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Database: UniProt
Entry: Q9XW63_CAEEL
LinkDB: Q9XW63_CAEEL
Original site: Q9XW63_CAEEL 
ID   Q9XW63_CAEEL            Unreviewed;      2106 AA.
AC   Q9XW63;
DT   01-NOV-1999, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2010, sequence version 2.
DT   24-JAN-2024, entry version 170.
DE   RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE            EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN   ORFNames=CELE_Y75B8A.24 {ECO:0000313|EMBL:CAA22108.2}, Y75B8A.24
GN   {ECO:0000313|EMBL:CAA22108.2, ECO:0000313|WormBase:Y75B8A.24};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000313|EMBL:CAA22108.2, ECO:0000313|Proteomes:UP000001940};
RN   [1] {ECO:0000313|EMBL:CAA22108.2, ECO:0000313|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CAA22108.2,
RC   ECO:0000313|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RA   Sulson J.E., Waterston R.;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC       subfamily. {ECO:0000256|ARBA:ARBA00006209}.
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DR   EMBL; BX284603; CAA22108.2; -; Genomic_DNA.
DR   RefSeq; NP_499596.2; NM_067195.4.
DR   AlphaFoldDB; Q9XW63; -.
DR   SMR; Q9XW63; -.
DR   IntAct; Q9XW63; 1.
DR   MINT; Q9XW63; -.
DR   STRING; 6239.Y75B8A.24.1; -.
DR   EPD; Q9XW63; -.
DR   PaxDb; 6239-Y75B8A-24; -.
DR   PeptideAtlas; Q9XW63; -.
DR   EnsemblMetazoa; Y75B8A.24.1; Y75B8A.24.1; WBGene00013557.
DR   EnsemblMetazoa; Y75B8A.24.2; Y75B8A.24.2; WBGene00013557.
DR   GeneID; 176653; -.
DR   UCSC; Y75B8A.24; c. elegans.
DR   AGR; WB:WBGene00013557; -.
DR   WormBase; Y75B8A.24; CE44318; WBGene00013557; -.
DR   eggNOG; KOG0902; Eukaryota.
DR   GeneTree; ENSGT00550000074798; -.
DR   HOGENOM; CLU_000893_2_0_1; -.
DR   InParanoid; Q9XW63; -.
DR   OMA; TIEVWQS; -.
DR   OrthoDB; 147843at2759; -.
DR   PhylomeDB; Q9XW63; -.
DR   Reactome; R-CEL-1483248; Synthesis of PIPs at the ER membrane.
DR   Reactome; R-CEL-1660514; Synthesis of PIPs at the Golgi membrane.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00013557; Expressed in germ line (C elegans) and 4 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004430; F:1-phosphatidylinositol 4-kinase activity; IBA:GO_Central.
DR   GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR   GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IBA:GO_Central.
DR   GO; GO:0048015; P:phosphatidylinositol-mediated signaling; IBA:GO_Central.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd00871; PI4Ka; 1.
DR   CDD; cd05167; PI4Kc_III_alpha; 1.
DR   Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR   Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR   InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR   InterPro; IPR018936; PI3/4_kinase_CS.
DR   InterPro; IPR001263; PI3K_accessory_dom.
DR   InterPro; IPR042236; PI3K_accessory_sf.
DR   InterPro; IPR045495; PI4K_N.
DR   InterPro; IPR015433; PI_Kinase.
DR   PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR   PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR   Pfam; PF00454; PI3_PI4_kinase; 1.
DR   Pfam; PF00613; PI3Ka; 1.
DR   Pfam; PF19274; PI4K_N; 3.
DR   SMART; SM00145; PI3Ka; 1.
DR   SMART; SM00146; PI3Kc; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR   PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR   PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR   PROSITE; PS51545; PIK_HELICAL; 1.
PE   1: Evidence at protein level;
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Proteomics identification {ECO:0007829|EPD:Q9XW63,
KW   ECO:0007829|PeptideAtlas:Q9XW63};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          1527..1713
FT                   /note="PIK helical"
FT                   /evidence="ECO:0000259|PROSITE:PS51545"
FT   DOMAIN          1806..2090
FT                   /note="PI3K/PI4K catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50290"
SQ   SEQUENCE   2106 AA;  236333 MW;  FD1BA7581BFA5922 CRC64;
     MRDIEDFVFT NKQCLAICIA QNENTKLSQI FNLLALDDKE EQFEAQPLSH NVRCSLIAIA
     NYLLHSHGQH ADELVPMLLR ALIALPHMKW IDDGLLNKSD KIPIQEQFSF CFNTSLSDLA
     AHLPRFRQQI VSAQADALAC AVSSIYDVLE DQESLEHNYS HVIKLMCYAL GLLRSIGRFS
     ADYDTPLISL IFPLPVDETK KCKGAGGADI KHRISSDEFT FDTSCDASSS DPLLLTDSKS
     SRLIRMYNKL GASFLLNNYT GGLKLTMSSE DLEKLFDSVQ RLMDSKFLES LDEISGEIFS
     GGSGVKRNPY KSMSEITNLC CLTLLKDVLG PYSVKNSDKN QENCGNSLQE ASPSSPISEK
     FAKEISIFSK TALSKLDAEL SSLQHSSESS LSTEVSRQKL NIQSATVCLQ LIAWAAIDDM
     DADAICTEII VRLFANQTQK TIISQLPLYL KAISSMATLA EKFPAVATTA VIQNLQRFLL
     EPAPMLTKLA SDSTLERGKS AGDVIQHSKS SNNLIDAITK RKLSLDALRN SAIKAICRAL
     KSSIRMESDS VQQCLAGLST KLFVCSNANN FVVSLVCENA IQTLGGIGVG LVDSTAVEVP
     EMVVQIYLQR FANPPSQLDV TMIRCLAEMW IAGARSIYEN VWKLFTQICI ESSNRVYSQG
     NNESNDQRYT HVSLAVDVAM SRMAAGVANE DDKMTLLVRL LELFVQLGIE GRRVGEKVSK
     STVKMSTSAG NLGVLMPKIA SLLRRMQPIS EPTTKLRSLF RDFWFYCTVL GFDVESSSLW
     PEEWYNAVCE TATKTPVLIA TENLRSELID NAAIRSDSIS PQELQEMRNT VLAELSHQAE
     AVPLINRFDF ANCTYLLSVH RMETMRLIHA NHVDAFSSFF KYIEDKTMRK DKSGLWTCML
     AAAPRIFLEW CEKMMKRRDN DEPTEEALVW HAQFLLFKFN HHLREVRKVA DACLSQLVKA
     FPYLLWNTKV LTTILRLLQE LEDNLQKDPT CREPQFTIEG FGGWTIQLQD SIEGRRSVVK
     DFSMRVKQIL KEALRWAPAS THSNLLEYVS KFGSERDAAM QLAIDATSEG SGKSGSYLTS
     LYKRSNYLGQ VKGMLATTLS GDIDQVTAEN QLIDRLEKDF QRACKSGKDM EMEQAVLLLT
     ALFVSLRSLN ERILSLLVRT PLLNFTESTV SLCTMAWNWL LSARPEAHSL FLHEQARAFA
     DSSRFGLGLF EKEVVGGSPL CQKLERPPPS ANFRPHREWI EFIGERCDVA SYSSREQLDV
     LEMMFSQTLS AHIGTGHLHG STACSNPASL AGPSRKETIN QVTRGIEAVG VRFRLLSCVL
     GMVQQDACLL RPTNVLIRQR VYSCAFHYFT IAPQGPTQPE ERLREDIRLL TRFFEHLKND
     KHYMQKEALA KTDKNLVMSS TMSQMQTNFE KSLLISGTPV TATAAGTPNT SLMLPPSTNY
     ANTLTLSSQK SMAATSASIR SGKSIETKLS IEEDRRIKTW MKQRNMLMLL VANEIERLSA
     WLHPLALAQE DCALDSEEFL RGAFTQAKAT GGEKNIWREQ AQLAWDISPE LAIQLPSRFR
     GSPELVKYVD VLVRGQPEPV AHIPEALPLF LGNGSTVFET SDMSHVLTWA RCSPVMALSL
     LTPRIYPMHP ISMQYAVRVL RSYSADELLL YIPQIVQAVR YDTMGYISEL IIWLAGHSQL
     LSHQLIWNMQ TNMFTDEESK VKDPVLFEAL NDIMQKILSQ LEGAARRFHE AEFKLFHQLT
     AISGTIKPFP KGDARKKACL KALADVKIET ITYLPSNPEA VLLDLDYSSG TPMQSAAKAP
     FLARFRVKRC GVRELEHIGL QAQSEHGGKT TEADLEELKK VQDSRVCWQA AIFKVGDDVR
     QDMLALQLMQ LMKNVWAGLG LPVRVFPYRV VATSPGCGVI ECVPNSKSRD QLGRQTDFGL
     YEYFKTQYGD ESSETFQEAR RNFVRSMAAY SVFSFLLQIK DRHNGNIMID LDGHIIHIDF
     GFMFESSPGG NLGFEPDFKL SEEMVAIMGG KMEAAPFRQF ASLCVHAYLA VRPYHKSFVS
     LVSLMLDTHL PCFRGKTINQ LRARFAPEMN EKDAAKYMYS VITNCFLNIR SKMYDQLQYF
     QNEIPY
//
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