ID R0F8F2_9BRAS Unreviewed; 1255 AA.
AC R0F8F2;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=MutL C-terminal dimerisation domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CARUB_v10006691mg {ECO:0000313|EMBL:EOA18207.1};
OS Capsella rubella.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Capsella.
OX NCBI_TaxID=81985 {ECO:0000313|EMBL:EOA18207.1, ECO:0000313|Proteomes:UP000029121};
RN [1] {ECO:0000313|Proteomes:UP000029121}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Monte Gargano {ECO:0000313|Proteomes:UP000029121};
RX PubMed=23749190; DOI=10.1038/ng.2669;
RA Slotte T., Hazzouri K.M., Agren J.A., Koenig D., Maumus F., Guo Y.L.,
RA Steige K., Platts A.E., Escobar J.S., Newman L.K., Wang W., Mandakova T.,
RA Vello E., Smith L.M., Henz S.R., Steffen J., Takuno S., Brandvain Y.,
RA Coop G., Andolfatto P., Hu T.T., Blanchette M., Clark R.M., Quesneville H.,
RA Nordborg M., Gaut B.S., Lysak M.A., Jenkins J., Grimwood J., Chapman J.,
RA Prochnik S., Shu S., Rokhsar D., Schmutz J., Weigel D., Wright S.I.;
RT "The Capsella rubella genome and the genomic consequences of rapid mating
RT system evolution.";
RL Nat. Genet. 45:831-835(2013).
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; KB870811; EOA18207.1; -; Genomic_DNA.
DR RefSeq; XP_006285309.1; XM_006285247.1.
DR AlphaFoldDB; R0F8F2; -.
DR STRING; 81985.R0F8F2; -.
DR eggNOG; KOG1977; Eukaryota.
DR Proteomes; UP000029121; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF47; DNA MISMATCH REPAIR PROTEIN MLH3; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Reference proteome {ECO:0000313|Proteomes:UP000029121}.
FT DOMAIN 212..354
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 1023..1183
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
SQ SEQUENCE 1255 AA; 141279 MW; 0E064F5C8B5F2027 CRC64;
MKTIKPLPEG VRHSMRSGII MFDITRVVEE LVFNSLDAGA TKVSIFVGVV SCSVKVVDDG
SGVSRDDLVL LGERYASSKF HDLETASETF GFRGEALASI SDISLLEIRT KAIGRPNGYR
KVIKGSKCLH LGIDDDRKVS GTTVTVRDLF YNQPVRRKYM QSSPKKLLES IKKCVFRIAL
VHSNVSFSVL DIESDEELFQ TNPSSSAFSL LMRDAEKEAL NPLCKVNVTD SMLTVSGYIS
GPGDSFKALQ YICIHICASS SIDINSRFIS KGPIHKLLYN LAASFENTDS WKPPDELQTG
RRNRLQSNPG YILCITCPRH LYEFSFEPSK THVEFKNWEP ILAFIRRIIL ANWKKDTSLE
FFDGGADLLP KGDIQDLRLR EGTKTFILSP FYHISASLLR RTIYGSSNLN IPGKSLSMCH
LLDADWPEAM EPTKKKLKRS NDKAPCSFLL SPAAELKRDG VFLSEGKDER SVQYKFDMDI
ENLKEQGSEF DCQTDSLPQS CDMDFPQVTD LLKTSFVAGV TCSKQSLKRC QSSTPLNIDN
DFRKDSDELN QQFGGYKDEL NVSNFTGKHL LRGYSSGESL ILNKPIRTHD ERSELAMPMI
LNNDQCNSLI RVLETREGGS QSDIFSDTLE CHGTTRTLDC SLGSSWQDTD WFTLQRPAYS
GSGREDFNIA SIDTVEFHSY KDKIFGKKYF SSVNVGSSGA ESFCLSSELS PMFSTPPSAT
KWELDYQKGC QILEGSLRLG RMIDPEFLFS AADNIEFDHE VIPQMDCQET NTDSFTAIQN
FTQSDEKVCK SLWEHADNVG IELISIKRDK FNYRNVRQNN DGKQRSRRSR SAPPFYQDKK
RFISLNCRSD TKSKNSDPQG SYYWSLFPEC GTKDINEVYL SAEHDDLECL TQPCNTSHMY
PKRSIINDVS YDHIQETEES LNSASDLKAS TGCRTVHPET LEEDGDKDFS SKENVDLDKS
TTKWRHHCSV SQVIHIDKVA KESHELHDQD SVLDICSGLL HLRSDESLVP ESINRHSVED
ARVLQQVDKK YIPIVACGTL AIVDQHAADE RIRLEELRKK VLAGEARTVT YLNADQELVL
PEMGYQLLQS YSEQIRNWGW ICSINVEGST SFKKNMSIIQ RKPTPITLNA VPCILGVNLS
DVDLLEFLQQ LADTDGSSTI PPSVLRILNS KACRGAIMFG DSLLPSECSL IMEGLKQTSL
CFQCAHGRPT TVPLVNLKAL HKQITKLGSK QLWHGFHRRE ITLDRAKSRL EKARN
//
