ID Q9ZRP9_MALDO Unreviewed; 447 AA.
AC Q9ZRP9;
DT 01-MAY-1999, integrated into UniProtKB/TrEMBL.
DT 01-MAY-1999, sequence version 1.
DT 27-MAR-2024, entry version 108.
DE RecName: Full=Elongation factor 1-alpha {ECO:0000256|RuleBase:RU000325};
GN Name=eF-1alpha {ECO:0000313|EMBL:CAA11705.1};
GN ORFNames=DVH24_005965 {ECO:0000313|EMBL:RXH83712.1};
OS Malus domestica (Apple) (Pyrus malus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Maleae; Malus.
OX NCBI_TaxID=3750 {ECO:0000313|EMBL:CAA11705.1};
RN [1] {ECO:0000313|EMBL:CAA11705.1}
RP NUCLEOTIDE SEQUENCE.
RA Watillon B., Kettmann R., Boxus P., Burny A.;
RT "Developmentally- and environmentally-induced modifications of elongation
RT factor 1alpha (EF-1alpha) transcript levels in apple plants.";
RL Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:RXH83712.1, ECO:0000313|Proteomes:UP000290289}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. HFTH1 {ECO:0000313|Proteomes:UP000290289};
RC TISSUE=Young leaf {ECO:0000313|EMBL:RXH83712.1};
RA Hu J.;
RT "A high-quality apple genome assembly.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein promotes the GTP-dependent binding of aminoacyl-
CC tRNA to the A-site of ribosomes during protein biosynthesis.
CC {ECO:0000256|ARBA:ARBA00003982, ECO:0000256|RuleBase:RU000325}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A
CC subfamily. {ECO:0000256|ARBA:ARBA00007249,
CC ECO:0000256|RuleBase:RU000325}.
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DR EMBL; AJ223969; CAA11705.1; -; mRNA.
DR EMBL; RDQH01000337; RXH83712.1; -; Genomic_DNA.
DR RefSeq; NP_001280807.1; NM_001293878.1.
DR RefSeq; XP_008349742.1; XM_008351520.2.
DR RefSeq; XP_008366354.1; XM_008368132.2.
DR AlphaFoldDB; Q9ZRP9; -.
DR STRING; 3750.Q9ZRP9; -.
DR EnsemblPlants; mRNA:MD11G0103400; mRNA:MD11G0103400; MD11G0103400.
DR GeneID; 103447859; -.
DR Gramene; mRNA:MD11G0103400; mRNA:MD11G0103400; MD11G0103400.
DR KEGG; mdm:103447859; -.
DR OrthoDB; 5477300at2759; -.
DR Proteomes; UP000290289; Chromosome 11.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-UniRule.
DR CDD; cd01883; EF1_alpha; 1.
DR CDD; cd03693; EF1_alpha_II; 1.
DR CDD; cd03705; EF1_alpha_III; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR HAMAP; MF_00118_A; EF_Tu_A; 1.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004539; Transl_elong_EF1A_euk/arc.
DR InterPro; IPR004160; Transl_elong_EFTu/EF1A_C.
DR NCBIfam; TIGR00483; EF-1_alpha; 1.
DR PANTHER; PTHR23115:SF306; ELONGATION FACTOR 1-ALPHA; 1.
DR PANTHER; PTHR23115; TRANSLATION FACTOR; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF03143; GTP_EFTU_D3; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 2: Evidence at transcript level;
KW Elongation factor {ECO:0000256|RuleBase:RU000325,
KW ECO:0000313|EMBL:CAA11705.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU000325};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU000325};
KW Protein biosynthesis {ECO:0000256|RuleBase:RU000325,
KW ECO:0000313|EMBL:CAA11705.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000290289}.
FT DOMAIN 5..230
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 447 AA; 49481 MW; EC1D57D36898DC13 CRC64;
MGKEKFHINI VVIGHVDSGK STTTGHLIYK LGGIDKRVIE RFEKEAAEMN KRSFKYAWVL
DKLKAERERG ITIDIALWKF ETTKYYCTVI DAPGHRDFIK NMITGTSQAD CAILIIDSTT
GGFEAGISKD GQTREHALLA FTLGVRQMIC CCNKMDATTP KYSRARYDEI VKEVSSYLKK
VGYNPDKIPF VPISGFEGDN MIERSTNLDW YKGPTLLEAL DQINEPKRPS DKPLRLPLQD
VYKIGGIGTV PVGRVETGVI KPGMVVTFGP TGLTTEVKSV EMHHEAMQEA LPGDNVGFNV
KNVAVKDLKR GYVASNSKDD PAKEAANFIA QVIIMNHPGQ IGQGYAPVLD CHTSHIAVKF
AELVTKIDRR SGKELEKEPK FLKNGDAGFV KMLPTKPMVV ETFSEYPPLG RFAVRDMRQT
VAVGVIKSVE KKDPTGAKIT KAAAKKK
//
