ID Q9Z830_CHLPN Unreviewed; 223 AA.
AC Q9Z830; Q7AIN1; Q7DEX5;
DT 01-MAY-1999, integrated into UniProtKB/TrEMBL.
DT 01-MAY-1999, sequence version 1.
DT 24-JAN-2024, entry version 126.
DE RecName: Full=Uroporphyrinogen-III synthase {ECO:0000256|ARBA:ARBA00040167, ECO:0000256|RuleBase:RU366031};
DE EC=4.2.1.75 {ECO:0000256|ARBA:ARBA00013109, ECO:0000256|RuleBase:RU366031};
GN OrderedLocusNames=CP_0231 {ECO:0000313|EMBL:AAF38097.1}, CPn_0522
GN {ECO:0000313|EMBL:AAD18662.1};
GN ORFNames=BN1224_GiD_A_05440 {ECO:0000313|EMBL:CRI41543.1},
GN BN1224_H12_EE_00280 {ECO:0000313|EMBL:CRI43770.1},
GN BN1224_Panola_H_00390 {ECO:0000313|EMBL:CRI47141.1},
GN BN1224_U1271_C_03740 {ECO:0000313|EMBL:CRI49434.1};
OS Chlamydia pneumoniae (Chlamydophila pneumoniae).
OC Bacteria; Chlamydiota; Chlamydiia; Chlamydiales; Chlamydiaceae;
OC Chlamydia/Chlamydophila group; Chlamydia.
OX NCBI_TaxID=83558 {ECO:0000313|Proteomes:UP000000583};
RN [1] {ECO:0000313|EMBL:AAD18662.1, ECO:0000313|Proteomes:UP000000801}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CWL029 {ECO:0000313|EMBL:AAD18662.1,
RC ECO:0000313|Proteomes:UP000000801};
RX PubMed=10192388; DOI=10.1038/7716;
RA Kalman S., Mitchell W., Marathe R., Lammel C., Fan J., Hyman R.W.,
RA Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL Nat. Genet. 21:385-389(1999).
RN [2] {ECO:0000313|EMBL:AAF38097.1, ECO:0000313|Proteomes:UP000000583}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AR39 {ECO:0000313|EMBL:AAF38097.1,
RC ECO:0000313|Proteomes:UP000000583};
RX PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA Salzberg S.L., Eisen J.A., Fraser C.M.;
RT "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT AR39.";
RL Nucleic Acids Res. 28:1397-1406(2000).
RN [3] {ECO:0000313|EMBL:CRI41543.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GiD {ECO:0000313|EMBL:CRI41543.1}, H12
RC {ECO:0000313|EMBL:CRI43770.1}, Panola {ECO:0000313|EMBL:CRI47141.1},
RC and U1271 {ECO:0000313|EMBL:CRI49434.1};
RA Rattei Thomas;
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes cyclization of the linear tetrapyrrole,
CC hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
CC {ECO:0000256|ARBA:ARBA00037589, ECO:0000256|RuleBase:RU366031}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=hydroxymethylbilane = H2O + uroporphyrinogen III;
CC Xref=Rhea:RHEA:18965, ChEBI:CHEBI:15377, ChEBI:CHEBI:57308,
CC ChEBI:CHEBI:57845; EC=4.2.1.75;
CC Evidence={ECO:0000256|ARBA:ARBA00000783,
CC ECO:0000256|RuleBase:RU366031};
CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.
CC {ECO:0000256|ARBA:ARBA00004772, ECO:0000256|RuleBase:RU366031}.
CC -!- SIMILARITY: Belongs to the uroporphyrinogen-III synthase family.
CC {ECO:0000256|ARBA:ARBA00008133, ECO:0000256|RuleBase:RU366031}.
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DR EMBL; AE001363; AAD18662.1; -; Genomic_DNA.
DR EMBL; AE002161; AAF38097.1; -; Genomic_DNA.
DR EMBL; LN847008; CRI41543.1; -; Genomic_DNA.
DR EMBL; LN847184; CRI43770.1; -; Genomic_DNA.
DR EMBL; LN847233; CRI47141.1; -; Genomic_DNA.
DR EMBL; LN847244; CRI49434.1; -; Genomic_DNA.
DR PIR; A72068; A72068.
DR PIR; F86555; F86555.
DR RefSeq; NP_224718.1; NC_000922.1.
DR RefSeq; WP_010883160.1; NZ_LN847257.1.
DR AlphaFoldDB; Q9Z830; -.
DR SMR; Q9Z830; -.
DR STRING; 406984.CPK_ORF01036; -.
DR KEGG; cpa:CP_0231; -.
DR KEGG; cpn:CPn_0522; -.
DR PATRIC; fig|115713.3.peg.581; -.
DR eggNOG; COG1587; Bacteria.
DR HOGENOM; CLU_107939_0_0_0; -.
DR OrthoDB; 21594at2; -.
DR Proteomes; UP000000583; Chromosome.
DR Proteomes; UP000000801; Chromosome.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd06578; HemD; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR039793; UROS/Hem4.
DR PANTHER; PTHR38042; UROPORPHYRINOGEN-III SYNTHASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR38042:SF1; UROPORPHYRINOGEN-III SYNTHASE, CHLOROPLASTIC; 1.
DR Pfam; PF02602; HEM4; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU366031};
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244,
KW ECO:0000256|RuleBase:RU366031}.
FT DOMAIN 14..206
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
SQ SEQUENCE 223 AA; 25727 MW; 6F5467191757D19B CRC64;
MTLYLGLNQK TARKYQAHYL PILTLFPYAK STPQNKRALQ FLPQATHVIL TSPSSTHLFL
SRMTSLLSKA TLKTKTYLCI GESTKERLLS FLGQVKYVVA TQEIAEGIFP LLQALPSSAR
ILYPHSSLAR PVIREFLYNR FTFFSYPHYT VKPRKLKKNI LSKYKKIIFT SPSTVRAFAK
IFPRFPEKTY WCQGRMTLQE FQKFSSQKQV SLLETLGKSR TSP
//
