ID Q9WJ28_PTV1F Unreviewed; 2236 AA.
AC Q9WJ28;
DT 01-NOV-1999, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1999, sequence version 1.
DT 27-MAR-2024, entry version 150.
DE RecName: Full=Genome polyprotein {ECO:0000256|ARBA:ARBA00020107};
OS Porcine teschovirus 1 (isolate Pig/United Kingdom/F65/1967) (PTV-1)
OS (Porcine teschovirus 1 (isolate F65)).
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Picornavirales; Picornaviridae; Caphthovirinae; Teschovirus; Teschovirus A.
OX NCBI_TaxID=650136 {ECO:0000313|EMBL:CAB40546.1, ECO:0000313|Proteomes:UP000000408};
OH NCBI_TaxID=9823; Sus scrofa (Pig).
RN [1] {ECO:0000313|EMBL:CAB40546.1, ECO:0000313|Proteomes:UP000000408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate Pig/United Kingdom/F65/1967
RC {ECO:0000313|Proteomes:UP000000408};
RX PubMed=10466788;
RA Doherty M., Todd D., McFerran N., Hoey E.M.;
RT "Sequence analysis of a porcine enterovirus serotype 1 isolate:
RT relationships with other picornaviruses.";
RL J. Gen. Virol. 80:1929-1941(1999).
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004180}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004180}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004180}. Host cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004295}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004295}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004295}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR EMBL; AJ011380; CAB40546.1; -; Genomic_RNA.
DR RefSeq; NP_653143.1; NC_003985.1.
DR GeneID; 944576; -.
DR KEGG; vg:944576; -.
DR Proteomes; UP000000408; Segment.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044162; C:host cell cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019030; C:icosahedral viral capsid; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0051259; P:protein complex oligomerization; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR GO; GO:0039707; P:virus-mediated pore formation in host cell membrane; IEA:UniProtKB-KW.
DR CDD; cd00205; rhv_like; 3.
DR CDD; cd23212; Teschovirus_RdRp; 1.
DR Gene3D; 1.20.960.20; -; 1.
DR Gene3D; 2.60.120.20; -; 3.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 4.10.90.10; Capsid protein VP4 superfamily, Picornavirus; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR015031; Capsid_VP4_Picornavir.
DR InterPro; IPR037080; Capsid_VP4_sf_Picornavirus.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR022098; DUF3637.
DR InterPro; IPR000605; Helicase_SF3_ssDNA/RNA_vir.
DR InterPro; IPR014759; Helicase_SF3_ssRNA_vir.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR044067; PCV_3C_PRO.
DR InterPro; IPR000199; Peptidase_C3A/C3B_picornavir.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001676; Picornavirus_capsid.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR033703; Rhv-like.
DR InterPro; IPR001205; RNA-dir_pol_C.
DR InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR InterPro; IPR029053; Viral_coat.
DR Pfam; PF12337; DUF3637; 1.
DR Pfam; PF00548; Peptidase_C3; 1.
DR Pfam; PF00680; RdRP_1; 1.
DR Pfam; PF00073; Rhv; 2.
DR Pfam; PF00910; RNA_helicase; 1.
DR Pfam; PF08935; VP4_2; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF88633; Positive stranded ssRNA viruses; 2.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS51874; PCV_3C_PRO; 1.
DR PROSITE; PS50507; RDRP_SSRNA_POS; 1.
DR PROSITE; PS51218; SF3_HELICASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Capsid protein {ECO:0000256|ARBA:ARBA00022561};
KW Covalent protein-RNA linkage {ECO:0000256|ARBA:ARBA00022520};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Host cytoplasm {ECO:0000256|ARBA:ARBA00023200};
KW Host cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00022488};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000000408};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW Viral ion channel {ECO:0000256|ARBA:ARBA00023039};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953};
KW Virion {ECO:0000256|ARBA:ARBA00022804};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT TRANSMEM 1065..1083
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1531..1552
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1232..1396
FT /note="SF3 helicase"
FT /evidence="ECO:0000259|PROSITE:PS51218"
FT DOMAIN 1584..1773
FT /note="Peptidase C3"
FT /evidence="ECO:0000259|PROSITE:PS51874"
FT DOMAIN 2012..2124
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50507"
SQ SEQUENCE 2236 AA; 250488 MW; CC0CD35E6FF8B8B4 CRC64;
MEFLYGNAGL DLCCLTGSRL AVCTLYSQLK LTMACLKIFS LKRKDKSHSY SPREIELKYN
SDFAFKPRPL APLLRLEPSD TTTRRIECAE VEYDLWYPNP LDPASLVCDV KLEMLRFQGT
GTSRMENGNT NNSGNTGVIN YNFYSNSYTD AVDLSGAMSS QESNAAENAA SGPTSLLKAG
INAAARIGPL LAEPKFEEYK LSDRVDVLQK GTSTIISQNS VGSNTYVSCP KFDVTSVADE
GTSGGPAVSR FVTLRAQSWS TSQDVYSFQA AHLPYALVAQ ETPFKALMSK HQLLKCGWIV
QVQINTTRFH GGCIGVFAVP EFSVFSRPDG QLTYTNNRGG SPSDIWDKFS KWHNPDKMYS
TWHYHHTFDD TDKHWYKPEE QPYGGISPQS LFCFPHQLIN PRTNSSATLC VPYVDCGPIT
DVTVHCPWAI VIVVLRQLLV ANGGTPSVDI NVSLAPCNVE YHGLRQSSVY QSPIPKADID
ASRALFSTTQ PYTAAPVYGK IPASSPSYMP GEFLDYVQLA QIPCLVKNRE IRVSSTERTK
PIFGMPLRPV NDETTNTMLG SVTRMFTQWR GSLVIRCVFV GNQMQNCRLV LAWTSQGFNA
PMPTTMAEAM QGHYVIYDTG VDSSVDLVVP YVAPYDFTPV RTPYTKTDFP MLPNSDPVLV
DTPYWSKGYV TIWQYTNLAS PPNSPALADF LLFVFAGEDY VLKGPSNISS GFQGNMDSPL
QPAETGCDKA MAPSASNENP VPLSVESIGS SRVSFFWDRY FHISTITKMT NVDPQYLRLN
ISDILRDPVI RQSLHATYLR CGLSVAVRVM PANPASTECL DGLTLNLLYV PPGSGWNIDK
LSATDPIEKA KDSVDNYALP SFTWKPAQTP VFTCSVPYVS FNSVLPAMYS GFETSSKIPK
RNNQIPQDFG FGMLVLRSSS TAGLAVSVWV KFENVRLFCP RPGIHDPLAY SRSHPQESRE
HDEGLSSAMT VMAFQGPGAT NFSLLKQAGD VEENPGPSLS KLYQILKDPA VDALCEAYDE
LKKFKEQATN LLDSFSGDSE NPWLNKFIKY LGYAILAWKS LHDPMTAAAV CFIIGSDVTA
FVVSKLAKHL KKFAKTDSPP VPKPRSCKKE GCCCGNKHNY PDELNPFSEN GFWSRFKKGH
LQGPMQDVSS LINILKGAEW IYHQFEKVIK WLKTWRTAEY EVSSDYLQNE MKNYPHYHRK
YKECANNYRH PDRTEVANYF KKMRKCAAHV NPRLMGMFPE FDPSPPDPTR PEPVVVVLRG
APGQGKSVCS EMLARMLSYT LVGKSSYYAF NSATKHFDGY KQQAVTIIDD LGQDTSGEDF
RLFCQLVSTT ECIVPMADLP DKGMHFKSEI LIANTNLPSF NPITVSDPAA IKRRIFLDLT
VEANRAYTKP DGTLDLVRAL QATGKESQSP LLRQDHNILY SDCVAFKHGR HTLSFLEVFD
MIKRELQRRQ NVSNSLTNLF TFQGPNDDSW FTTFYKKWNL RAKENSEEKL ILELIRYCHG
SEMLKEYCQL AAANKEKKTG YWNMVRIIEE ILAALTLILS LISIMIVMYQ LFFQGSYEAT
AIKPTKPNRQ SLLKLVEMQG PKGQANMEME RTLMKKNIVE MTYEKHNGRF QTTTVLFVRD
RIFLINTHIL SSIKNFHYEN TEIPAASVQK VQAIFDGHPS DVTAVQFTVG RQYRDITSNF
IISLPNPGTP IVGLMKTEGS SYIWSGECLP FKNTMNTYEG CVPHVLPYKA VTAHGYCGSV
MVADAGVWKG ICGIHSLGDG AIGAATVLSR QHLLNLLEGF LEFQGKIYDV QKTDFVYTPT
RTSLKPTFVC VDPKLEPAAL SHLDPRLKEP ENFKAVILSK HVGDSLQLPW GIRWASYKYA
ERIRAMLPPD FLEPLSVREA VEGIDGLDPM DMDKSPGLPY VKKGLRRTDL WNPKTGSSLE
LMAEINRYLD YNYDKHVFLT FLKDELRPKE KVQAGKTRVI DVAGFGHAIV GRMLFGRLFA
FFHKNPGWNT GSAVGVNPDL AWTQIFYTAP SRNVLAMDYS GFDASHTSGM FCILKHFLTT
LGYGTLQLSY IDSLCYSKHH WDDETYRLDG GLPSGCSGTT IFNTIMNNIV ARAAASYAAD
GPVGILCYGD DILVSSPEKF PVSDWLEFYS KTPYKVTAAD KSEQIDWRDI TQCTFLKRGF
VLDGSLVRPV MEEQHLAELL KWARPGTLQA KLLSIAQLAF HLPRSAYNRL MLPFEEAGYE
IPSHERLNEE WREMFI
//
