ID Q9YHC4_XENLA Unreviewed; 471 AA.
AC Q9YHC4;
DT 01-MAY-1999, integrated into UniProtKB/TrEMBL.
DT 01-MAY-1999, sequence version 1.
DT 27-MAR-2024, entry version 137.
DE SubName: Full=Chromobox 2 L homeolog {ECO:0000313|RefSeq:NP_001081900.1};
DE SubName: Full=Pc1 protein {ECO:0000313|EMBL:AAH72868.1};
DE SubName: Full=Polycomb homolog Pc1 {ECO:0000313|EMBL:AAC72981.1};
GN Name=cbx2.L {ECO:0000313|RefSeq:NP_001081900.1,
GN ECO:0000313|Xenbase:XB-GENE-17343858};
GN Synonyms=cbx2 {ECO:0000313|RefSeq:NP_001081900.1,
GN ECO:0000313|Xenbase:XB-GENE-17343858}, cdca6
GN {ECO:0000313|RefSeq:NP_001081900.1}, m33
GN {ECO:0000313|RefSeq:NP_001081900.1}, Pc1
GN {ECO:0000313|EMBL:AAC72981.1}, pc1
GN {ECO:0000313|RefSeq:NP_001081900.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAC72981.1};
RN [1] {ECO:0000313|EMBL:AAC72981.1, ECO:0000313|RefSeq:NP_001081900.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=10330136;
RA Strouboulis J., Damjanovski S., Vermaak D., Meric F., Wolffe A.P.;
RT "Transcriptional repression by XPc1, a new Polycomb homolog in Xenopus
RT laevis embryos, is independent of histone deacetylase.";
RL Mol. Cell. Biol. 19:3958-3968(1999).
RN [2] {ECO:0000313|RefSeq:NP_001081900.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [3] {ECO:0000313|EMBL:AAH72868.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary {ECO:0000313|EMBL:AAH72868.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|RefSeq:NP_001081900.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (APR-2022) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF101438; AAC72981.1; -; mRNA.
DR EMBL; BC072868; AAH72868.1; -; mRNA.
DR RefSeq; NP_001081900.1; NM_001088431.2.
DR STRING; 8355.Q9YHC4; -.
DR PaxDb; 8355-Q9YHC4; -.
DR DNASU; 398110; -.
DR GeneID; 398110; -.
DR KEGG; xla:398110; -.
DR AGR; Xenbase:XB-GENE-17343858; -.
DR CTD; 398110; -.
DR Xenbase; XB-GENE-17343858; cbx2.L.
DR OMA; AHTKEAC; -.
DR OrthoDB; 75895at2759; -.
DR Proteomes; UP000186698; Chromosome 9_10L.
DR GO; GO:0035102; C:PRC1 complex; IEA:InterPro.
DR CDD; cd18647; CD_Cbx2; 1.
DR Gene3D; 2.40.50.40; -; 1.
DR InterPro; IPR042796; CBX2.
DR InterPro; IPR033773; CBX7_C.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR023779; Chromodomain_CS.
DR PANTHER; PTHR46860; CHROMOBOX PROTEIN HOMOLOG 2; 1.
DR PANTHER; PTHR46860:SF1; CHROMOBOX PROTEIN HOMOLOG 2; 1.
DR Pfam; PF17218; CBX7_C; 1.
DR Pfam; PF00385; Chromo; 1.
DR SMART; SM00298; CHROMO; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 1.
DR PROSITE; PS00598; CHROMO_1; 1.
DR PROSITE; PS50013; CHROMO_2; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000186698}.
FT DOMAIN 12..70
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT REGION 61..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..135
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 144..172
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..274
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..362
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 471 AA; 51289 MW; 5AECD7559A64C771 CRC64;
MEELSAVGEQ VFAAECILSK RLRKGTAEYL VKWRGWSSKH NSWEPEENIL DPRLLVAFQK
REQEKELRNR KRGKRPRGRP RKNVETDIPL KAKSSSSSSS SSSSSSSSSS SSSSSDDSDA
ETQQRNPRPR DSHPVPQKKA PAVLARTELK EPVRKKRGRK PLPPEQKLPR RAKGAKPGPK
GSMNKLQPGH NIQGFQALKT HSKDMHASSN NRPGGLSAEL LSSIAKNSPT QPNGSSPRSL
SWQSSIVHYM NRINQNSSQP GRKPASSTFN AKRSCLDAKS LFKPRSEAEI SPAMPKTSKL
HENEEQTHSH TVQPAPTVAA GSNENPSQNA PVQTKTQGMR AVVVTSPTSQ NTQKSNGSHA
VGVATSCKGD KIGKKTGVVT EPTAHPATER AQPTEGQRDV ADLSTGDDSS LDSDHDSSLS
SQDMAVQASQ DWKPARSLLE HVFVTDVTAN LITVTVKESP TSVGFFNMRH F
//
