ID Q9WJD7_9VIRU Unreviewed; 1858 AA.
AC Q9WJD7;
DT 01-NOV-1999, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1999, sequence version 1.
DT 28-JUN-2023, entry version 115.
DE RecName: Full=Replicase large subunit {ECO:0000256|ARBA:ARBA00013540};
OS Chinese wheat mosaic virus.
OC Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC Martellivirales; Virgaviridae; Furovirus.
OX NCBI_TaxID=83544 {ECO:0000313|EMBL:CAB41769.1, ECO:0000313|Proteomes:UP000203429};
RN [1] {ECO:0000313|EMBL:CAB41769.1, ECO:0000313|Proteomes:UP000203429}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10355760;
RA Diao A., Chen J., Ye R., Zheng T., Yu S., Antoniw J.F., Adams M.J.;
RT "Complete sequence and genome properties of Chinese wheat mosaic virus, a
RT new furovirus from China.";
RL J. Gen. Virol. 80:1141-1145(1999).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR EMBL; AJ012005; CAB41769.1; -; Genomic_RNA.
DR RefSeq; NP_059513.1; NC_002359.1.
DR GeneID; 995384; -.
DR KEGG; vg:995384; -.
DR Proteomes; UP000203429; Genome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008174; F:mRNA methyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR CDD; cd23251; Virgaviridae_RdRp; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027351; (+)RNA_virus_helicase_core_dom.
DR InterPro; IPR002588; Alphavirus-like_MT_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001788; RNA-dep_RNA_pol_alsuvir.
DR InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR InterPro; IPR047310; Virgaviridae_RdRp.
DR InterPro; IPR013664; Virgavirus_MeTrfase_C.
DR Pfam; PF00978; RdRP_2; 1.
DR Pfam; PF01443; Viral_helicase1; 1.
DR Pfam; PF01660; Vmethyltransf; 1.
DR Pfam; PF08456; Vmethyltransf_C; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51743; ALPHAVIRUS_MT; 1.
DR PROSITE; PS51657; PSRV_HELICASE; 1.
DR PROSITE; PS50507; RDRP_SSRNA_POS; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953}.
FT DOMAIN 82..302
FT /note="Alphavirus-like MT"
FT /evidence="ECO:0000259|PROSITE:PS51743"
FT DOMAIN 1026..1350
FT /note="(+)RNA virus helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51657"
FT DOMAIN 1611..1724
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50507"
SQ SEQUENCE 1858 AA; 212254 MW; 2325AED1F2CC5C28 CRC64;
MPIDSSSILG IISEEDVIRA AISTSATKFG SQLHSTVCDH VKETYLDAME RQKTKKKIDV
RRDLSQEQLQ LLNDLYPERH IVSSNCERGT HSFAAASRKI ETDLLLSRIP KKSWVYDIGG
NWATHIKRND GRRVHCCCPT IDIRDSARKT VSWASIEKYL DEKDEIPTEV GERIKRVQAD
EIKIYENLKN KRAQPEDLDG KWYCGNKFEE CVFRAERAYA MAIHSIYDID LMDLANALEE
KRIKIMSGTF LFSVDLLLGK KSGSLPTMDG FFEVEGDYVK YGFKNDTNPG YKHKLSQLMK
YLTKTFVVAK GGTIYYLELT EQRGDVMFFT MTDATEARMN GVVADESFKC IPIDNKSEVV
FPIFEVDKQT DSLIFSEVLL SKDFVQRAIE FTGRLKPNQL TPDNVNTYLT STNNTIIIGG
SSKKNTTKVD ATLIQQITTT LVVWTELMNL RQKRVLEKLR LQMKDDVDFK SLAHTAFLKV
FGKVSYYQRA LRCFANWLSY VHGTDAIQFH DVPLYAEVTD RVKLWKTHAP NQGFVLDMED
LDVKIKMHEV SEREKRDVSR CIVSGKLGEL QIHSESSNNE EQINGDYRDS RRRTTFEDLL
EGEVATNFLD DWCEKNDHFN FSRDDAQSKY AWGLKLLKGI WEFLLPPMDF APVYVDDEQA
RLRMVRVNER RNTSDTGADG DVAACEVAAD FSKAMDTLVD VVKKMDQKKL GLVEKVKASA
VAVVELSKTK PVTGNSCAVD LWADFEKNLD DDDEPGCGIS VVTKGKEICQ DNVGPVLLCG
SSSCSSVSEV EKETDVVSVT DSGNSPATCC GGMVLDKSVS IAGNDVSVEL PVTATTVATV
ETGTADGVIA STDESAFSDV NDKSWGSVAE EESDDTFYSC SGLISDKVKK SNLPKRPDFS
KFPTVQQKAK HEAMWYLQCK IVSDRTTLRS IIDDHLRGMF HNGTCELPKD SAFLDYTADN
CGTWMYGKPS RFGHSYGVGF SLDTRQRVSK CELVKLMWNH DSRGQVNQKP VNTRAFQYLL
LSELSFMMNE MIIYRNLQQV MRKRERSKQA RITLRDGVPG CGKSTWILNN ANPTKDMILS
VGKEATEDLK EKFMKKHRCV ESDLKRIRTV DSFLMHDYDK YRAATVHFDE ALMAHAGMVY
FCADILGAKK VICQGDSQQI PFINRVESIT LQYSKLVIDE TEHVRLTYRS PVDVAHYLTK
KSWYSGGRVT TKNPVMRSMK TVGPRDVKPM TSVHCVPYFK DAQYLTFTQS EKTDLYKALR
NKGPVTVNTV HETQGKTFDD VIVVRLETTE NEIYPGGRKG QPYEIVATTR HRRSLVYYTA
IEDRLFEDIS DMQDVMESKL MKSLCPEFDK XRFGSKYESI LICDREVRVP DVGTPAILQD
FYDRVFPGNS TMDSHFDGYE VSTSDISIEL ENCTVQPNKN VRVWQDKRGL VPVMRTAMPP
KRQNLPVEAM LALKKRNMAA PKLQEAVNEF EVIERTINRA KEIFFNVELI DDSELSTRES
NLRWWGRQST TARAQMKKEM RVLHEIDLCF YSYNIKGDEK PKMDRSPQHE YGALQTVVFP
DKIVNALFGP VMKEINERIR MALKPHVVYN SRMNADELNR TVEFLDPDEE YNAFEIDFSK
FDKSKTSLHI RAVIELYKLF GLNDLIALLW EKSQSRTKIR DFVYGITAYL LYQQKSGNCD
TYGSNTWSAA LALLESMPLE KAKFMIFGGD DSLILFPKQQ VVEDPCRRLA SLWNFDCKLF
DFKHNMFCGK FLLKIGDRFK FAPDPMKLIT KLGRKDIADG RLLSEIFVSI GDNFRSYRDY
RILEQLSLAV RERYKTDEDP TATLITLKKY IFDFKLWGSL FNYSGEFVES RVDRNFEW
//
