GenomeNet

Database: UniProt
Entry: Q9WTP3
LinkDB: Q9WTP3
Original site: Q9WTP3 
ID   SPDEF_MOUSE             Reviewed;         325 AA.
AC   Q9WTP3;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   07-OCT-2020, entry version 158.
DE   RecName: Full=SAM pointed domain-containing Ets transcription factor;
DE   AltName: Full=Prostate epithelium-specific Ets transcription factor;
DE            Short=Prostate-specific Ets;
DE   AltName: Full=Prostate-derived Ets factor;
GN   Name=Spdef; Synonyms=Pdef, Pse;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC   STRAIN=C57BL/6J; TISSUE=Colon;
RX   PubMed=10675039; DOI=10.1016/s0378-1119(99)00484-9;
RA   Yamada N., Tamai Y., Miyamoto H., Nozaki M.;
RT   "Cloning and expression of the mouse Pse gene encoding a novel Ets family
RT   member.";
RL   Gene 241:267-274(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Colon;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Colon;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May function as an androgen-independent transactivator of the
CC       prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA
CC       sequences. May play a role in the regulation of the prostate gland
CC       and/or prostate cancer development. Acts as a transcriptional activator
CC       for SERPINB5 promoter (By similarity). {ECO:0000250,
CC       ECO:0000269|PubMed:10675039}.
CC   -!- SUBUNIT: Interacts with the DNA-binding domain of the androgen
CC       receptor. Interacts with NKX3-1 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in the accessory glands of sex organs
CC       including the prostate, seminal vesicle, coagulating gland in males,
CC       the oviduct in females, and in intestines. Expression is epithelial-
CC       specific. {ECO:0000269|PubMed:10675039}.
CC   -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
DR   EMBL; AB019436; BAA77329.1; -; mRNA.
DR   EMBL; AK078863; BAC37426.1; -; mRNA.
DR   EMBL; BC012648; AAH12648.1; -; mRNA.
DR   CCDS; CCDS28568.1; -.
DR   RefSeq; NP_038919.1; NM_013891.4.
DR   RefSeq; XP_006524442.1; XM_006524379.3.
DR   RefSeq; XP_006524443.1; XM_006524380.3.
DR   RefSeq; XP_006524444.1; XM_006524381.3.
DR   RefSeq; XP_017172988.1; XM_017317499.1.
DR   SMR; Q9WTP3; -.
DR   BioGRID; 205953; 2.
DR   STRING; 10090.ENSMUSP00000110520; -.
DR   PhosphoSitePlus; Q9WTP3; -.
DR   PaxDb; Q9WTP3; -.
DR   PRIDE; Q9WTP3; -.
DR   Antibodypedia; 15077; 217 antibodies.
DR   Ensembl; ENSMUST00000025054; ENSMUSP00000025054; ENSMUSG00000024215.
DR   Ensembl; ENSMUST00000167489; ENSMUSP00000127056; ENSMUSG00000024215.
DR   GeneID; 30051; -.
DR   KEGG; mmu:30051; -.
DR   UCSC; uc008bpo.2; mouse.
DR   CTD; 25803; -.
DR   MGI; MGI:1353422; Spdef.
DR   eggNOG; KOG3805; Eukaryota.
DR   GeneTree; ENSGT00940000157549; -.
DR   HOGENOM; CLU_877059_0_0_1; -.
DR   InParanoid; Q9WTP3; -.
DR   KO; K09442; -.
DR   OMA; CFDMLLT; -.
DR   OrthoDB; 908495at2759; -.
DR   PhylomeDB; Q9WTP3; -.
DR   TreeFam; TF318679; -.
DR   BioGRID-ORCS; 30051; 2 hits in 20 CRISPR screens.
DR   PRO; PR:Q9WTP3; -.
DR   Proteomes; UP000000589; Chromosome 17.
DR   RNAct; Q9WTP3; protein.
DR   Bgee; ENSMUSG00000024215; Expressed in head and 128 other tissues.
DR   ExpressionAtlas; Q9WTP3; baseline and differential.
DR   Genevisible; Q9WTP3; MM.
DR   GO; GO:0042025; C:host cell nucleus; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISO:MGI.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0060576; P:intestinal epithelial cell development; IMP:MGI.
DR   GO; GO:0060480; P:lung goblet cell differentiation; IDA:MGI.
DR   GO; GO:0010454; P:negative regulation of cell fate commitment; IMP:MGI.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:MGI.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; ISO:MGI.
DR   GO; GO:0010455; P:positive regulation of cell fate commitment; IMP:MGI.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..325
FT                   /note="SAM pointed domain-containing Ets transcription
FT                   factor"
FT                   /id="PRO_0000223959"
FT   DOMAIN          119..203
FT                   /note="PNT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00762"
FT   DNA_BIND        239..322
FT                   /note="ETS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
SQ   SEQUENCE   325 AA;  36356 MW;  B55CF6CEC4501125 CRC64;
     MGSASPGLSN VSPGCLLLFP DVAPRTGTEK AASGAMGPEK QEWSPSPPAT PEQGLSAFYL
     SYFNMYPDDS SWVAKVPEAR AGEDHPEEPE QCPVIDSQAS GSTLDEHSLE QVQSMVVGEV
     LKDIETACKL LNITADPGDW SPGNVQKWLL WTEHQYRLPP AGKAFQELGG KELCAMSEEQ
     FRQRAPLGGD VLHAHLDIWK SAAWMKERTS PGTLHYCAST SEEGWTDGEV DSSCSGQPIH
     LWQFLKELLL KPHSYGRFIR WLNKEKGIFK IEDSAQVARL WGVRKNRPAM NYDKLSRSIR
     QYYKKGIIRK PDISQRLVYQ FVHPV
//
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