSTIL GCNSWLSFDK DQGFLLEIDA
TTANLKNRKR IFGPFHSSQQ PHSQLFAVST DGKLLYAGGI WDNSLRVYNL NKGKAVASVT
RHLDIITCIA LDNCGSYLVT GSRDCTCIVW SIQTNQQGGG STNNIPVHAL TGQSHLQAIT
QLNTQNSYSP KPLTVLYGHD DAISSVAIYT ELDLVVSGSL DGTVNVYTLQ EGQFVRTLKP
IGCTESCVQI SFVTLSYHGH IAFSALDDTS HSVHVYSING CSLGSKYVSG RVTGLASASD
YLVVADDAGD ITMSRLHGLK PVFDIPLHVP IQTVVVTPGN THILAPLRDG RLAVIAVQLP
SGGNKKHSVL NV
//
