ID R0HDK1_9BRAS Unreviewed; 1282 AA.
AC R0HDK1;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN ORFNames=CARUB_v10003908mg {ECO:0000313|EMBL:EOA23115.1};
OS Capsella rubella.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Capsella.
OX NCBI_TaxID=81985 {ECO:0000313|EMBL:EOA23115.1, ECO:0000313|Proteomes:UP000029121};
RN [1] {ECO:0000313|Proteomes:UP000029121}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Monte Gargano {ECO:0000313|Proteomes:UP000029121};
RX PubMed=23749190; DOI=10.1038/ng.2669;
RA Slotte T., Hazzouri K.M., Agren J.A., Koenig D., Maumus F., Guo Y.L.,
RA Steige K., Platts A.E., Escobar J.S., Newman L.K., Wang W., Mandakova T.,
RA Vello E., Smith L.M., Henz S.R., Steffen J., Takuno S., Brandvain Y.,
RA Coop G., Andolfatto P., Hu T.T., Blanchette M., Clark R.M., Quesneville H.,
RA Nordborg M., Gaut B.S., Lysak M.A., Jenkins J., Grimwood J., Chapman J.,
RA Prochnik S., Shu S., Rokhsar D., Schmutz J., Weigel D., Wright S.I.;
RT "The Capsella rubella genome and the genomic consequences of rapid mating
RT system evolution.";
RL Nat. Genet. 45:831-835(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
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DR EMBL; KB870810; EOA23115.1; -; Genomic_DNA.
DR RefSeq; XP_006290217.1; XM_006290155.1.
DR STRING; 81985.R0HDK1; -.
DR GeneID; 17883186; -.
DR KEGG; crb:17883186; -.
DR eggNOG; ENOG502SI7S; Eukaryota.
DR OrthoDB; 1055564at2759; -.
DR Proteomes; UP000029121; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR045344; C-JID.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017:SF533; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF20160; C-JID; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00369; LRR_TYP; 5.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000029121};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 13..175
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1282 AA; 146000 MW; E53E7B538C5C1714 CRC64;
MASHSSSSSS AVWRTDVFVS FRGEDVRKTF VSHLFSELDR MGINAFRDDL DLQRGKSISP
ELGDAIKGSR FAIVVVSRNY AASSWCLDEL LKIMECEETI NQTVLPIFYE VDPSEVRSQR
GGIGEHVESH SDKEKVRKWK EALTKLASIS GEDSRNWRDE SKLIKKVVKD ISDQLVSTLY
DDSEGLIGMS SHMDFLHSMM SMEDEDVRMV GIWGMGGVGK TTIAKYLYNQ LSFRFQAHCF
MDNVKEVSNR YGVRRLQGEF LCRMFREREK EAWDSVSFRS MIKERLRHKR VLIVLDDVDR
SEQLNELVKE IDWFGPGSRI IVTTRDRHLL VSHGIDLVYK VRCLPKKEAL QLFSYYAFRN
EIIIPHGFQE LSVQAINYAS GLPLALRVLG CFLCRRSQKE WQSTLARLKT YPHSEIMDVL
RVSYDGLDEQ EKAIFLYISC FYNMKHVDYV IKILDLCGYA AAISITVLTE KSLIAVSNGC
IKMHDLLERM GRELVRLQAV NNPTQRLLLW DPEDICELLS ENSTGTQLVE GISLNLSEIS
EVFASDRAFE GLSNLKLLNF YDLSFDGETR LHLPDGLSNL PRKLRYLRWD GYPLKTMPSR
FCPDFLVELC ISNSNLEKLW DGIQPLRNLK KMDLTRCKYL VEIPDLSKAT NLEELNLSYS
QRLVEVTPSI KNLKRLSSFY LTNCIQLKNI PVGITLKSLE TLDMSGCSSL KRFPEICWNT
IRLYLSSTKI EELPSSISRL SYLVELDMSD CQRLRTLPSS VRHLVSLKSM NLDGCKHLEN
LPDTLQNLTS LETLEMSGCL NVNEFPRAAT NIELLRISET SIEEIPARIC NLSQLRSLDI
SENKRLKSLP VSISELRSLE KLKLSGCSLL ESFPPEICQT MSCLRWFDLD RTSIKELPEN
IGNLVALEVL QASKTVIRRA PWSIAKLSRL QLLAIGNSSY TPEGLLHSAC PPLSRFDDLR
ALSLSNMNMI EIPNSIGNLW NLLELDLSGN NFKFVPASIK RLTKLNRLNL NNCQRLQALP
DELPRGLLYI YIHGCTSLVS ISGCFNQCCL RNLVASNCYN LDQAARILIH RNMKLESAKP
EHSYFPGNDV PACFSHQVMG PSLNIRLPQS ESSDILGFSA CIMIGADGQY PMNSLKIHCT
CILKDADSCE LIIMDEVWYP DPKAFPKMCF GSDHLLLFSR TCMSMGAYNE ALFEFSIENT
GGSSSPLGEI KKCAVHLISF KDMMRESDRI QNSDLDLSKV FDEARVLNRR AYETEFLREP
PSPKRIKFHG TEFLHQPNVI RE
//
