ID B2MG_CRIGR Reviewed; 119 AA.
AC Q9WV24;
DT 30-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE RecName: Full=Beta-2-microglobulin;
DE Flags: Precursor;
GN Name=B2M;
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Gastinel L.N.;
RT "cDNA sequence of CHO-KI hamster beta2-microglobulin.";
RL Submitted (JAN-1991) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the class I major histocompatibility complex
CC (MHC). Involved in the presentation of peptide antigens to the immune
CC system (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain. Beta-2-
CC microglobulin is the beta-chain of major histocompatibility complex
CC class I molecules (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the beta-2-microglobulin family. {ECO:0000305}.
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DR EMBL; X57112; CAA40395.1; -; mRNA.
DR RefSeq; NP_001233603.1; NM_001246674.2.
DR AlphaFoldDB; Q9WV24; -.
DR SMR; Q9WV24; -.
DR PaxDb; 10029-NP_001233603-1; -.
DR Ensembl; ENSCGRT00000017702; ENSCGRP00000017448; ENSCGRG00000012690.
DR Ensembl; ENSCGRT00001022765.1; ENSCGRP00001018521.1; ENSCGRG00001018239.1.
DR GeneID; 100689409; -.
DR KEGG; cge:100689409; -.
DR CTD; 567; -.
DR eggNOG; ENOG502S8GM; Eukaryota.
DR GeneTree; ENSGT00690000102227; -.
DR OMA; HEWDADV; -.
DR OrthoDB; 4629494at2759; -.
DR Proteomes; UP000694386; Unplaced.
DR Proteomes; UP001108280; Chromosome 6.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:Ensembl.
DR GO; GO:0042824; C:MHC class I peptide loading complex; IEA:Ensembl.
DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0005198; F:structural molecule activity; IEA:Ensembl.
DR GO; GO:1990000; P:amyloid fibril formation; IEA:Ensembl.
DR GO; GO:0019885; P:antigen processing and presentation of endogenous peptide antigen via MHC class I; IEA:Ensembl.
DR GO; GO:0002481; P:antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; IEA:Ensembl.
DR GO; GO:0071283; P:cellular response to iron(III) ion; IEA:Ensembl.
DR GO; GO:0071316; P:cellular response to nicotine; IEA:Ensembl.
DR GO; GO:0006879; P:intracellular iron ion homeostasis; IEA:Ensembl.
DR GO; GO:0006826; P:iron ion transport; IEA:Ensembl.
DR GO; GO:0007611; P:learning or memory; IEA:Ensembl.
DR GO; GO:0060586; P:multicellular organismal-level iron ion homeostasis; IEA:Ensembl.
DR GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:2000978; P:negative regulation of forebrain neuron differentiation; IEA:Ensembl.
DR GO; GO:0050768; P:negative regulation of neurogenesis; IEA:Ensembl.
DR GO; GO:0010977; P:negative regulation of neuron projection development; IEA:Ensembl.
DR GO; GO:0002502; P:peptide antigen assembly with MHC class I protein complex; IEA:Ensembl.
DR GO; GO:2000774; P:positive regulation of cellular senescence; IEA:Ensembl.
DR GO; GO:0048260; P:positive regulation of receptor-mediated endocytosis; IEA:Ensembl.
DR GO; GO:0002726; P:positive regulation of T cell cytokine production; IEA:Ensembl.
DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IEA:Ensembl.
DR GO; GO:0051289; P:protein homotetramerization; IEA:Ensembl.
DR GO; GO:0042026; P:protein refolding; IEA:Ensembl.
DR GO; GO:0045646; P:regulation of erythrocyte differentiation; IEA:Ensembl.
DR GO; GO:0034756; P:regulation of iron ion transport; IEA:Ensembl.
DR GO; GO:0002237; P:response to molecule of bacterial origin; IEA:Ensembl.
DR GO; GO:0007608; P:sensory perception of smell; IEA:Ensembl.
DR GO; GO:0033077; P:T cell differentiation in thymus; IEA:Ensembl.
DR GO; GO:0001913; P:T cell mediated cytotoxicity; IEA:Ensembl.
DR CDD; cd05770; IgC1_beta2m; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR015707; B2Microglobulin.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR PANTHER; PTHR19944:SF62; BETA-2-MICROGLOBULIN; 1.
DR PANTHER; PTHR19944; MHC CLASS II-RELATED; 1.
DR Pfam; PF07654; C1-set; 1.
DR SMART; SM00407; IGc1; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Immunity; Immunoglobulin domain; MHC I; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000250"
FT CHAIN 21..119
FT /note="Beta-2-microglobulin"
FT /id="PRO_0000018776"
FT DOMAIN 25..114
FT /note="Ig-like C1-type"
FT DISULFID 45..100
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 119 AA; 13788 MW; 28AC3DC1ADFF9274 CRC64;
MARSVAVVFL MLLSVVCLDA IQRPPQVQVY TRHPPEDGKT NFLNCYVSQF HPPQIEIELL
KNGKKMDKVE LSDLSFNKDW SFYLLAHTEF TPTATDKYAC RVTHTTLKEP KVVTWERDM
//
