ID R0C0D0_9FIRM Unreviewed; 475 AA.
AC R0C0D0;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Efflux transporter, RND family, MFP subunit {ECO:0000313|EMBL:ENZ49912.1};
GN ORFNames=HMPREF1085_02618 {ECO:0000313|EMBL:ENZ49912.1};
OS Enterocloster bolteae 90A9.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Enterocloster.
OX NCBI_TaxID=997894 {ECO:0000313|EMBL:ENZ49912.1, ECO:0000313|Proteomes:UP000013126};
RN [1] {ECO:0000313|EMBL:ENZ49912.1, ECO:0000313|Proteomes:UP000013126}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=90A9 {ECO:0000313|EMBL:ENZ49912.1,
RC ECO:0000313|Proteomes:UP000013126};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Courvalin P., Lambert T.,
RA Walker B., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B.,
RA Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Larimer J., McCowan C., Murphy C., Neiman D., Pearson M.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Clostridium bolteae 90A9.";
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ENZ49912.1}.
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DR EMBL; AGYH01000006; ENZ49912.1; -; Genomic_DNA.
DR RefSeq; WP_002569835.1; NZ_KB851182.1.
DR AlphaFoldDB; R0C0D0; -.
DR GeneID; 61860929; -.
DR PATRIC; fig|997894.4.peg.2761; -.
DR HOGENOM; CLU_018816_14_5_9; -.
DR OrthoDB; 9777308at2; -.
DR Proteomes; UP000013126; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30469:SF33; EFFLUX PROTEIN; 1.
DR PANTHER; PTHR30469; MULTIDRUG RESISTANCE PROTEIN MDTA; 1.
DR Pfam; PF13533; Biotin_lipoyl_2; 1.
DR Pfam; PF13437; HlyD_3; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 76..93
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 130..174
FT /note="Membrane fusion protein biotin-lipoyl like"
FT /evidence="ECO:0000259|Pfam:PF13533"
FT REGION 1..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 225..279
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 20..43
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 475 AA; 51281 MW; 973E08450F1CA4A1 CRC64;
MGTEKKAGDL EEIQVLEGIS ESEEIDRRVE ELMAPEEEGN GKKKKKKQKQ KTGHRSSEGG
FHPVRRFKGF SRKRKIITVL VLAAVVLFGF SRMSGGKKDL GIPVAVMPLA KQDVQEKLTV
SGPVSGTDSV DVVSNIHAEI TAMNVKEGDT VTKGQVLAVV DSTDLEREVQ IAQNAYDLAV
ANKQEKDKEA ALGYEKAVQD FQKASLDHSR NSQLFATGDI SQMELEASAN ALNDARRQME
GYTVENGRGV ADSSYGIQIQ NAAFDLEKKK EELDNTQIKS TIDGTVVRVN SKVGQFADKV
EDDKPILSIE NLEQLELEIK VSEFSIGKVK VGQMATITAD ILDGETAEGE VVKISPTGEE
KGGGSTERVI PTTIRVDGGS SKLIAGITAK AELLIREAKD VFVVPSSALF DDGEVTYIAI
VQDMKVKRIP VTMGVDGDVV VEVIPTDGTV LEEGMQVITN PGPHLMDGAA VLITQ
//
