ID Q9XXF6_CAEEL Unreviewed; 691 AA.
AC Q9XXF6;
DT 01-NOV-1999, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 2.
DT 24-JAN-2024, entry version 165.
DE SubName: Full=Potassium channel domain-containing protein {ECO:0000313|EMBL:CAA19494.2};
GN Name=egl-23 {ECO:0000313|EMBL:CAA19494.2,
GN ECO:0000313|WormBase:Y37A1B.11a};
GN ORFNames=CELE_Y37A1B.11 {ECO:0000313|EMBL:CAA19494.2}, Y37A1B.11
GN {ECO:0000313|WormBase:Y37A1B.11a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAA19494.2, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAA19494.2, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAA19494.2,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC 1.A.1.8) family. {ECO:0000256|ARBA:ARBA00006666,
CC ECO:0000256|RuleBase:RU003857}.
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DR EMBL; BX284604; CAA19494.2; -; Genomic_DNA.
DR PIR; T26616; T26616.
DR RefSeq; NP_001255776.1; NM_001268847.1.
DR AlphaFoldDB; Q9XXF6; -.
DR EPD; Q9XXF6; -.
DR EnsemblMetazoa; Y37A1B.11a.1; Y37A1B.11a.1; WBGene00001190.
DR GeneID; 178358; -.
DR UCSC; Y37A1B.11; c. elegans.
DR AGR; WB:WBGene00001190; -.
DR WormBase; Y37A1B.11a; CE32244; WBGene00001190; egl-23.
DR GeneTree; ENSGT00700000104522; -.
DR HOGENOM; CLU_028432_0_0_1; -.
DR OrthoDB; 2882865at2759; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00001190; Expressed in larva and 2 other cell types or tissues.
DR ExpressionAtlas; Q9XXF6; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015271; F:outward rectifier potassium channel activity; IBA:GO_Central.
DR GO; GO:0022841; F:potassium ion leak channel activity; IBA:GO_Central.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0030322; P:stabilization of membrane potential; IBA:GO_Central.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR11003; POTASSIUM CHANNEL, SUBFAMILY K; 1.
DR PANTHER; PTHR11003:SF317; PROTEIN CBR-EGL-23; 1.
DR Pfam; PF07885; Ion_trans_2; 2.
DR PRINTS; PR01333; 2POREKCHANEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 1: Evidence at protein level;
KW Ion channel {ECO:0000256|RuleBase:RU003857, ECO:0000313|EMBL:CAA19494.2};
KW Ion transport {ECO:0000256|RuleBase:RU003857};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|EPD:Q9XXF6};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003857};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003857}.
FT TRANSMEM 21..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 185..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 215..233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 307..327
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 334..354
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..386
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 179..240
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 313..387
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT REGION 71..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 477..598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 610..691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 480..508
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..557
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..582
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..691
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 691 AA; 77123 MW; 719252E46564B283 CRC64;
MKLTLKKSVF SRDKHILQKA TPLFVHFLMI VSVGAYAIFG ALVMRSLESR TVTSIEKKTD
VHRRHVNLTN FQHPPTPITL EQRHRRRRRH NETALEDHLS EKLSREKRAA AHIMRSRKCV
ISVIKKMSSM ECSFDTLDEK LVKALDECYH VAVEHNTHVN HVLFTNSKEE VESVGEEAEE
DVSEWSFMDS LLFAFTVITT IGYGNVAPRT FGGRLFVIGY GLIGIPFTLL AIADLGKFIS
EMMVEAKSFC RKTWKKLKKA WNPNFIRAKD LSNTDIEEKI LDNEKIENEP ETSEVSEEED
DLTETEATSL FILFLVYIAF GGFMLAAYEP DMDFFKAVYF NFVTLTSIGL GDIVPRSETY
MLITIVYIAI GLALTTIAIE IAADALKKLH YFGRKIENVG NVAIWFGGKK ITMKALVKNL
GDQFNLPTTV VKNLNLDHFV DQAIKVEEGE IETLRPPPYE PPSDRFEAEF ADEPECEWIR
DPTPTPPPSP QPVYRLPSPK PVTPEPLPSP TITDVSLAIA TPSPEESDDD QELILPSPEP
SPVREPTPPP PPREPTPREP TPEPEPVREP TPPPPPPAKP RPLTAAEIAA QKRKAYSEEA
WRRYQEYQKQ WKKFRQTQKT PAPSGASTSG ASTSKPSGTS PESGAGVCTG PSTRSQSITS
VASGKTSRSA TPESKKSSHL SGSSRRESGG K
//
