ID Q9W0B0_DROME Unreviewed; 1107 AA.
AC Q9W0B0; Q9W0B1;
DT 01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 2.
DT 27-MAR-2024, entry version 148.
DE SubName: Full=Serine-arginine repetitive matrix 2/3/4, isoform C {ECO:0000313|EMBL:AAF47542.2};
GN Name=Srrm234 {ECO:0000313|EMBL:AAF47542.2,
GN ECO:0000313|FlyBase:FBgn0035253};
GN Synonyms=anon-EST:fe1A7 {ECO:0000313|EMBL:AAF47542.2}, BcDNA:GH04236
GN {ECO:0000313|EMBL:AAF47542.2}, Dmel\CG7971
GN {ECO:0000313|EMBL:AAF47542.2}, SRm300 {ECO:0000313|EMBL:AAF47542.2};
GN ORFNames=CG7971 {ECO:0000313|EMBL:AAF47542.2,
GN ECO:0000313|FlyBase:FBgn0035253}, Dmel_CG7971
GN {ECO:0000313|EMBL:AAF47542.2};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAF47542.2, ECO:0000313|Proteomes:UP000000803};
RN [1] {ECO:0000313|EMBL:AAF47542.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537568;
RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT euchromatic genome sequence.";
RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN [3] {ECO:0000313|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537573;
RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA Celniker S.E.;
RT "The transposable elements of the Drosophila melanogaster euchromatin: a
RT genomics perspective.";
RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN [5] {ECO:0000313|EMBL:AAF47542.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537574;
RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA Karpen G.H.;
RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN [6] {ECO:0000313|EMBL:AAF47542.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA Ashburner M., Anxolabehere D.;
RT "Combined evidence annotation of transposable elements in genome
RT sequences.";
RL PLoS Comput. Biol. 1:166-175(2005).
RN [7] {ECO:0000313|EMBL:AAF47542.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569856; DOI=10.1126/science.1139815;
RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL Science 316:1586-1591(2007).
RN [8] {ECO:0000313|EMBL:AAF47542.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569867; DOI=10.1126/science.1139816;
RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA Dimitri P., Karpen G.H., Celniker S.E.;
RT "Sequence finishing and mapping of Drosophila melanogaster
RT heterochromatin.";
RL Science 316:1625-1628(2007).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CWC21 family.
CC {ECO:0000256|ARBA:ARBA00005954}.
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DR EMBL; AE014296; AAF47542.2; -; Genomic_DNA.
DR RefSeq; NP_728652.1; NM_167909.4.
DR AlphaFoldDB; Q9W0B0; -.
DR SMR; Q9W0B0; -.
DR DNASU; 38206; -.
DR EnsemblMetazoa; FBtr0072807; FBpp0072689; FBgn0035253.
DR GeneID; 38206; -.
DR UCSC; CG7971-RC; d. melanogaster.
DR AGR; FB:FBgn0035253; -.
DR CTD; 38206; -.
DR FlyBase; FBgn0035253; Srrm234.
DR VEuPathDB; VectorBase:FBgn0035253; -.
DR GeneTree; ENSGT00940000171190; -.
DR OrthoDB; 25337at2759; -.
DR PhylomeDB; Q9W0B0; -.
DR BioGRID-ORCS; 38206; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 38206; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0035253; Expressed in cleaving embryo and 28 other cell types or tissues.
DR ExpressionAtlas; Q9W0B0; baseline and differential.
DR Genevisible; Q9W0B0; DM.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; HDA:FlyBase.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0071011; C:precatalytic spliceosome; HDA:FlyBase.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IC:FlyBase.
DR CDD; cd21373; cwf21_SRRM2-like; 1.
DR InterPro; IPR013170; mRNA_splic_Cwf21_dom.
DR InterPro; IPR029360; SRRM_C.
DR PANTHER; PTHR36562:SF5; RHODANESE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR36562; SERINE/ARGININE REPETITIVE MATRIX 2; 1.
DR Pfam; PF08312; cwf21; 1.
DR Pfam; PF15230; SRRM_C; 1.
DR SMART; SM01115; cwf21; 1.
PE 1: Evidence at protein level;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q9W0B0};
KW Reference proteome {ECO:0000313|Proteomes:UP000000803}.
FT DOMAIN 57..102
FT /note="CWF21"
FT /evidence="ECO:0000259|SMART:SM01115"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 180..697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 718..889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 945..1071
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1083..1107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..223
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..267
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 296..315
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..496
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 506..672
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 721..749
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 757..850
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 958..973
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 983..1038
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1107 AA; 127280 MW; 32422B865E6918CE CRC64;
MYNGIGLTTP RGSGTNGHVQ RNWACVRPGK KDKDYRAEDD TKKLDAQLNR PPNKEILDHD
RKRKIEVKCL ELEDILEKQG RTPEEIKSQV DSFRQKLMGQ GKTDLAKDEF GRVAARDTHQ
IAEAQQQKNA RLREAFNISE YFVEGSSFDG DRKAKEDLAK SVALQKELDA QRESLAAAAA
AAAAGKDKET GKRYALVRTP SRERDRDAGD AAANGDERDH VSKTDKKKRK KRARESSASP
ERKKKKKSKK HKKESKSKKK RSRKRKHSES GRDSDRDSDE EDDSSEEERR ESKNVRKKAK
KDKKKRDKKL KKKSRARASS SDSERTNSPS RKENKSDRSR GAKASKSDEK APQQENVMRS
RSRERKDTRS SRPLEASIDS RQRKPRERSA ATPPRKEPER HRERSKDRQR SKEKHRSRDR
LRSRERQRSR ERQRSRERQR SKERQRSKER QRSIERQRSK ERQRSKERQR SRSKDALRCK
EKPQCNEKER SRERRRSKSK DRQRSKEKHR PKDEQQSVDK RRDRSTDRSK ENQRSNERQR
SKERQRSKER ERSKDRQRSR ERRRSKEGQL SKDRQGLKER QRSNERKRSK ERQPSKEKQR
SRERQRSREP LQSKDRQRSK ERQRSRERPA KEARPTRSPR ERSSKSRDDR RHRSPTNASR
KQKDDTKLSR NARFKSPAHS PEAPPKKSVP TPAFNPFKAA EDTVNDILGT KSVMVALEQT
KRQRAASSSS SDSDSSGSSS TSSRTPSPKP TPRKQKKRSK TPELKEVKKE ISPRKESRVS
VKREQSNSPQ KSKSKSKVDE SSPKRTSRRS RSISSELRYS PAERHPERYH DIVQDKKRPS
KVREAHSTKP APVVRLRAQS DDGSDAETGV DGAALEEFQQ SRREREEQQE LRMLEQLKSG
IAAKAKQKIK IMEKDPAKEG SEPLVAALAD SSLVDAIVSK VSTATVAAAE SAARRSRSRE
RRSRSKRRTS TSHHRHDSSS ESRSRYSSSS SRSGSHSSRS GSHSSRTSCS TNSSSGSSSS
GSGSGSSQSG SRSPSIPRRR GSPSFLDRRR ITSARKRPIP YHHKANAEGE VEDASSCCSS
CFSRASSPAT PLLTPLRNSR SPSMAAF
//
