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Database: UniProt
Entry: Q9ZD95
LinkDB: Q9ZD95
Original site: Q9ZD95 
ID   UVRD_RICPR              Reviewed;         658 AA.
AC   Q9ZD95;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   05-DEC-2018, entry version 89.
DE   RecName: Full=Probable DNA helicase II homolog;
DE            EC=3.6.4.12;
GN   Name=uvrD; OrderedLocusNames=RP447;
OS   Rickettsia prowazekii (strain Madrid E).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX   NCBI_TaxID=272947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Madrid E;
RX   PubMed=9823893; DOI=10.1038/24094;
RA   Andersson S.G.E., Zomorodipour A., Andersson J.O.,
RA   Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K.,
RA   Eriksson A.-S., Winkler H.H., Kurland C.G.;
RT   "The genome sequence of Rickettsia prowazekii and the origin of
RT   mitochondria.";
RL   Nature 396:133-140(1998).
CC   -!- FUNCTION: Has both ATPase and helicase activities. Unwinds DNA
CC       duplexes with 3' to 5' polarity with respect to the bound strand
CC       and initiates unwinding most effectively when a single-stranded
CC       region is present. Involved in the post-incision events of
CC       nucleotide excision repair and methyl-directed mismatch repair (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC   -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC       {ECO:0000305}.
DR   EMBL; AJ235271; CAA14904.1; -; Genomic_DNA.
DR   PIR; F71703; F71703.
DR   RefSeq; NP_220828.1; NC_000963.1.
DR   RefSeq; WP_004599479.1; NC_000963.1.
DR   ProteinModelPortal; Q9ZD95; -.
DR   SMR; Q9ZD95; -.
DR   STRING; 272947.RP447; -.
DR   EnsemblBacteria; CAA14904; CAA14904; CAA14904.
DR   GeneID; 883357; -.
DR   KEGG; rpr:RP447; -.
DR   PATRIC; fig|272947.5.peg.460; -.
DR   eggNOG; ENOG4105C4R; Bacteria.
DR   eggNOG; COG0210; LUCA.
DR   HOGENOM; HOG000033016; -.
DR   KO; K03657; -.
DR   OMA; YQDTNRT; -.
DR   BioCyc; RPRO272947:G1GT0-449-MONOMER; -.
DR   Proteomes; UP000002480; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004003; F:ATP-dependent DNA helicase activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0006268; P:DNA unwinding involved in DNA replication; IEA:InterPro.
DR   Gene3D; 1.10.10.160; -; 1.
DR   InterPro; IPR005751; ATP-dep_DNA_helicase_PcrA.
DR   InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   InterPro; IPR034739; UvrD/AddA_N.
DR   PANTHER; PTHR11070; PTHR11070; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR01073; pcrA; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; DNA damage; DNA repair;
KW   DNA replication; DNA-binding; Helicase; Hydrolase; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN         1    658       Probable DNA helicase II homolog.
FT                                /FTId=PRO_0000102081.
FT   DOMAIN       12    293       UvrD-like helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00560}.
FT   DOMAIN      294    564       UvrD-like helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00617}.
FT   NP_BIND      36     41       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00560}.
FT   BINDING     291    291       ATP. {ECO:0000250}.
SQ   SEQUENCE   658 AA;  75389 MW;  CCFA97690F0E0BDC CRC64;
     MKDKIQNQNF MHTLNAEQKK AALHTEGPLL LLAGAGTGKT KVLTSRIANI IHQNLALPHN
     ILAVTFTNKA AKEMSERVHN LINCYGLNIG TFHSMAAKIL RDQIENLNLG FNNRFTIISH
     DDQLTLVKDI VKLKKDIDAK KYTPKLIHII ISRWKDQGLL PNKLSTSDTN LPLQKIAKLV
     YEEYQKNLLI SNVLDFGDLL LYNNELFIKN PAVLKYYQEK YRYILIDEYQ DTNIAQYLWA
     RMLASLYRNI CCVGDDDQSI YGWRGAEVGN ILRFEKDFAG ATIIKLEQNY RSTLPILAAA
     SNVINNNKNR HSKTLWTDSS SGEKIKIISC LSDKEEARYI ACEIDKLVKE ERYNAGNIAI
     LVRAGFQTRS FEEAFINSAI PYKIIGGLRF YERMEIRDVL AYIRISLNQN DNLALERIIN
     VPKRAIGAAS LNKIRSYALE RNISNFAAIK EILEIGNIKA KSYESLKDLL TKIDNWYEQF
     IIDTPINVVK AILDDSGYLA MLKEEKTEEA FGRIENINEM LRAIAEFNDI HDFIEYSSLV
     MENEVLETNY GGSVTIMTLH AAKGLEFDVV FLPGWEEGVF PSQRSLDEDG EKGLEEERRI
     AYVGITRAKK DLYITHAESR KIFYEIVRSC PSRFINEIPD EITIRTSSMK QYNSFYKF
//
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