ID R0I162_9BRAS Unreviewed; 645 AA.
AC R0I162;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Alpha-dioxygenase 1 {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=CARUB_v10013184mg {ECO:0000313|EMBL:EOA30078.1};
OS Capsella rubella.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Capsella.
OX NCBI_TaxID=81985 {ECO:0000313|EMBL:EOA30078.1, ECO:0000313|Proteomes:UP000029121};
RN [1] {ECO:0000313|Proteomes:UP000029121}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Monte Gargano {ECO:0000313|Proteomes:UP000029121};
RX PubMed=23749190; DOI=10.1038/ng.2669;
RA Slotte T., Hazzouri K.M., Agren J.A., Koenig D., Maumus F., Guo Y.L.,
RA Steige K., Platts A.E., Escobar J.S., Newman L.K., Wang W., Mandakova T.,
RA Vello E., Smith L.M., Henz S.R., Steffen J., Takuno S., Brandvain Y.,
RA Coop G., Andolfatto P., Hu T.T., Blanchette M., Clark R.M., Quesneville H.,
RA Nordborg M., Gaut B.S., Lysak M.A., Jenkins J., Grimwood J., Chapman J.,
RA Prochnik S., Shu S., Rokhsar D., Schmutz J., Weigel D., Wright S.I.;
RT "The Capsella rubella genome and the genomic consequences of rapid mating
RT system evolution.";
RL Nat. Genet. 45:831-835(2013).
CC -!- COFACTOR:
CC Name=heme b; Xref=ChEBI:CHEBI:60344;
CC Evidence={ECO:0000256|ARBA:ARBA00001970};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB870807; EOA30078.1; -; Genomic_DNA.
DR RefSeq; XP_006297180.1; XM_006297118.1.
DR AlphaFoldDB; R0I162; -.
DR STRING; 81985.R0I162; -.
DR GeneID; 17892716; -.
DR KEGG; crb:17892716; -.
DR eggNOG; KOG2408; Eukaryota.
DR OrthoDB; 1086441at2759; -.
DR Proteomes; UP000029121; Unassembled WGS sequence.
DR GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004601; F:peroxidase activity; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0031408; P:oxylipin biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR CDD; cd09818; PIOX_like; 1.
DR Gene3D; 1.10.640.10; Haem peroxidase domain superfamily, animal type; 1.
DR InterPro; IPR034815; A_dioxygenase.
DR InterPro; IPR019791; Haem_peroxidase_animal.
DR InterPro; IPR010255; Haem_peroxidase_sf.
DR InterPro; IPR037120; Haem_peroxidase_sf_animal.
DR PANTHER; PTHR11903:SF11; ALPHA-DIOXYGENASE 1; 1.
DR PANTHER; PTHR11903; PROSTAGLANDIN G/H SYNTHASE; 1.
DR Pfam; PF03098; An_peroxidase; 1.
DR SUPFAM; SSF48113; Heme-dependent peroxidases; 1.
DR PROSITE; PS50292; PEROXIDASE_3; 1.
PE 4: Predicted;
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Heme {ECO:0000256|PIRSR:PIRSR619791-2};
KW Iron {ECO:0000256|PIRSR:PIRSR619791-2};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022767};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR619791-2};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00022964};
KW Oxylipin biosynthesis {ECO:0000256|ARBA:ARBA00022767};
KW Reference proteome {ECO:0000313|Proteomes:UP000029121}.
FT BINDING 395
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000256|PIRSR:PIRSR619791-2"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EOA30078.1"
SQ SEQUENCE 645 AA; 73939 MW; D9BCDB9B5BF6695A CRC64;
PQKLKRMKLI TSLISSILLK FIHKDFHEIY SRMSLLDRLI LLVVHAVDKM VPWHKLPVFL
GLAYLEARRH LHQEYNLLNV GQTPVGTRFD PANFPYRTAD GKFNDPFNEG VGSQNSFFGR
NCPPVDQKTK LLRPDPMVVA TKLLGRRKFI DTGKQFNMIA ASWIQFMIHD WIDHLEDTHQ
IELVAPREVA NQCPLRSFRF FKTKEVPTGF FDIKTGSQNI RTPWWDSSVI YGSNSKTMDR
VRTYKDGKLK ISEETGLLLH DKDGIAISGD VRNSWVGVSA LQALFIKEHN AVCDALKDDD
NDLEDEDLYR HARLVTSAVI AKIHTIDWTT QLLKTDTLLA GMRANWYGVL GKKFKDSFGH
AGSSILGGVV GMKKPKNHGV PYSLTEDFAS VYRMHSLLPD QLQMRDIDDE PGTNKSLPLI
KEISMSHLIG LKGEQTMSQI GFTKLMVSMG HQASGALELM NYPLWFRDII PHDHNGQERS
DHVDLAALEI YRDRERSVPR YNDFRRAMFM IPITKWEDLT ADKDAIEVLD DVYDGDVEEL
DLLVGLMAEK KIKGFAISET AFYIFLLMAT RRLEADRFFT SDFNETVYTK KGLKWVNTTE
SLKDVFDRHY PEMTDKWMNS ESAFSVWDSP PVTKNPIPLY LRIPS
//
