ID ARR7_ARATH Reviewed; 206 AA.
AC Q9ZWS7;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 24-JAN-2024, entry version 153.
DE RecName: Full=Two-component response regulator ARR7;
GN Name=ARR7; OrderedLocusNames=At1g19050; ORFNames=F14D16.20;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=cv. Columbia;
RX PubMed=9482949; DOI=10.1073/pnas.95.5.2691;
RA Imamura A., Hanaki N., Umeda H., Nakamura A., Suzuki T., Ueguchi C.,
RA Mizuno T.;
RT "Response regulators implicated in His-to-Asp phosphotransfer signaling in
RT Arabidopsis.";
RL Proc. Natl. Acad. Sci. U.S.A. 95:2691-2696(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP INDUCTION.
RX PubMed=9662428; DOI=10.1016/s0014-5793(98)00611-5;
RA Taniguchi M., Kiba T., Sakakibara H., Ueguchi C., Mizuno T., Sugiyama T.;
RT "Expression of Arabidopsis response regulator homologs is induced by
RT cytokinins and nitrate.";
RL FEBS Lett. 429:259-262(1998).
RN [5]
RP TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=11115887; DOI=10.1104/pp.124.4.1706;
RA D'Agostino I.B., Deruere J., Kieber J.J.;
RT "Characterization of the response of the Arabidopsis response regulator
RT gene family to cytokinin.";
RL Plant Physiol. 124:1706-1717(2000).
RN [6]
RP FUNCTION.
RX PubMed=14973166; DOI=10.1105/tpc.018978;
RA To J.P.C., Haberer G., Ferreira F.J., Deruere J., Mason M.G.,
RA Schaller G.E., Alonso J.M., Ecker J.R., Kieber J.J.;
RT "Type-A Arabidopsis response regulators are partially redundant negative
RT regulators of cytokinin signaling.";
RL Plant Cell 16:658-671(2004).
CC -!- FUNCTION: Functions as a response regulator involved in His-to-Asp
CC phosphorelay signal transduction system. Phosphorylation of the Asp
CC residue in the receiver domain activates the ability of the protein to
CC promote the transcription of target genes. Type-A response regulators
CC seem to act as negative regulators of the cytokinin signaling.
CC {ECO:0000269|PubMed:14973166, ECO:0000269|PubMed:9482949}.
CC -!- INTERACTION:
CC Q9ZWS7; Q9ZNV8: AHP2; NbExp=6; IntAct=EBI-1100917, EBI-1100687;
CC Q9ZWS7; Q9SAZ5: AHP3; NbExp=4; IntAct=EBI-1100917, EBI-1100711;
CC Q9ZWS7; Q67XQ1: At1g03430; NbExp=3; IntAct=EBI-1100917, EBI-1100725;
CC Q9ZWS7; Q8L831: NUDT3; NbExp=2; IntAct=EBI-1100917, EBI-1807753;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Predominantly expressed in roots and young flowers.
CC {ECO:0000269|PubMed:11115887, ECO:0000269|PubMed:9482949}.
CC -!- INDUCTION: By cytokinins (BA and zeatin) and nitrate.
CC {ECO:0000269|PubMed:11115887, ECO:0000269|PubMed:9662428}.
CC -!- PTM: Two-component system major event consists of a His-to-Asp
CC phosphorelay between a sensor histidine kinase (HK) and a response
CC regulator (RR). In plants, the His-to-Asp phosphorelay involves an
CC additional intermediate named Histidine-containing phosphotransfer
CC protein (HPt). This multistep phosphorelay consists of a His-Asp-His-
CC Asp sequential transfer of a phosphate group between first an His and
CC an Asp of the HK protein, followed by the transfer to a conserved His
CC of the HPt protein and finally the transfer to an Asp in the receiver
CC domain of the RR protein.
CC -!- SIMILARITY: Belongs to the ARR family. Type-A subfamily. {ECO:0000305}.
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DR EMBL; AB008490; BAA34729.1; -; mRNA.
DR EMBL; AC068602; AAF79300.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE29795.1; -; Genomic_DNA.
DR PIR; T50854; T50854.
DR RefSeq; NP_173339.1; NM_101763.3.
DR AlphaFoldDB; Q9ZWS7; -.
DR SMR; Q9ZWS7; -.
DR BioGRID; 23726; 19.
DR IntAct; Q9ZWS7; 18.
DR STRING; 3702.Q9ZWS7; -.
DR PaxDb; 3702-AT1G19050-1; -.
DR EnsemblPlants; AT1G19050.1; AT1G19050.1; AT1G19050.
DR GeneID; 838487; -.
DR Gramene; AT1G19050.1; AT1G19050.1; AT1G19050.
DR KEGG; ath:AT1G19050; -.
DR Araport; AT1G19050; -.
DR TAIR; AT1G19050; ARR7.
DR eggNOG; KOG1601; Eukaryota.
DR HOGENOM; CLU_000445_69_5_1; -.
DR InParanoid; Q9ZWS7; -.
DR OMA; CVINPLR; -.
DR OrthoDB; 676715at2759; -.
DR PhylomeDB; Q9ZWS7; -.
DR PRO; PR:Q9ZWS7; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9ZWS7; baseline and differential.
DR Genevisible; Q9ZWS7; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0000156; F:phosphorelay response regulator activity; ISS:TAIR.
DR GO; GO:0009736; P:cytokinin-activated signaling pathway; IMP:TAIR.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; TAS:TAIR.
DR GO; GO:0009735; P:response to cytokinin; IEP:TAIR.
DR GO; GO:0019827; P:stem cell population maintenance; IMP:TAIR.
DR CDD; cd17581; REC_typeA_ARR; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR InterPro; IPR045279; ARR-like.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR43874; TWO-COMPONENT RESPONSE REGULATOR; 1.
DR PANTHER; PTHR43874:SF122; TWO-COMPONENT RESPONSE REGULATOR ARR7; 1.
DR Pfam; PF00072; Response_reg; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 1: Evidence at protein level;
KW Cytokinin signaling pathway; Nucleus; Phosphoprotein; Reference proteome;
KW Transcription; Transcription regulation; Two-component regulatory system.
FT CHAIN 1..206
FT /note="Two-component response regulator ARR7"
FT /id="PRO_0000081428"
FT DOMAIN 25..152
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT REGION 165..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 165..195
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 85
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 206 AA; 22800 MW; D13D14A540014DEB CRC64;
MAVGEVMRME IPAGGDLTVT TPELHVLAVD DSIVDRKVIE RLLRISSCKV TTVESGTRAL
QYLGLDGGKG ASNLKDLKVN LIVTDYSMPG LSGYDLLKKI KESSAFREVP VVIMSSENIL
PRIQECLKEG AEEFLLKPVK LADVKRIKQL IMRNEAEECK ILSHSNKRKL QEDSDTSSSS
HDDTSIKDSS CSKRMKSESE NLFSLL
//
