GenomeNet

Database: UniProt
Entry: Q9YAW4
LinkDB: Q9YAW4
Original site: Q9YAW4 
ID   GYAR_AERPE              Reviewed;         335 AA.
AC   Q9YAW4;
DT   10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2004, sequence version 2.
DT   16-JAN-2019, entry version 102.
DE   RecName: Full=Glyoxylate reductase {ECO:0000255|HAMAP-Rule:MF_00776};
DE            EC=1.1.1.26 {ECO:0000255|HAMAP-Rule:MF_00776};
GN   Name=gyaR {ECO:0000255|HAMAP-Rule:MF_00776};
GN   OrderedLocusNames=APE_1831.1;
OS   Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC
OS   100138 / K1).
OC   Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales;
OC   Desulfurococcaceae; Aeropyrum.
OX   NCBI_TaxID=272557;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1;
RX   PubMed=10382966; DOI=10.1093/dnares/6.2.83;
RA   Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y.,
RA   Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H.,
RA   Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H.,
RA   Takamiya M., Masuda S., Funahashi T., Tanaka T., Kudoh Y.,
RA   Yamazaki J., Kushida N., Oguchi A., Aoki K., Kubota K., Nakamura Y.,
RA   Nomura N., Sako Y., Kikuchi H.;
RT   "Complete genome sequence of an aerobic hyper-thermophilic
RT   crenarchaeon, Aeropyrum pernix K1.";
RL   DNA Res. 6:83-101(1999).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glycolate + NAD(+) = glyoxylate + H(+) + NADH;
CC         Xref=Rhea:RHEA:18229, ChEBI:CHEBI:15378, ChEBI:CHEBI:29805,
CC         ChEBI:CHEBI:36655, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945;
CC         EC=1.1.1.26; Evidence={ECO:0000255|HAMAP-Rule:MF_00776};
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00776}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00776}.
CC   -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC       dehydrogenase family. GyaR subfamily. {ECO:0000255|HAMAP-
CC       Rule:MF_00776}.
DR   EMBL; BA000002; BAA80834.2; -; Genomic_DNA.
DR   PIR; E72568; E72568.
DR   ProteinModelPortal; Q9YAW4; -.
DR   SMR; Q9YAW4; -.
DR   STRING; 272557.APE_1831.1; -.
DR   PRIDE; Q9YAW4; -.
DR   EnsemblBacteria; BAA80834; BAA80834; APE_1831.1.
DR   KEGG; ape:APE_1831.1; -.
DR   PATRIC; fig|272557.25.peg.1228; -.
DR   eggNOG; arCOG01755; Archaea.
DR   eggNOG; COG1052; LUCA.
DR   HOGENOM; HOG000136700; -.
DR   KO; K00015; -.
DR   OMA; KWIAHNG; -.
DR   Proteomes; UP000002518; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0047964; F:glyoxylate reductase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   HAMAP; MF_00776; GyaR; 1.
DR   InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR   InterPro; IPR029753; D-isomer_DH_CS.
DR   InterPro; IPR029752; D-isomer_DH_CS1.
DR   InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR   InterPro; IPR023519; Glyoxylate_reductase_GyaR.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00389; 2-Hacid_dh; 1.
DR   Pfam; PF02826; 2-Hacid_dh_C; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
DR   PROSITE; PS00670; D_2_HYDROXYACID_DH_2; 1.
DR   PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; NAD; Oxidoreductase; Reference proteome.
FT   CHAIN         1    335       Glyoxylate reductase.
FT                                /FTId=PRO_0000075946.
FT   NP_BIND     159    162       NADP. {ECO:0000255|HAMAP-Rule:MF_00776}.
FT   NP_BIND     181    183       NADP. {ECO:0000255|HAMAP-Rule:MF_00776}.
FT   NP_BIND     240    242       NADP. {ECO:0000255|HAMAP-Rule:MF_00776}.
FT   NP_BIND     290    292       NADP. {ECO:0000255|HAMAP-Rule:MF_00776}.
FT   ACT_SITE    242    242       {ECO:0000255|HAMAP-Rule:MF_00776}.
FT   ACT_SITE    271    271       {ECO:0000255|HAMAP-Rule:MF_00776}.
FT   ACT_SITE    290    290       Proton donor. {ECO:0000255|HAMAP-
FT                                Rule:MF_00776}.
SQ   SEQUENCE   335 AA;  37757 MW;  0CD5EE38E1AA6163 CRC64;
     MKRPRVFVTR EVFPEALELL SKYYDVEVWD KYQPPPYETL LSKAREADAL YTLLTDRIDC
     DLLSQAPRLR IVAQMAVGFD NIDVECATRL GIYVTNTPGV LTEATAEFTW ALILAAARRV
     VEADHFVRWG EWWRLRTGWH PMMMLGVELR GKTLGILGMG RIGSRVAEIG KAFGMRIIYH
     SRSRKREIEK ELGAEYRSLE DLLRESDILS IHLPLTDETR HLIGESELKL MKKTAILVNT
     GRGAIVDTGA LVKALREGWI AAAALDVFEE EPLNPNHPLT AFKNVVLAPH AASATRETRL
     RMAMMAAENL VAFAQGKVPP NLVNREVVKV RQPGF
//
DBGET integrated database retrieval system