ID Q9XXE6_CAEEL Unreviewed; 1066 AA.
AC Q9XXE6;
DT 01-NOV-1999, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1999, sequence version 1.
DT 24-JAN-2024, entry version 155.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN Name=oxi-1 {ECO:0000313|EMBL:CAA19508.1,
GN ECO:0000313|WormBase:Y39A1C.2};
GN ORFNames=CELE_Y39A1C.2 {ECO:0000313|EMBL:CAA19508.1}, Y39A1C.2
GN {ECO:0000313|WormBase:Y39A1C.2};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAA19508.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAA19508.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAA19508.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
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DR EMBL; BX284603; CAA19508.1; -; Genomic_DNA.
DR PIR; T26753; T26753.
DR RefSeq; NP_499392.1; NM_066991.4.
DR AlphaFoldDB; Q9XXE6; -.
DR SMR; Q9XXE6; -.
DR STRING; 6239.Y39A1C.2.1; -.
DR EPD; Q9XXE6; -.
DR PaxDb; 6239-Y39A1C-2; -.
DR PeptideAtlas; Q9XXE6; -.
DR EnsemblMetazoa; Y39A1C.2.1; Y39A1C.2.1; WBGene00003898.
DR GeneID; 176515; -.
DR UCSC; Y39A1C.2; c. elegans.
DR AGR; WB:WBGene00003898; -.
DR WormBase; Y39A1C.2; CE19147; WBGene00003898; oxi-1.
DR eggNOG; KOG4427; Eukaryota.
DR GeneTree; ENSGT00940000156548; -.
DR HOGENOM; CLU_002173_2_0_1; -.
DR InParanoid; Q9XXE6; -.
DR OMA; HRMAHHR; -.
DR OrthoDB; 1386at2759; -.
DR PhylomeDB; Q9XXE6; -.
DR Reactome; R-CEL-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00003898; Expressed in germ line (C elegans) and 4 other cell types or tissues.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR044611; E3A/B/C-like.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR PANTHER; PTHR45700:SF3; UBIQUITIN-PROTEIN LIGASE E3B; 1.
DR PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q9XXE6};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CAA19508.1};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 704..1066
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT COILED 1..28
FT /evidence="ECO:0000256|SAM:Coils"
FT ACT_SITE 1034
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 1066 AA; 120882 MW; 83B42316F95C8BA4 CRC64;
MDNILRTLQK NAREREEEET QRRRIELAHK LEPYLIGYLT RKKFHGKIKT FRPTFFNDFN
DLEKSNKTLL PVAQMLVKVP RVIENSRENK DIQMLCNICR HLIISIDSPS KEISFVAAFL
NKDTIKEATS LITSIFSQIP QILCSINGER AAELKQWQCL IHFVIVFSSS SNWLLVRNAP
QVQTVLNGLC VKMMSLFYEP KGYEQMATSL FVSVNGHKPL INVETVNAQF SILCKPLKTE
NPELFSIFVL KVLTCPALLV HLNAQHVELL KTTKIFEKTL HWLRANAEEI ETGMDVRLLI
NLLANLVHFA YINDKTLESK LYEWTWAVGV SLSRCTELTV KHGGTKTSLH YWHPVFGHYL
LPIDKRTEGA LRNVLFQLKM LWSSRVVRCL FGNIMENTKT ASFSVTDGQK NSKDISAAFS
KLWRKLGGST DSASSSSKSE SEPPPTLIAI VCQVYMTALN TMVHMKGEII SGLCRDDQLL
KQLWTYLREW GEKAGGTSGS IFNSSNAEQW GPVSASLQSL KRPSSPHTAT LRLFVDCAAA
IISILDEEEI FEKETPFSNK ELESICKYVN IFCFRSIWSG AVDETSANTT GLFHSMHSLL
TVLYERDSRR SFAANDSKFW LISEVKPSSL TIEYEKKSGK GVLMMRKMAH LVPIKDRMLL
FRRQVQDDKN RVATSLNDPQ MQTWITVQRN RIIEDGFNHL SKLTIPALKS TIRVKFVNEQ
GLDEAGIDQD GVFKEFLELT LKKVFDPQLN LFSTTSTGVL YPSPTSSLHD DHLALFTFVG
RMLGKAVYEG IVVDVQLAPV LLAAVLGSHR LCAFDELSQL DPELYRSLTF VKRYEGEMAD
LSLTFSVDED FMGKISTVDL VPSGRTISVT NENKIDYVHR MAHHRVFRRT QEQCKAFVTG
MQSILQPTWL SLFAPNDLQC LISGVNSDID LADLKRNVQY FGGFHGNHRL IKWLWDILEN
KFTSEERKLF LKFVTSCSRP PVLGFSYLEP PFSIRCVEVS DDQDQGDTLG SVVRGFLALR
KGTAATRLPT ASTCFNLLKL PNYNKKSLLL EKLRYAIHAG TGFELS
//