ID Q9XVX5_CAEEL Unreviewed; 187 AA.
AC Q9XVX5;
DT 01-NOV-1999, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 2.
DT 27-MAR-2024, entry version 141.
DE RecName: Full=Vacuolar protein sorting-associated protein 29 {ECO:0000256|ARBA:ARBA00017767, ECO:0000256|RuleBase:RU362040};
DE AltName: Full=Vesicle protein sorting 29 {ECO:0000256|ARBA:ARBA00031913, ECO:0000256|RuleBase:RU362040};
GN Name=vps-29 {ECO:0000313|EMBL:CAA87426.2,
GN ECO:0000313|WormBase:ZK1128.8a};
GN ORFNames=CELE_ZK1128.8 {ECO:0000313|EMBL:CAA87426.2}, ZK1128.8
GN {ECO:0000313|WormBase:ZK1128.8a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAA87426.2, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAA87426.2, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAA87426.2,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Acts as component of the retromer cargo-selective complex
CC (CSC). The CSC is believed to be the core functional component of
CC retromer or respective retromer complex variants acting to prevent
CC missorting of selected transmembrane cargo proteins into the lysosomal
CC degradation pathway. {ECO:0000256|RuleBase:RU362040}.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}.
CC -!- SIMILARITY: Belongs to the VPS29 family.
CC {ECO:0000256|ARBA:ARBA00005945, ECO:0000256|RuleBase:RU362040}.
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DR EMBL; BX284603; CAA87426.2; -; Genomic_DNA.
DR PIR; T27697; T27697.
DR RefSeq; NP_001022987.1; NM_001027816.2.
DR AlphaFoldDB; Q9XVX5; -.
DR SMR; Q9XVX5; -.
DR EPD; Q9XVX5; -.
DR PeptideAtlas; Q9XVX5; -.
DR EnsemblMetazoa; ZK1128.8a.1; ZK1128.8a.1; WBGene00014234.
DR GeneID; 176424; -.
DR KEGG; cel:CELE_ZK1128.8; -.
DR UCSC; ZK1128.8b; c. elegans.
DR AGR; WB:WBGene00014234; -.
DR WormBase; ZK1128.8a; CE34140; WBGene00014234; vps-29.
DR GeneTree; ENSGT00390000012669; -.
DR HOGENOM; CLU_063749_0_1_1; -.
DR OrthoDB; 5481532at2759; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00014234; Expressed in germ line (C elegans) and 4 other cell types or tissues.
DR ExpressionAtlas; Q9XVX5; baseline and differential.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030904; C:retromer complex; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
DR CDD; cd07394; MPP_Vps29; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR InterPro; IPR024654; Calcineurin-like_PHP_lpxH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR000979; Phosphodiesterase_MJ0936/Vps29.
DR InterPro; IPR028661; Vps29.
DR NCBIfam; TIGR00040; yfcE; 1.
DR PANTHER; PTHR11124:SF12; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 29; 1.
DR PANTHER; PTHR11124; VACUOLAR SORTING PROTEIN VPS29; 1.
DR Pfam; PF12850; Metallophos_2; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE 1: Evidence at protein level;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|RuleBase:RU362040};
KW Proteomics identification {ECO:0007829|EPD:Q9XVX5,
KW ECO:0007829|PeptideAtlas:Q9XVX5};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362040}.
FT DOMAIN 1..159
FT /note="Calcineurin-like phosphoesterase"
FT /evidence="ECO:0000259|Pfam:PF12850"
SQ SEQUENCE 187 AA; 21065 MW; E258DF5450E23456 CRC64;
MLVLLIGDFN LPHRAANISP KFRKLLVPNK MQHVLCTGNL CSRETFDYLR TLSSDVHIVR
GEFDDETLKY PDTKVVTVGQ FRIGVCHGHQ IIPWGDQRML ELLARQLDVD ILVTGNTYEC
SAVEKNGRFF VDPGSATGSF SVTKTEPTTP SFALLDVQAD NVVTYLYRLI DDAVKVDRII
YKKSKTT
//
