ID R0GUH7_9BRAS Unreviewed; 939 AA.
AC R0GUH7;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=AP-4 complex subunit epsilon {ECO:0000256|PIRNR:PIRNR037097};
GN ORFNames=CARUB_v10008229mg {ECO:0000313|EMBL:EOA39602.1};
OS Capsella rubella.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Capsella.
OX NCBI_TaxID=81985 {ECO:0000313|EMBL:EOA39602.1, ECO:0000313|Proteomes:UP000029121};
RN [1] {ECO:0000313|Proteomes:UP000029121}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Monte Gargano {ECO:0000313|Proteomes:UP000029121};
RX PubMed=23749190; DOI=10.1038/ng.2669;
RA Slotte T., Hazzouri K.M., Agren J.A., Koenig D., Maumus F., Guo Y.L.,
RA Steige K., Platts A.E., Escobar J.S., Newman L.K., Wang W., Mandakova T.,
RA Vello E., Smith L.M., Henz S.R., Steffen J., Takuno S., Brandvain Y.,
RA Coop G., Andolfatto P., Hu T.T., Blanchette M., Clark R.M., Quesneville H.,
RA Nordborg M., Gaut B.S., Lysak M.A., Jenkins J., Grimwood J., Chapman J.,
RA Prochnik S., Shu S., Rokhsar D., Schmutz J., Weigel D., Wright S.I.;
RT "The Capsella rubella genome and the genomic consequences of rapid mating
RT system evolution.";
RL Nat. Genet. 45:831-835(2013).
CC -!- FUNCTION: Subunit of novel type of clathrin- or non-clathrin-associated
CC protein coat involved in targeting proteins from the trans-Golgi
CC network (TGN) to the endosomal-lysosomal system.
CC {ECO:0000256|PIRNR:PIRNR037097}.
CC -!- SUBUNIT: Adaptor protein complex 4 (AP-4) is a heterotetramer composed
CC of two large adaptins, a medium adaptin and a small adaptin.
CC {ECO:0000256|PIRNR:PIRNR037097}.
CC -!- SIMILARITY: Belongs to the adaptor complexes large subunit family.
CC {ECO:0000256|PIRNR:PIRNR037097}.
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DR EMBL; KB870805; EOA39602.1; -; Genomic_DNA.
DR RefSeq; XP_006306704.1; XM_006306642.1.
DR AlphaFoldDB; R0GUH7; -.
DR STRING; 81985.R0GUH7; -.
DR GeneID; 17898897; -.
DR KEGG; crb:17898897; -.
DR eggNOG; KOG1062; Eukaryota.
DR OrthoDB; 25313at2759; -.
DR Proteomes; UP000029121; Unassembled WGS sequence.
DR GO; GO:0030124; C:AP-4 adaptor complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR017109; AP4_complex_esu.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR PANTHER; PTHR22780; ADAPTIN, ALPHA/GAMMA/EPSILON; 1.
DR PANTHER; PTHR22780:SF13; AP-4 COMPLEX SUBUNIT EPSILON-1; 1.
DR Pfam; PF01602; Adaptin_N; 1.
DR PIRSF; PIRSF037097; AP4_complex_epsilon; 3.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|PIRNR:PIRNR037097};
KW Membrane {ECO:0000256|PIRNR:PIRNR037097};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR037097};
KW Reference proteome {ECO:0000313|Proteomes:UP000029121};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR037097}.
FT DOMAIN 60..594
FT /note="Clathrin/coatomer adaptor adaptin-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01602"
FT REGION 692..868
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 886..939
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 695..709
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 726..764
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 886..908
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 922..939
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 939 AA; 103852 MW; 608C10C29EDD0090 CRC64;
MEQLKTIGRE LAMGSQGGFG QSKEFLDLVK SIGEARSKAE EDRIVLSEID ILKRRLLEPD
VPKRKMKEYI IRLVYIEMLG HDASFGYIHA VKMTHDDNLL LKRTGYLAVT LFLNEDHDLI
ILIVNTIQKD LRSDNYLVVC AALNAICRLI NEETIPAVLP QVVELLNHQK EAVRKKAIMA
LHRFHRKSPS SVSHLISNFR KRLCDNDPGV MGATLCPLFD LISEDVNSYK DLVSSFVSIL
KQVTERRLPK SYDYHSMPAP FIQIKLLKIL ALLGSGDKNA SEIMSMVLGD LFRKCDSSTN
IGNAILYECI RCISCILPNP KLLEAAADAI SKFLKSDSHN LKYMGIDGLG RLIKISPDIA
EQHQLAVIDC LEDPDDTLKR KTFELLYKMT KSSNVEVIVD RMIDYMISIN DNHYKTEIAS
RCVELAEQFA PSNQWFIQIM NKVFEHAGDL VNIKVAHNLM RLIAEGFGED DDDADSKLRL
SAVESYLQLI SEPKLPSLFL QVISWVLGEY GTADGKYSAS YISGKLCDVA DAYSSDETVK
GYAVSALMKI YAFEIASGRK VDVLPECQSL IEELLASHST DLQQRAYELQ ALLALDARAV
ETIIPLDASC EDIEVDKELS FLNGYIQQAI ESGSQPYISE RERLGMFETT DYHSQDHHEV
PSHALRFEAY ELPKPSVPPQ ASTELVPVPE PSYYSESHQP ISTSLVSERE SSEIKLRLDG
VKQKWGRPSY QSTTSASSTT QQAPNGTTSH SDAGVGSSSS KPRSSYEPKK PEIDPEKQRL
AASLFGGSSS SRTDKKSSSS GHKSAKGTVN KPATIPKEIP TPVQPPPDLL DLGEPTATTI
STMDPFKELE GLMDSSSQDG GSTDVMGLYS DTAPVATTTS VDSLLSELSD SSKGNSHTYQ
SQTSKGPNTK EALEKDALVR QMGVNPTSQN PTLFKDLLG
//
