ID Q9XVR3_CAEEL Unreviewed; 178 AA.
AC Q9XVR3;
DT 01-NOV-1999, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1999, sequence version 1.
DT 24-JAN-2024, entry version 145.
DE RecName: Full=protein-disulfide reductase {ECO:0000256|ARBA:ARBA00012612};
DE EC=1.8.1.8 {ECO:0000256|ARBA:ARBA00012612};
GN ORFNames=C30H6.8 {ECO:0000313|EMBL:CAB02808.1,
GN ECO:0000313|WormBase:C30H6.8}, CELE_C30H6.8
GN {ECO:0000313|EMBL:CAB02808.1};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAB02808.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAB02808.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAB02808.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[protein]-dithiol + NAD(+) = [protein]-disulfide + H(+) +
CC NADH; Xref=Rhea:RHEA:18749, Rhea:RHEA-COMP:10593, Rhea:RHEA-
CC COMP:10594, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.8.1.8;
CC Evidence={ECO:0000256|ARBA:ARBA00000696};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[protein]-dithiol + NADP(+) = [protein]-disulfide + H(+) +
CC NADPH; Xref=Rhea:RHEA:18753, Rhea:RHEA-COMP:10593, Rhea:RHEA-
CC COMP:10594, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058,
CC ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.8.1.8;
CC Evidence={ECO:0000256|ARBA:ARBA00001346};
CC -!- SIMILARITY: Belongs to the nucleoredoxin family.
CC {ECO:0000256|ARBA:ARBA00025782}.
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DR EMBL; BX284604; CAB02808.1; -; Genomic_DNA.
DR PIR; T19587; T19587.
DR RefSeq; NP_503101.1; NM_070700.4.
DR AlphaFoldDB; Q9XVR3; -.
DR SMR; Q9XVR3; -.
DR STRING; 6239.C30H6.8.2; -.
DR EPD; Q9XVR3; -.
DR PaxDb; 6239-C30H6-8; -.
DR PeptideAtlas; Q9XVR3; -.
DR EnsemblMetazoa; C30H6.8.1; C30H6.8.1; WBGene00007825.
DR UCSC; C30H6.8; c. elegans.
DR AGR; WB:WBGene00007825; -.
DR WormBase; C30H6.8; CE15652; WBGene00007825; -.
DR eggNOG; KOG2501; Eukaryota.
DR HOGENOM; CLU_116457_1_0_1; -.
DR InParanoid; Q9XVR3; -.
DR OMA; WCGSCKF; -.
DR OrthoDB; 2874159at2759; -.
DR PhylomeDB; Q9XVR3; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00007825; Expressed in germ line (C elegans) and 4 other cell types or tissues.
DR CDD; cd02964; TryX_like_family; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR012336; Thioredoxin-like_fold.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR017937; Thioredoxin_CS.
DR InterPro; IPR013766; Thioredoxin_domain.
DR PANTHER; PTHR13871; THIOREDOXIN; 1.
DR PANTHER; PTHR13871:SF18; THIOREDOXIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13905; Thioredoxin_8; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS00194; THIOREDOXIN_1; 1.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:Q9XVR3,
KW ECO:0007829|PeptideAtlas:Q9XVR3};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT DOMAIN 24..177
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
SQ SEQUENCE 178 AA; 20138 MW; E9C509554C1746ED CRC64;
MSPSLLGSSF LRSASGNFTK FASIRNAHFL SSVPMKKRGV DGNLPKDYFE NKTVVVYFSA
GWCGSCKFLT PKIKKFYNAV KESDAGKNLE IVWVSKDKEA AHQEEYYEKN LPDWPYIPFG
DENIQKLSEK YKAVVIPVLK LVNSNGDVVH DRVRADVEAG IKADPVKTME EWKKLLNQ
//
