ID Q9Z4Y8_STRCO Unreviewed; 388 AA.
AC Q9Z4Y8;
DT 01-MAY-1999, integrated into UniProtKB/TrEMBL.
DT 01-MAY-1999, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE RecName: Full=inositol-3-phosphate synthase {ECO:0000256|ARBA:ARBA00012125};
DE EC=5.5.1.4 {ECO:0000256|ARBA:ARBA00012125};
GN OrderedLocusNames=SCO3243 {ECO:0000313|EMBL:CAB38887.1};
GN ORFNames=SCE29.12c {ECO:0000313|EMBL:CAB38887.1};
OS Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.
OX NCBI_TaxID=100226 {ECO:0000313|EMBL:CAB38887.1, ECO:0000313|Proteomes:UP000001973};
RN [1] {ECO:0000313|EMBL:CAB38887.1, ECO:0000313|Proteomes:UP000001973}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-471 / A3(2) / M145
RC {ECO:0000313|Proteomes:UP000001973};
RX PubMed=12000953; DOI=10.1038/417141a;
RA Bentley S.D., Chater K.F., Cerdeno-Tarraga A.M., Challis G.L.,
RA Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.H.,
RA Kieser T., Larke L., Murphy L., Oliver K., O'Neil S., Rabbinowitsch E.,
RA Rajandream M.A., Rutherford K., Rutter S., Seeger K., Saunders D.,
RA Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA Woodward J., Barrell B.G., Parkhill J., Hopwood D.A.;
RT "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT A3(2).";
RL Nature 417:141-147(2002).
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- PATHWAY: Polyol metabolism; myo-inositol biosynthesis; myo-inositol
CC from D-glucose 6-phosphate: step 1/2. {ECO:0000256|ARBA:ARBA00005117}.
CC -!- SIMILARITY: Belongs to the myo-inositol 1-phosphate synthase family.
CC {ECO:0000256|ARBA:ARBA00010813}.
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DR EMBL; AL939115; CAB38887.1; -; Genomic_DNA.
DR PIR; T36191; T36191.
DR RefSeq; NP_627455.1; NC_003888.3.
DR RefSeq; WP_011028853.1; NZ_VNID01000025.1.
DR AlphaFoldDB; Q9Z4Y8; -.
DR STRING; 100226.gene:17760861; -.
DR PaxDb; 100226-SCO3243; -.
DR PATRIC; fig|100226.15.peg.3307; -.
DR eggNOG; COG1260; Bacteria.
DR HOGENOM; CLU_021486_0_0_11; -.
DR InParanoid; Q9Z4Y8; -.
DR OrthoDB; 729130at2; -.
DR PhylomeDB; Q9Z4Y8; -.
DR Proteomes; UP000001973; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0004512; F:inositol-3-phosphate synthase activity; IBA:GO_Central.
DR GO; GO:0006021; P:inositol biosynthetic process; IBA:GO_Central.
DR GO; GO:0008654; P:phospholipid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002587; Myo-inos-1-P_Synthase.
DR InterPro; IPR013021; Myo-inos-1-P_Synthase_GAPDH.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR11510:SF5; INOSITOL-3-PHOSPHATE SYNTHASE 1; 1.
DR PANTHER; PTHR11510; MYO-INOSITOL-1 PHOSPHATE SYNTHASE; 1.
DR Pfam; PF01658; Inos-1-P_synth; 1.
DR Pfam; PF07994; NAD_binding_5; 1.
DR PIRSF; PIRSF015578; Myoinos-ppht_syn; 1.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000001973}.
FT DOMAIN 222..326
FT /note="Myo-inositol-1-phosphate synthase GAPDH-like"
FT /evidence="ECO:0000259|Pfam:PF01658"
SQ SEQUENCE 388 AA; 39858 MW; 7BF54964273FAA68 CRC64;
MRTGIWLVGA RGSVATTTVV GAAALRAGLV PATGCVSALE AFDGVPLPGF DELVFGGHDV
VGTGLVKRAE QLAEAGVVPR GLPGVLTAEL DAADAEIRPA PPGTEEGGDG TPDQASAAGA
IVADLTGFRE RLGLDRVVVV NVSSTQPPAV PHPAHASAAA LREALARGER PLPVSSLYAY
AALRAGCAFV DFTPSTGARL PALDELAREQ GLPYAGSDGK TGETLVKSVL APMFARRALR
VRSWSGTNLL GGGDGATLAD PERVVSKNAS KGLVLEAELG HAVEGGVHIH HVPDLGEWKT
AWDHVTFEGF LGARMTLQFT WQGCDSSLAA PLVLDLARFM ALAHRAGVAG PVPELGFFFK
DPVGSAEHDL AAQYASLAAW ARSVGAPA
//
