ID Q9XWJ9_CAEEL Unreviewed; 436 AA.
AC Q9XWJ9;
DT 01-NOV-1999, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1999, sequence version 1.
DT 27-MAR-2024, entry version 140.
DE SubName: Full=DRBM domain-containing protein {ECO:0000313|EMBL:CAA21662.1};
GN Name=dus-2 {ECO:0000313|EMBL:CAA21662.1,
GN ECO:0000313|WormBase:Y54E5A.6};
GN ORFNames=CELE_Y54E5A.6 {ECO:0000313|EMBL:CAA21662.1}, Y54E5A.6
GN {ECO:0000313|WormBase:Y54E5A.6};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAA21662.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAA21662.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAA21662.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210;
CC Evidence={ECO:0000256|ARBA:ARBA00001917};
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DR EMBL; BX284601; CAA21662.1; -; Genomic_DNA.
DR PIR; T27160; T27160.
DR RefSeq; NP_493554.1; NM_061153.1.
DR AlphaFoldDB; Q9XWJ9; -.
DR SMR; Q9XWJ9; -.
DR STRING; 6239.Y54E5A.6.1; -.
DR EPD; Q9XWJ9; -.
DR PaxDb; 6239-Y54E5A-6; -.
DR PeptideAtlas; Q9XWJ9; -.
DR EnsemblMetazoa; Y54E5A.6.1; Y54E5A.6.1; WBGene00013201.
DR EnsemblMetazoa; Y54E5A.6.2; Y54E5A.6.2; WBGene00013201.
DR GeneID; 173331; -.
DR KEGG; cel:CELE_Y54E5A.6; -.
DR UCSC; Y54E5A.6; c. elegans.
DR AGR; WB:WBGene00013201; -.
DR WormBase; Y54E5A.6; CE20317; WBGene00013201; dus-2.
DR eggNOG; KOG2334; Eukaryota.
DR GeneTree; ENSGT00550000075019; -.
DR HOGENOM; CLU_013299_3_0_1; -.
DR InParanoid; Q9XWJ9; -.
DR OMA; TMTKYVV; -.
DR OrthoDB; 276273at2759; -.
DR PhylomeDB; Q9XWJ9; -.
DR Reactome; R-CEL-9833482; PKR-mediated signaling.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00013201; Expressed in germ line (C elegans) and 4 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0000049; F:tRNA binding; IEA:InterPro.
DR GO; GO:0017150; F:tRNA dihydrouridine synthase activity; IBA:GO_Central.
DR GO; GO:0002943; P:tRNA dihydrouridine synthesis; IBA:GO_Central.
DR CDD; cd19871; DSRM_DUS2L; 1.
DR CDD; cd02801; DUS_like_FMN; 1.
DR Gene3D; 3.30.160.20; -; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR035587; DUS-like_FMN-bd.
DR InterPro; IPR044463; DUS2_DSRM.
DR InterPro; IPR018517; tRNA_hU_synthase_CS.
DR PANTHER; PTHR45936; TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE; 1.
DR PANTHER; PTHR45936:SF1; TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE; 1.
DR Pfam; PF00035; dsrm; 1.
DR Pfam; PF01207; Dus; 1.
DR SMART; SM00358; DSRM; 1.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
DR SUPFAM; SSF51395; FMN-linked oxidoreductases; 1.
DR PROSITE; PS01136; UPF0034; 1.
PE 1: Evidence at protein level;
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW FMN {ECO:0000256|ARBA:ARBA00022643};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Proteomics identification {ECO:0007829|EPD:Q9XWJ9,
KW ECO:0007829|PeptideAtlas:Q9XWJ9};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 360..424
FT /note="DRBM"
FT /evidence="ECO:0000259|SMART:SM00358"
SQ SEQUENCE 436 AA; 48998 MW; F6EA83B06A77C023 CRC64;
MSDLYRNKKI LAPMVRAGRT PLRLLCLKYG ADLCYTEEIV DKKLIEATRV VNEALGTIDY
RNGDDIILRL APEEKGRCIL QIGTNSGEKA AKIAQIVGDD VAGIDVNMGC PKPFSIHCGM
GAALLTQTEK IVDILTSLKS AAKVPVTCKI RVLDDPEDTL KLVQEIEKCR VSALGVHGRR
RDERQPDKCR IDEIRDVAQA VQSIPVISNG LSDEIEQYSD FEKYQLLTET SSTMIARKAL
STPSIFRREG CLDKYEDIRN FLELACQYDE SYTMTKYVVQ RILGADQEYD PRGKATVAAG
SVLQICKAFG MEDVYDKWRD ERKKKQSKKR ARVDDDGVYN IEVSFPLKRL KNSVGFSPTP
KMVLHDYCVE TKIPKATYEV VKRDDKRFVA TACIGDKKYR SGIGQPNLRM AEQVAALAAL
HGMNIRNLLV GNWEEE
//
