ID R0FD99_9BRAS Unreviewed; 672 AA.
AC R0FD99;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=CARUB_v10000391mg {ECO:0000313|EMBL:EOA20112.1};
OS Capsella rubella.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Capsella.
OX NCBI_TaxID=81985 {ECO:0000313|EMBL:EOA20112.1, ECO:0000313|Proteomes:UP000029121};
RN [1] {ECO:0000313|Proteomes:UP000029121}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Monte Gargano {ECO:0000313|Proteomes:UP000029121};
RX PubMed=23749190; DOI=10.1038/ng.2669;
RA Slotte T., Hazzouri K.M., Agren J.A., Koenig D., Maumus F., Guo Y.L.,
RA Steige K., Platts A.E., Escobar J.S., Newman L.K., Wang W., Mandakova T.,
RA Vello E., Smith L.M., Henz S.R., Steffen J., Takuno S., Brandvain Y.,
RA Coop G., Andolfatto P., Hu T.T., Blanchette M., Clark R.M., Quesneville H.,
RA Nordborg M., Gaut B.S., Lysak M.A., Jenkins J., Grimwood J., Chapman J.,
RA Prochnik S., Shu S., Rokhsar D., Schmutz J., Weigel D., Wright S.I.;
RT "The Capsella rubella genome and the genomic consequences of rapid mating
RT system evolution.";
RL Nat. Genet. 45:831-835(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR EMBL; KB870810; EOA20112.1; -; Genomic_DNA.
DR RefSeq; XP_006287214.1; XM_006287152.1.
DR AlphaFoldDB; R0FD99; -.
DR STRING; 81985.R0FD99; -.
DR eggNOG; KOG0925; Eukaryota.
DR Proteomes; UP000029121; Unassembled WGS sequence.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR CDD; cd17973; DEXHc_DHX15; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR044756; DHX15_DEXHc.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF228; RNA HELICASE; 1.
DR Pfam; PF13401; AAA_22; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Reference proteome {ECO:0000313|Proteomes:UP000029121};
KW Spliceosome {ECO:0000256|ARBA:ARBA00022728}.
FT DOMAIN 42..201
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 226..392
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 672 AA; 77337 MW; AD4562961197DFDD CRC64;
MNPYPKRKIR IETTKKTYSA RYVEILEKWK KLPVWVHKEE FLKTLKENQI VLLVGETGSG
KTTQIPQFVL EAKWLVGCTQ PRRVAAMSVS RRVAEEMDVE IGEEVGYTVR FEDCTSSKTV
LKYLTDGMLL REAMADPLLG RYKVIVLDEA HERTLATYLL FGLLKQTLVR RPDLKLVVMS
ATLEADKFHK YFTGVPLIKV PGRLHPVEIL YTREPQRDYL EAAISTVIQI HMCEPPGDVL
VFLTGEEEIE DACRRITRNL GDHVNVLPLY STLSPAMQQK IFEPTPDQVR KVVVSTNIAE
TSLTIDGIVY VVDPGFSKQK LYHPDTRVES LLVSPISQAS ADQSAGRAGR TRPGKCFRLY
AEKSFNELEK QTYAEILRSN LANTVLNLKR LGVENLLRFD LMDSPAPETL ARALDDLYHL
QALDDECNLT KTGEMMSEFP LDPQMAKMLI VSPQFNCSNE ILSISAMLSV PNCFIRPRGE
AQKAADEAKS SFAHIYGDHL TLLNVFHAFL QNNQDPDWCY ENFINYRKMK SAVSVREQLV
RIMLRFQIKL CSPDFNSKDY YVNIRKALLS GYFMQVAHLE RTGHYLTFRD KDDQVVHLHP
SNCLDHKAEW VIYNEYVFTT RNFIRTVTYI RGEWLVDVAP HYYKLANFPN SEAKRVLQRH
FKKRRLSEER SC
//
