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Database: UniProt
Entry: Q9XXE6_CAEEL
LinkDB: Q9XXE6_CAEEL
Original site: Q9XXE6_CAEEL 
ID   Q9XXE6_CAEEL            Unreviewed;      1066 AA.
AC   Q9XXE6;
DT   01-NOV-1999, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1999, sequence version 1.
DT   24-JAN-2024, entry version 155.
DE   RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE            EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN   Name=oxi-1 {ECO:0000313|EMBL:CAA19508.1,
GN   ECO:0000313|WormBase:Y39A1C.2};
GN   ORFNames=CELE_Y39A1C.2 {ECO:0000313|EMBL:CAA19508.1}, Y39A1C.2
GN   {ECO:0000313|WormBase:Y39A1C.2};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000313|EMBL:CAA19508.1, ECO:0000313|Proteomes:UP000001940};
RN   [1] {ECO:0000313|EMBL:CAA19508.1, ECO:0000313|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CAA19508.1,
RC   ECO:0000313|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RA   Sulson J.E., Waterston R.;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
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DR   EMBL; BX284603; CAA19508.1; -; Genomic_DNA.
DR   PIR; T26753; T26753.
DR   RefSeq; NP_499392.1; NM_066991.4.
DR   AlphaFoldDB; Q9XXE6; -.
DR   SMR; Q9XXE6; -.
DR   STRING; 6239.Y39A1C.2.1; -.
DR   EPD; Q9XXE6; -.
DR   PaxDb; 6239-Y39A1C-2; -.
DR   PeptideAtlas; Q9XXE6; -.
DR   EnsemblMetazoa; Y39A1C.2.1; Y39A1C.2.1; WBGene00003898.
DR   GeneID; 176515; -.
DR   UCSC; Y39A1C.2; c. elegans.
DR   AGR; WB:WBGene00003898; -.
DR   WormBase; Y39A1C.2; CE19147; WBGene00003898; oxi-1.
DR   eggNOG; KOG4427; Eukaryota.
DR   GeneTree; ENSGT00940000156548; -.
DR   HOGENOM; CLU_002173_2_0_1; -.
DR   InParanoid; Q9XXE6; -.
DR   OMA; HRMAHHR; -.
DR   OrthoDB; 1386at2759; -.
DR   PhylomeDB; Q9XXE6; -.
DR   Reactome; R-CEL-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00003898; Expressed in germ line (C elegans) and 4 other cell types or tissues.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR   GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   CDD; cd00078; HECTc; 1.
DR   Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR   InterPro; IPR044611; E3A/B/C-like.
DR   InterPro; IPR000569; HECT_dom.
DR   InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR   PANTHER; PTHR45700:SF3; UBIQUITIN-PROTEIN LIGASE E3B; 1.
DR   PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR   Pfam; PF00632; HECT; 1.
DR   SMART; SM00119; HECTc; 1.
DR   SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR   PROSITE; PS50237; HECT; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:Q9XXE6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CAA19508.1};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW   ECO:0000256|PROSITE-ProRule:PRU00104}.
FT   DOMAIN          704..1066
FT                   /note="HECT"
FT                   /evidence="ECO:0000259|PROSITE:PS50237"
FT   COILED          1..28
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   ACT_SITE        1034
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ   SEQUENCE   1066 AA;  120882 MW;  83B42316F95C8BA4 CRC64;
     MDNILRTLQK NAREREEEET QRRRIELAHK LEPYLIGYLT RKKFHGKIKT FRPTFFNDFN
     DLEKSNKTLL PVAQMLVKVP RVIENSRENK DIQMLCNICR HLIISIDSPS KEISFVAAFL
     NKDTIKEATS LITSIFSQIP QILCSINGER AAELKQWQCL IHFVIVFSSS SNWLLVRNAP
     QVQTVLNGLC VKMMSLFYEP KGYEQMATSL FVSVNGHKPL INVETVNAQF SILCKPLKTE
     NPELFSIFVL KVLTCPALLV HLNAQHVELL KTTKIFEKTL HWLRANAEEI ETGMDVRLLI
     NLLANLVHFA YINDKTLESK LYEWTWAVGV SLSRCTELTV KHGGTKTSLH YWHPVFGHYL
     LPIDKRTEGA LRNVLFQLKM LWSSRVVRCL FGNIMENTKT ASFSVTDGQK NSKDISAAFS
     KLWRKLGGST DSASSSSKSE SEPPPTLIAI VCQVYMTALN TMVHMKGEII SGLCRDDQLL
     KQLWTYLREW GEKAGGTSGS IFNSSNAEQW GPVSASLQSL KRPSSPHTAT LRLFVDCAAA
     IISILDEEEI FEKETPFSNK ELESICKYVN IFCFRSIWSG AVDETSANTT GLFHSMHSLL
     TVLYERDSRR SFAANDSKFW LISEVKPSSL TIEYEKKSGK GVLMMRKMAH LVPIKDRMLL
     FRRQVQDDKN RVATSLNDPQ MQTWITVQRN RIIEDGFNHL SKLTIPALKS TIRVKFVNEQ
     GLDEAGIDQD GVFKEFLELT LKKVFDPQLN LFSTTSTGVL YPSPTSSLHD DHLALFTFVG
     RMLGKAVYEG IVVDVQLAPV LLAAVLGSHR LCAFDELSQL DPELYRSLTF VKRYEGEMAD
     LSLTFSVDED FMGKISTVDL VPSGRTISVT NENKIDYVHR MAHHRVFRRT QEQCKAFVTG
     MQSILQPTWL SLFAPNDLQC LISGVNSDID LADLKRNVQY FGGFHGNHRL IKWLWDILEN
     KFTSEERKLF LKFVTSCSRP PVLGFSYLEP PFSIRCVEVS DDQDQGDTLG SVVRGFLALR
     KGTAATRLPT ASTCFNLLKL PNYNKKSLLL EKLRYAIHAG TGFELS
//
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