ID GST1_SCHPO Reviewed; 229 AA.
AC Q9Y7Q2;
DT 06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 27-MAR-2024, entry version 138.
DE RecName: Full=Glutathione S-transferase 1;
DE EC=2.5.1.18;
DE AltName: Full=GST-I;
GN Name=gst1; ORFNames=SPCC191.09c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11513961; DOI=10.1016/s0167-4781(01)00265-2;
RA Kim H.-G., Park K.-N., Cho Y.-W., Park E.-H., Fuchs J.A., Lim C.-J.;
RT "Characterization and regulation of glutathione S-transferase gene from
RT Schizosaccharomyces pombe.";
RL Biochim. Biophys. Acta 1520:179-185(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Involved in the oxidative stress response and detoxification.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glutathione + RX = a halide anion + an S-substituted
CC glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925,
CC ChEBI:CHEBI:90779; EC=2.5.1.18;
CC -!- INDUCTION: By heavy metals such as cadmium.
CC -!- SIMILARITY: Belongs to the GST superfamily. {ECO:0000305}.
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DR EMBL; AF213355; AAF21054.1; -; Genomic_DNA.
DR EMBL; CU329672; CAB41055.1; -; Genomic_DNA.
DR PIR; T41222; T41222.
DR RefSeq; NP_588298.1; NM_001023288.2.
DR AlphaFoldDB; Q9Y7Q2; -.
DR SMR; Q9Y7Q2; -.
DR BioGRID; 275279; 33.
DR STRING; 284812.Q9Y7Q2; -.
DR iPTMnet; Q9Y7Q2; -.
DR MaxQB; Q9Y7Q2; -.
DR PaxDb; 4896-SPCC191-09c-1; -.
DR EnsemblFungi; SPCC191.09c.1; SPCC191.09c.1:pep; SPCC191.09c.
DR GeneID; 2538694; -.
DR KEGG; spo:SPCC191.09c; -.
DR PomBase; SPCC191.09c; gst1.
DR VEuPathDB; FungiDB:SPCC191.09c; -.
DR eggNOG; KOG0867; Eukaryota.
DR HOGENOM; CLU_011226_14_2_1; -.
DR InParanoid; Q9Y7Q2; -.
DR OMA; PYGPNPW; -.
DR PhylomeDB; Q9Y7Q2; -.
DR PRO; PR:Q9Y7Q2; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0005737; C:cytoplasm; IDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; IDA:PomBase.
DR GO; GO:0004364; F:glutathione transferase activity; IMP:PomBase.
DR GO; GO:1990748; P:cellular detoxification; NAS:PomBase.
DR CDD; cd10293; GST_C_Ure2p; 1.
DR CDD; cd03048; GST_N_Ure2p_like; 1.
DR Gene3D; 1.20.1050.130; -; 1.
DR InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR040079; Glutathione_S-Trfase.
DR InterPro; IPR004045; Glutathione_S-Trfase_N.
DR InterPro; IPR004046; GST_C.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR44051; GLUTATHIONE S-TRANSFERASE-RELATED; 1.
DR PANTHER; PTHR44051:SF3; TRANSCRIPTIONAL REGULATOR URE2; 1.
DR Pfam; PF00043; GST_C; 1.
DR Pfam; PF02798; GST_N; 1.
DR SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR SFLD; SFLDG01151; Main.2:_Nu-like; 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS50405; GST_CTER; 1.
DR PROSITE; PS50404; GST_NTER; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Transferase.
FT CHAIN 1..229
FT /note="Glutathione S-transferase 1"
FT /id="PRO_0000185984"
FT DOMAIN 2..86
FT /note="GST N-terminal"
FT DOMAIN 93..229
FT /note="GST C-terminal"
SQ SEQUENCE 229 AA; 27017 MW; 9A302350C5FD3CD7 CRC64;
MAQFTLWSHA HGPNPWKVVQ ALKELDLTYE TRYVNFSKNE QKSPEHLALN PNGRVPTLID
HHNNDYTIWE SDAILIYLAD KYDTERKISL PRDHPEYYKV IQYLFFQASG QGIIWGQAGW
FSVYHQELVI SAITRYRNEI KRVLGVLEDI LKDRDYLVAN RFTIADLSFI SWNNFLEIIF
AEGKFSIEEE VPQLDFEKEF PRTYSWHQRL LARPASKATF EERSKALDN
//
