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Database: UniProt
Entry: Q9W4E6_DROME
LinkDB: Q9W4E6_DROME
Original site: Q9W4E6_DROME 
ID   Q9W4E6_DROME            Unreviewed;       324 AA.
AC   Q9W4E6;
DT   01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2000, sequence version 1.
DT   16-OCT-2019, entry version 150.
DE   SubName: Full=AT31219p {ECO:0000313|EMBL:AAM29340.1};
DE   SubName: Full=CG6789-PA {ECO:0000313|EMBL:CAR93978.1};
DE   SubName: Full=Regulatory particle non-ATPase 13-related {ECO:0000313|EMBL:AAF46007.1};
GN   Name=Rpn13R {ECO:0000313|EMBL:AAF46007.1,
GN   ECO:0000313|FlyBase:FBgn0029745};
GN   Synonyms=Dmel\CG6789 {ECO:0000313|EMBL:AAF46007.1};
GN   ORFNames=CG6789 {ECO:0000313|EMBL:AAF46007.1,
GN   ECO:0000313|FlyBase:FBgn0029745}, Dmel_CG6789
GN   {ECO:0000313|EMBL:AAF46007.1};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227 {ECO:0000313|EMBL:AAF46007.1, ECO:0000313|Proteomes:UP000000803};
RN   [1] {ECO:0000313|EMBL:AAF46007.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA   Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D.,
RA   Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L.,
RA   Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D.,
RA   Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA   Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA   Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA   Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA   Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA   de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA   Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA   Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA   Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA   Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J.,
RA   Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C.,
RA   Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA   Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z.,
RA   Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X.,
RA   Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA   Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA   Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA   Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA   Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA   Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA   Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA   Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA   Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J.,
RA   Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA   Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O.,
RA   Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2] {ECO:0000313|EMBL:AAF46007.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537568;
RA   Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA   Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA   George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA   Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA   Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA   Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT   "Finishing a whole-genome shotgun: release 3 of the Drosophila
RT   melanogaster euchromatic genome sequence.";
RL   Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN   [3] {ECO:0000313|EMBL:AAF46007.1, ECO:0000313|Proteomes:UP000000803}
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA   Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA   Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a
RT   systematic review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4] {ECO:0000313|EMBL:AAF46007.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537573;
RA   Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA   Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M.,
RA   Ashburner M., Celniker S.E.;
RT   "The transposable elements of the Drosophila melanogaster euchromatin:
RT   a genomics perspective.";
RL   Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002).
RN   [5] {ECO:0000313|EMBL:AAF46007.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537574;
RA   Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA   Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA   Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA   Karpen G.H.;
RT   "Heterochromatic sequences in a Drosophila whole-genome shotgun
RT   assembly.";
RL   Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN   [6] {ECO:0000313|EMBL:AAM29340.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.,
RA   Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E.,
RA   George R., Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G.,
RA   Miranda A., Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S.,
RA   Patel S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M.,
RA   Celniker S.;
RL   Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:AAF46007.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA   Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA   Ashburner M., Anxolabehere D.;
RT   "Combined evidence annotation of transposable elements in genome
RT   sequences.";
RL   PLoS Comput. Biol. 1:166-175(2005).
RN   [8] {ECO:0000313|EMBL:AAF46007.1}
RP   NUCLEOTIDE SEQUENCE.
RG   Berkeley Drosophila Genome Project;
RA   Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R.,
RA   Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E.,
RA   Yu C., Rubin G.;
RT   "Drosophila melanogaster release 4 sequence.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|EMBL:AAF46007.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S.,
RA   Svirskas R., Rubin G.;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN   [10] {ECO:0000313|EMBL:AAF46007.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569856; DOI=10.1126/science.1139815;
RA   Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT   "The Release 5.1 annotation of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1586-1591(2007).
RN   [11] {ECO:0000313|EMBL:AAF46007.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569867; DOI=10.1126/science.1139816;
RA   Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA   Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA   Dimitri P., Karpen G.H., Celniker S.E.;
RT   "Sequence finishing and mapping of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1625-1628(2007).
RN   [12] {ECO:0000313|EMBL:CAR93978.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=MEL02 {ECO:0000313|EMBL:CAR93978.1}, MEL11
RC   {ECO:0000313|EMBL:CAR93979.1}, MEL14 {ECO:0000313|EMBL:CAR93982.1},
RC   MEL15 {ECO:0000313|EMBL:CAR93983.1}, MEL18
RC   {ECO:0000313|EMBL:CAR93986.1}, and MEL19
RC   {ECO:0000313|EMBL:CAR93987.1};
RX   PubMed=19126864; DOI=10.1093/molbev/msn297;
RA   Parsch J., Zhang Z., Baines J.F.;
RT   "The influence of demography and weak selection on the McDonald-
RT   Kreitman test: an empirical study in Drosophila.";
RL   Mol. Biol. Evol. 26:691-698(2009).
RN   [13] {ECO:0000313|EMBL:AAF46007.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=26109357; DOI=.1534/g3.115.018929;
RG   FlyBase Consortium;
RA   Matthews B.B., Dos Santos G., Crosby M.A., Emmert D.B.,
RA   St Pierre S.E., Gramates L.S., Zhou P., Schroeder A.J., Falls K.,
RA   Strelets V., Russo S.M., Gelbart W.M.;
RT   "Gene Model Annotations for Drosophila melanogaster: Impact of High-
RT   Throughput Data.";
RL   G3 (Bethesda) 5:1721-1736(2015).
RN   [14] {ECO:0000313|EMBL:AAF46007.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=26109356; DOI=.1534/g3.115.018937;
RG   FlyBase Consortium;
RA   Crosby M.A., Gramates L.S., Dos Santos G., Matthews B.B.,
RA   St Pierre S.E., Zhou P., Schroeder A.J., Falls K., Emmert D.B.,
RA   Russo S.M., Gelbart W.M.;
RT   "Gene Model Annotations for Drosophila melanogaster: The Rule-
RT   Benders.";
RL   G3 (Bethesda) 5:1737-1749(2015).
RN   [15] {ECO:0000313|EMBL:AAF46007.1}
RP   NUCLEOTIDE SEQUENCE.
RG   FlyBase;
RL   Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AE014298; AAF46007.1; -; Genomic_DNA.
DR   EMBL; AY113335; AAM29340.1; -; mRNA.
DR   EMBL; FM246052; CAR93978.1; -; Genomic_DNA.
DR   EMBL; FM246053; CAR93979.1; -; Genomic_DNA.
DR   EMBL; FM246056; CAR93982.1; -; Genomic_DNA.
DR   EMBL; FM246057; CAR93983.1; -; Genomic_DNA.
DR   EMBL; FM246060; CAR93986.1; -; Genomic_DNA.
DR   EMBL; FM246061; CAR93987.1; -; Genomic_DNA.
DR   RefSeq; NP_572205.1; NM_131977.2.
DR   SMR; Q9W4E6; -.
DR   IntAct; Q9W4E6; 2.
DR   STRING; 7227.FBpp0070709; -.
DR   PRIDE; Q9W4E6; -.
DR   EnsemblMetazoa; FBtr0070741; FBpp0070709; FBgn0029745.
DR   GeneID; 31433; -.
DR   KEGG; dme:Dmel_CG6789; -.
DR   UCSC; CG6789-RA; d. melanogaster.
DR   CTD; 31433; -.
DR   FlyBase; FBgn0029745; Rpn13R.
DR   eggNOG; KOG3037; Eukaryota.
DR   eggNOG; ENOG410XSJJ; LUCA.
DR   GeneTree; ENSGT00390000013839; -.
DR   KO; K06691; -.
DR   OMA; MILLGKM; -.
DR   OrthoDB; 1479349at2759; -.
DR   GenomeRNAi; 31433; -.
DR   Proteomes; UP000000803; Chromosome X.
DR   Bgee; FBgn0029745; Expressed in 11 organ(s), highest expression level in testis.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; ISS:FlyBase.
DR   GO; GO:0061133; F:endopeptidase activator activity; IBA:GO_Central.
DR   GO; GO:0070628; F:proteasome binding; IBA:GO_Central.
DR   GO; GO:0043130; F:ubiquitin binding; ISS:FlyBase.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; ISS:FlyBase.
DR   Gene3D; 2.30.29.70; -; 1.
DR   Gene3D; 3.40.190.140; -; 1.
DR   InterPro; IPR006773; Rpn13/ADRM1.
DR   InterPro; IPR038633; Rpn13/ADRM1_sf.
DR   InterPro; IPR032368; RPN13_C.
DR   InterPro; IPR038108; RPN13_C_sf.
DR   PANTHER; PTHR12225; PTHR12225; 1.
DR   Pfam; PF04683; Proteasom_Rpn13; 1.
DR   Pfam; PF16550; RPN13_C; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000803};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000803}.
FT   DOMAIN      206    310       RPN13_C. {ECO:0000259|Pfam:PF16550}.
SQ   SEQUENCE   324 AA;  36472 MW;  3C7941889013FB02 CRC64;
     MAQSNAHNLV EYKAGRMVLL GKMVEPDDRK GLLFVRRSAD DNQLHIHWMD RRSGSVELDI
     VATPGVLEFR RIDQCKTGRV YVLKYTRSTQ RYFFWMQELQ ADGDALFCQR VNELIASGER
     QRDEIAAAEG DMDTDADHTT ARRGFGGSEN PQILEEMLVE TQATWLPANR SLNHWQTGDA
     MEEPPLPFAD PDANTDTDTD TYTSESGIQT FDLAAVLRLH GAEAVDKVLS CPSRREKLMA
     QLPKDHEAMD EQSDILEHLH SAQFYESLSS FSVGLHSGAL RKSLEPLLQS DDNREALNAA
     QVGDVERFLR ELERNDGDYG GPTD
//
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