ID Q9XW63_CAEEL Unreviewed; 2106 AA.
AC Q9XW63;
DT 01-NOV-1999, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2010, sequence version 2.
DT 24-JAN-2024, entry version 170.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN ORFNames=CELE_Y75B8A.24 {ECO:0000313|EMBL:CAA22108.2}, Y75B8A.24
GN {ECO:0000313|EMBL:CAA22108.2, ECO:0000313|WormBase:Y75B8A.24};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAA22108.2, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAA22108.2, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAA22108.2,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
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DR EMBL; BX284603; CAA22108.2; -; Genomic_DNA.
DR RefSeq; NP_499596.2; NM_067195.4.
DR AlphaFoldDB; Q9XW63; -.
DR SMR; Q9XW63; -.
DR IntAct; Q9XW63; 1.
DR MINT; Q9XW63; -.
DR STRING; 6239.Y75B8A.24.1; -.
DR EPD; Q9XW63; -.
DR PaxDb; 6239-Y75B8A-24; -.
DR PeptideAtlas; Q9XW63; -.
DR EnsemblMetazoa; Y75B8A.24.1; Y75B8A.24.1; WBGene00013557.
DR EnsemblMetazoa; Y75B8A.24.2; Y75B8A.24.2; WBGene00013557.
DR GeneID; 176653; -.
DR UCSC; Y75B8A.24; c. elegans.
DR AGR; WB:WBGene00013557; -.
DR WormBase; Y75B8A.24; CE44318; WBGene00013557; -.
DR eggNOG; KOG0902; Eukaryota.
DR GeneTree; ENSGT00550000074798; -.
DR HOGENOM; CLU_000893_2_0_1; -.
DR InParanoid; Q9XW63; -.
DR OMA; TIEVWQS; -.
DR OrthoDB; 147843at2759; -.
DR PhylomeDB; Q9XW63; -.
DR Reactome; R-CEL-1483248; Synthesis of PIPs at the ER membrane.
DR Reactome; R-CEL-1660514; Synthesis of PIPs at the Golgi membrane.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00013557; Expressed in germ line (C elegans) and 4 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004430; F:1-phosphatidylinositol 4-kinase activity; IBA:GO_Central.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IBA:GO_Central.
DR GO; GO:0048015; P:phosphatidylinositol-mediated signaling; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00871; PI4Ka; 1.
DR CDD; cd05167; PI4Kc_III_alpha; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR045495; PI4K_N.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR Pfam; PF19274; PI4K_N; 3.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 1: Evidence at protein level;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Proteomics identification {ECO:0007829|EPD:Q9XW63,
KW ECO:0007829|PeptideAtlas:Q9XW63};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1527..1713
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 1806..2090
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
SQ SEQUENCE 2106 AA; 236333 MW; FD1BA7581BFA5922 CRC64;
MRDIEDFVFT NKQCLAICIA QNENTKLSQI FNLLALDDKE EQFEAQPLSH NVRCSLIAIA
NYLLHSHGQH ADELVPMLLR ALIALPHMKW IDDGLLNKSD KIPIQEQFSF CFNTSLSDLA
AHLPRFRQQI VSAQADALAC AVSSIYDVLE DQESLEHNYS HVIKLMCYAL GLLRSIGRFS
ADYDTPLISL IFPLPVDETK KCKGAGGADI KHRISSDEFT FDTSCDASSS DPLLLTDSKS
SRLIRMYNKL GASFLLNNYT GGLKLTMSSE DLEKLFDSVQ RLMDSKFLES LDEISGEIFS
GGSGVKRNPY KSMSEITNLC CLTLLKDVLG PYSVKNSDKN QENCGNSLQE ASPSSPISEK
FAKEISIFSK TALSKLDAEL SSLQHSSESS LSTEVSRQKL NIQSATVCLQ LIAWAAIDDM
DADAICTEII VRLFANQTQK TIISQLPLYL KAISSMATLA EKFPAVATTA VIQNLQRFLL
EPAPMLTKLA SDSTLERGKS AGDVIQHSKS SNNLIDAITK RKLSLDALRN SAIKAICRAL
KSSIRMESDS VQQCLAGLST KLFVCSNANN FVVSLVCENA IQTLGGIGVG LVDSTAVEVP
EMVVQIYLQR FANPPSQLDV TMIRCLAEMW IAGARSIYEN VWKLFTQICI ESSNRVYSQG
NNESNDQRYT HVSLAVDVAM SRMAAGVANE DDKMTLLVRL LELFVQLGIE GRRVGEKVSK
STVKMSTSAG NLGVLMPKIA SLLRRMQPIS EPTTKLRSLF RDFWFYCTVL GFDVESSSLW
PEEWYNAVCE TATKTPVLIA TENLRSELID NAAIRSDSIS PQELQEMRNT VLAELSHQAE
AVPLINRFDF ANCTYLLSVH RMETMRLIHA NHVDAFSSFF KYIEDKTMRK DKSGLWTCML
AAAPRIFLEW CEKMMKRRDN DEPTEEALVW HAQFLLFKFN HHLREVRKVA DACLSQLVKA
FPYLLWNTKV LTTILRLLQE LEDNLQKDPT CREPQFTIEG FGGWTIQLQD SIEGRRSVVK
DFSMRVKQIL KEALRWAPAS THSNLLEYVS KFGSERDAAM QLAIDATSEG SGKSGSYLTS
LYKRSNYLGQ VKGMLATTLS GDIDQVTAEN QLIDRLEKDF QRACKSGKDM EMEQAVLLLT
ALFVSLRSLN ERILSLLVRT PLLNFTESTV SLCTMAWNWL LSARPEAHSL FLHEQARAFA
DSSRFGLGLF EKEVVGGSPL CQKLERPPPS ANFRPHREWI EFIGERCDVA SYSSREQLDV
LEMMFSQTLS AHIGTGHLHG STACSNPASL AGPSRKETIN QVTRGIEAVG VRFRLLSCVL
GMVQQDACLL RPTNVLIRQR VYSCAFHYFT IAPQGPTQPE ERLREDIRLL TRFFEHLKND
KHYMQKEALA KTDKNLVMSS TMSQMQTNFE KSLLISGTPV TATAAGTPNT SLMLPPSTNY
ANTLTLSSQK SMAATSASIR SGKSIETKLS IEEDRRIKTW MKQRNMLMLL VANEIERLSA
WLHPLALAQE DCALDSEEFL RGAFTQAKAT GGEKNIWREQ AQLAWDISPE LAIQLPSRFR
GSPELVKYVD VLVRGQPEPV AHIPEALPLF LGNGSTVFET SDMSHVLTWA RCSPVMALSL
LTPRIYPMHP ISMQYAVRVL RSYSADELLL YIPQIVQAVR YDTMGYISEL IIWLAGHSQL
LSHQLIWNMQ TNMFTDEESK VKDPVLFEAL NDIMQKILSQ LEGAARRFHE AEFKLFHQLT
AISGTIKPFP KGDARKKACL KALADVKIET ITYLPSNPEA VLLDLDYSSG TPMQSAAKAP
FLARFRVKRC GVRELEHIGL QAQSEHGGKT TEADLEELKK VQDSRVCWQA AIFKVGDDVR
QDMLALQLMQ LMKNVWAGLG LPVRVFPYRV VATSPGCGVI ECVPNSKSRD QLGRQTDFGL
YEYFKTQYGD ESSETFQEAR RNFVRSMAAY SVFSFLLQIK DRHNGNIMID LDGHIIHIDF
GFMFESSPGG NLGFEPDFKL SEEMVAIMGG KMEAAPFRQF ASLCVHAYLA VRPYHKSFVS
LVSLMLDTHL PCFRGKTINQ LRARFAPEMN EKDAAKYMYS VITNCFLNIR SKMYDQLQYF
QNEIPY
//