GenomeNet

Database: UniProt
Entry: Q9ZUM9
LinkDB: Q9ZUM9
Original site: Q9ZUM9 
ID   ASHR2_ARATH             Reviewed;         398 AA.
AC   Q9ZUM9; Q84WB9; Q94CD2;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 3.
DT   13-FEB-2019, entry version 112.
DE   RecName: Full=Histone-lysine N-methyltransferase ASHR2;
DE            EC=2.1.1.43;
DE   AltName: Full=ASH1-related protein 2;
DE   AltName: Full=Protein SET DOMAIN GROUP 39;
GN   Name=ASHR2; Synonyms=SDG39, SET39; OrderedLocusNames=At2g19640;
GN   ORFNames=F3P11.24;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC   Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
OC   Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L.,
RA   Moffat K.S., Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L.,
RA   Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H.,
RA   Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D.,
RA   Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M.,
RA   Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis
RT   thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana
RT   reference genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
RA   Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
RA   Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
RA   Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
RA   Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
RA   Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
RA   Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
RA   Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
RA   Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
RA   Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
RA   Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
RA   Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   NOMENCLATURE.
RX   PubMed=11691919; DOI=10.1093/nar/29.21.4319;
RA   Baumbusch L.O., Thorstensen T., Krauss V., Fischer A., Naumann K.,
RA   Assalkhou R., Schulz I., Reuter G., Aalen R.B.;
RT   "The Arabidopsis thaliana genome contains at least 29 active genes
RT   encoding SET domain proteins that can be assigned to four
RT   evolutionarily conserved classes.";
RL   Nucleic Acids Res. 29:4319-4333(2001).
CC   -!- FUNCTION: Histone methyltransferase. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) +
CC         N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:10024, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:9846,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.43;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome
CC       {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9ZUM9-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9ZUM9-2; Sequence=VSP_018134, VSP_018135;
CC         Note=No experimental confirmation available.;
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. Histone-lysine methyltransferase
CC       family. SET2 subfamily. {ECO:0000255|PROSITE-ProRule:PRU00190}.
DR   EMBL; AC005917; AAD10162.2; -; Genomic_DNA.
DR   EMBL; CP002685; AEC06906.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC06907.1; -; Genomic_DNA.
DR   EMBL; AY034953; AAK59459.1; -; mRNA.
DR   EMBL; AY070027; AAL47498.1; -; mRNA.
DR   EMBL; BT004010; AAO42047.1; -; mRNA.
DR   PIR; C84579; C84579.
DR   RefSeq; NP_565457.1; NM_127522.2. [Q9ZUM9-2]
DR   RefSeq; NP_849991.1; NM_179660.2. [Q9ZUM9-1]
DR   UniGene; At.23821; -.
DR   ProteinModelPortal; Q9ZUM9; -.
DR   SMR; Q9ZUM9; -.
DR   BioGrid; 1838; 1.
DR   STRING; 3702.AT2G19640.2; -.
DR   PaxDb; Q9ZUM9; -.
DR   EnsemblPlants; AT2G19640.1; AT2G19640.1; AT2G19640. [Q9ZUM9-2]
DR   EnsemblPlants; AT2G19640.2; AT2G19640.2; AT2G19640. [Q9ZUM9-1]
DR   GeneID; 816483; -.
DR   Gramene; AT2G19640.1; AT2G19640.1; AT2G19640. [Q9ZUM9-2]
DR   Gramene; AT2G19640.2; AT2G19640.2; AT2G19640. [Q9ZUM9-1]
DR   KEGG; ath:AT2G19640; -.
DR   Araport; AT2G19640; -.
DR   TAIR; locus:2050434; AT2G19640.
DR   eggNOG; KOG2084; Eukaryota.
DR   eggNOG; COG2940; LUCA.
DR   HOGENOM; HOG000242635; -.
DR   InParanoid; Q9ZUM9; -.
DR   KO; K11426; -.
DR   OMA; VLECNVC; -.
DR   OrthoDB; 981799at2759; -.
DR   PhylomeDB; Q9ZUM9; -.
DR   PRO; PR:Q9ZUM9; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   Genevisible; Q9ZUM9; AT.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR001214; SET_dom.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   PROSITE; PS50280; SET; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Chromatin regulator; Chromosome;
KW   Complete proteome; Methyltransferase; Nucleus; Reference proteome;
KW   S-adenosyl-L-methionine; Transferase.
FT   CHAIN         1    398       Histone-lysine N-methyltransferase ASHR2.
FT                                /FTId=PRO_0000233375.
FT   DOMAIN       11    270       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
FT   COMPBIAS     53    184       Ser-rich.
FT   COMPBIAS    299    335       Glu-rich.
FT   VAR_SEQ     330    341       GENEEEVCGNGV -> DICVRRRIVLAL (in isoform
FT                                2). {ECO:0000303|PubMed:14593172}.
FT                                /FTId=VSP_018134.
FT   VAR_SEQ     342    398       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:14593172}.
FT                                /FTId=VSP_018135.
SQ   SEQUENCE   398 AA;  43761 MW;  32CFC10C8B546F64 CRC64;
     MINDGGAKPE TLLRVAEIGG RGRSLVAAQS LRAGQVILRE SPLLLYSAFP FLSSSVSPYC
     DHCFRLLASS AHQKCQSCSL VSFCSPNCFA SHTPWLCESL RRLHQSSSSA FSDQPSDRQV
     QARFLLSAYN LAAASPSDFQ ILLSLQGSGS SNGDPSCSAG DSAAAGFLHS LLSSVCPSLP
     VSISPDLTAA LLSKDKVNAF GLMEPCSVSN EKRSVRAYGI YPKTSFFNHD CLPNACRFDY
     VDSASDGNTD IIIRMIHDVP EGREVCLSYF PVNMNYSSRQ KRLLEDYGFK CDCDRCKVEF
     SWSEGEEDEN EIMEEMEDQD EQEEMEDSVG ENEEEVCGNG VDDESNFPHA YFFVRYMCEK
     ENCFGTLAPL PPKTHDASRV LECNVCGSVK EDEVGVNQ
//
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