ID Q9WZ59_THEMA Unreviewed; 557 AA.
AC Q9WZ59; G4FDM9;
DT 01-NOV-1999, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1999, sequence version 1.
DT 27-MAR-2024, entry version 123.
DE SubName: Full=Penicillin-binding protein 2 {ECO:0000313|EMBL:AAD35675.1};
GN OrderedLocusNames=TM_0590 {ECO:0000313|EMBL:AAD35675.1};
OS Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826
OS / MSB8).
OC Bacteria; Thermotogota; Thermotogae; Thermotogales; Thermotogaceae;
OC Thermotoga.
OX NCBI_TaxID=243274 {ECO:0000313|EMBL:AAD35675.1, ECO:0000313|Proteomes:UP000008183};
RN [1] {ECO:0000313|EMBL:AAD35675.1, ECO:0000313|Proteomes:UP000008183}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8
RC {ECO:0000313|Proteomes:UP000008183};
RX PubMed=10360571; DOI=10.1038/20601;
RA Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H.,
RA Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.,
RA Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M.,
RA Cotton M.D., Pratt M.S., Phillips C.A., Richardson D., Heidelberg J.,
RA Sutton G.G., Fleischmann R.D., White O., Salzberg S.L., Smith H.O.,
RA Venter J.C., Fraser C.M.;
RT "Evidence for lateral gene transfer between Archaea and Bacteria from
RT genome sequence of Thermotoga maritima.";
RL Nature 399:323-329(1999).
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DR EMBL; AE000512; AAD35675.1; -; Genomic_DNA.
DR PIR; G72356; G72356.
DR RefSeq; NP_228400.1; NC_000853.1.
DR RefSeq; WP_004081264.1; NZ_CP011107.1.
DR AlphaFoldDB; Q9WZ59; -.
DR PaxDb; 243274-THEMA_01710; -.
DR EnsemblBacteria; AAD35675; AAD35675; TM_0590.
DR KEGG; tma:TM0590; -.
DR KEGG; tmw:THMA_0606; -.
DR PATRIC; fig|243274.17.peg.591; -.
DR InParanoid; Q9WZ59; -.
DR OrthoDB; 9770103at2; -.
DR Proteomes; UP000008183; Chromosome.
DR GO; GO:0008658; F:penicillin binding; IBA:GO_Central.
DR GO; GO:0071972; F:peptidoglycan L,D-transpeptidase activity; IBA:GO_Central.
DR GO; GO:0071555; P:cell wall organization; IBA:GO_Central.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008183}.
FT DOMAIN 209..537
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 557 AA; 61900 MW; DCBF394417124A80 CRC64;
MKNRLILILM ALSFVLIIMK AFQVQILEHE KHKKYIDLLQ TRLVKIPAPR GKIISSDGKV
LAKDEVVYVL DPWLNSIDEL KKTGLFTPEE ILSLVKGESI VIDKARADVI SKAGMRVVMD
YRRKYEPLAP HVVGYVNADR AGVYGVESVY DEFLTGTDGV KMVFVEPSGA ISSEVLRSPP
KPGEDVTLTI DTRIQKVAEE SLEKIGNPGS VILSDVRTGE ILALASFPEY NPQDFYEGFT
KREWERFARN SPSPLINRAI SSAYSPGSSI KILWAVAALL NGVDPEEKIN CRGVFEYRNS
RGEVVARYRD WKEEGHGFTD LRKAIRVSCN VYFYQLGLKL GVDKMVEVAK KLSIFEKTGI
DLPGEKSGTL PSPEWKMSKI GEPWYPGDTI LMSIGQGYLT ATPIELLKLV SLVANEGIFY
RPHVVKRIGS KAVKPEIETQ VQIDEKIWNF IKDAMVDVTS FKGNEKEDPG TAYHVFGDFP
YRVAGKTGTA EAGSGAPHSW FVGFAPAENP EVAIVVMVEH GGYGSGAASQ IARRVLEEYF
KLKESAQETP VSSRSRD
//
