GenomeNet

Database: UniProt
Entry: Q9W758
LinkDB: Q9W758
Original site: Q9W758 
ID   CTBP2_XENLA             Reviewed;         437 AA.
AC   Q9W758; Q6DFD9;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   16-JAN-2019, entry version 93.
DE   RecName: Full=C-terminal-binding protein 2;
DE            Short=CtBP2;
DE   AltName: Full=C-terminal-binding protein B;
DE   AltName: Full=TCF-3 corepressor CtBP;
DE   AltName: Full=XCtBP;
GN   Name=ctbp2; Synonyms=ctbp-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC   Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH TCF7L1-A, AND
RP   DEVELOPMENTAL STAGE.
RX   PubMed=10375506;
RA   Brannon M., Brown J.D., Bates R., Kimelman D., Moon R.T.;
RT   "XCtBP is a XTcf-3 co-repressor with roles throughout Xenopus
RT   development.";
RL   Development 126:3159-3170(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Corepressor targeting diverse transcription regulators.
CC       {ECO:0000269|PubMed:10375506}.
CC   -!- SUBUNIT: Interacts with the C-terminus of tcf7l1-a via the
CC       consensus motifs P-X-[DNS]-L-[STVA].
CC       {ECO:0000269|PubMed:10375506}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Expressed throughout development. Localized
CC       to discrete structures during neurulation. The pattern of
CC       expression is increasingly refined to include the head, central
CC       nervous system and tissues along the dorsal midline to the
CC       tailbud. {ECO:0000269|PubMed:10375506}.
CC   -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC       dehydrogenase family. {ECO:0000305}.
DR   EMBL; AF152006; AAD41370.1; -; mRNA.
DR   EMBL; BC076800; AAH76800.1; -; mRNA.
DR   RefSeq; NP_001081966.1; NM_001088497.1.
DR   RefSeq; XP_018109637.1; XM_018254148.1.
DR   UniGene; Xl.41670; -.
DR   ProteinModelPortal; Q9W758; -.
DR   SMR; Q9W758; -.
DR   GeneID; 398147; -.
DR   KEGG; xla:398147; -.
DR   CTD; 398147; -.
DR   Xenbase; XB-GENE-6251928; ctbp2.
DR   HOVERGEN; HBG001898; -.
DR   KO; K04496; -.
DR   OrthoDB; 700058at2759; -.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0050872; P:white fat cell differentiation; ISS:UniProtKB.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR   InterPro; IPR029753; D-isomer_DH_CS.
DR   InterPro; IPR029752; D-isomer_DH_CS1.
DR   InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00389; 2-Hacid_dh; 1.
DR   Pfam; PF02826; 2-Hacid_dh_C; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
DR   PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE   1: Evidence at protein level;
KW   Nucleus; Oxidoreductase; Repressor; Transcription;
KW   Transcription regulation; Wnt signaling pathway.
FT   CHAIN         1    437       C-terminal-binding protein 2.
FT                                /FTId=PRO_0000076047.
FT   NP_BIND     183    188       NAD. {ECO:0000250}.
FT   NP_BIND     240    246       NAD. {ECO:0000250}.
FT   NP_BIND     267    269       NAD. {ECO:0000250}.
FT   NP_BIND     318    321       NAD. {ECO:0000250}.
FT   ACT_SITE    269    269       {ECO:0000250}.
FT   ACT_SITE    298    298       {ECO:0000250}.
FT   ACT_SITE    318    318       Proton donor. {ECO:0000250}.
FT   BINDING     103    103       NAD. {ECO:0000250}.
FT   BINDING     207    207       NAD. {ECO:0000250}.
FT   BINDING     293    293       NAD. {ECO:0000250}.
SQ   SEQUENCE   437 AA;  47776 MW;  49D2FEFD82E2B010 CRC64;
     MDKHKVKRQR LDRICDGIRP PILNGPMPVR PLVALLDGRD CTIEMPILKD VATVAFCDAQ
     STQEIHEKVL SEAVGALMYH TITLSREDLE KFKALRIIIK IGSGYDNIDI KSAAELGIAV
     CNIPSASVEE TADSTLCHIL NLYRRVTWLH QAMREGNRPA SVEQIREVAG GAARIRGETL
     GIIGLGRIGQ AVALRAKAFN FTVIFYDPYL ADGVERSLGL QRMATLQELL MHSDCITLHC
     NLNEHNHHLI NDFTIKQMRQ GCFLVNTARG GLVDEKALAQ ALKDGRIRGA ALDVHESEPF
     SFSQGPLKDA PNLICTPHTA WYSEHASIEA REEAAKEIRR AIAGPIPDSL RNCVNKDYLL
     AAVQWSGMEQ AAVHPELNGA SSYRFPPGVV GVTSAGHPSA IEGLVASSHP LIPSVSHTPS
     PGQTTKPDPD REIPTDQ
//
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