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Database: UniProt
Entry: R0J168_SETT2
LinkDB: R0J168_SETT2
Original site: R0J168_SETT2 
ID   R0J168_SETT2            Unreviewed;      1115 AA.
AC   R0J168;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   05-JUN-2019, entry version 39.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   ORFNames=SETTUDRAFT_175540 {ECO:0000313|EMBL:EOA90521.1};
OS   Setosphaeria turcica (strain 28A) (Northern leaf blight fungus)
OS   (Exserohilum turcicum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Dothideomycetes; Pleosporomycetidae; Pleosporales; Pleosporineae;
OC   Pleosporaceae; Exserohilum.
OX   NCBI_TaxID=671987 {ECO:0000313|EMBL:EOA90521.1, ECO:0000313|Proteomes:UP000016935};
RN   [1] {ECO:0000313|EMBL:EOA90521.1, ECO:0000313|Proteomes:UP000016935}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=28A {ECO:0000313|Proteomes:UP000016935};
RX   PubMed=23236275; DOI=10.1371/journal.ppat.1003037;
RA   Ohm R.A., Feau N., Henrissat B., Schoch C.L., Horwitz B.A.,
RA   Barry K.W., Condon B.J., Copeland A.C., Dhillon B., Glaser F.,
RA   Hesse C.N., Kosti I., LaButti K., Lindquist E.A., Lucas S.,
RA   Salamov A.A., Bradshaw R.E., Ciuffetti L., Hamelin R.C., Kema G.H.J.,
RA   Lawrence C., Scott J.A., Spatafora J.W., Turgeon B.G.,
RA   de Wit P.J.G.M., Zhong S., Goodwin S.B., Grigoriev I.V.;
RT   "Diverse lifestyles and strategies of plant pathogenesis encoded in
RT   the genomes of eighteen Dothideomycetes fungi.";
RL   PLoS Pathog. 8:E1003037-E1003037(2012).
RN   [2] {ECO:0000313|EMBL:EOA90521.1, ECO:0000313|Proteomes:UP000016935}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=28A {ECO:0000313|Proteomes:UP000016935};
RX   PubMed=23357949; DOI=10.1371/journal.pgen.1003233;
RA   Condon B.J., Leng Y., Wu D., Bushley K.E., Ohm R.A., Otillar R.,
RA   Martin J., Schackwitz W., Grimwood J., MohdZainudin N., Xue C.,
RA   Wang R., Manning V.A., Dhillon B., Tu Z.J., Steffenson B.J.,
RA   Salamov A., Sun H., Lowry S., LaButti K., Han J., Copeland A.,
RA   Lindquist E., Barry K., Schmutz J., Baker S.E., Ciuffetti L.M.,
RA   Grigoriev I.V., Zhong S., Turgeon B.G.;
RT   "Comparative genome structure, secondary metabolite, and effector
RT   coding capacity across Cochliobolus pathogens.";
RL   PLoS Genet. 9:E1003233-E1003233(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
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DR   EMBL; KB908493; EOA90521.1; -; Genomic_DNA.
DR   RefSeq; XP_008022340.1; XM_008024149.1.
DR   STRING; 93612.XP_008022340.1; -.
DR   EnsemblFungi; EOA90521; EOA90521; SETTUDRAFT_175540.
DR   GeneID; 19401403; -.
DR   OrthoDB; 20210at2759; -.
DR   Proteomes; UP000016935; Unassembled WGS sequence.
DR   GO; GO:0043625; C:delta DNA polymerase complex; IEA:EnsemblFungi.
DR   GO; GO:0000784; C:nuclear chromosome, telomeric region; IEA:EnsemblFungi.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:1904161; P:DNA synthesis involved in UV-damage excision repair; IEA:EnsemblFungi.
DR   GO; GO:1903459; P:mitotic DNA replication lagging strand elongation; IEA:EnsemblFungi.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Complete proteome {ECO:0000313|Proteomes:UP000016935};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016935};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN      130    476       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      540    979       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN     1017   1091       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   REGION        1     66       Disordered. {ECO:0000256|MobiDB-lite:
FT                                R0J168}.
FT   REGION       77     96       Disordered. {ECO:0000256|MobiDB-lite:
FT                                R0J168}.
FT   COMPBIAS     15     30       Polar. {ECO:0000256|MobiDB-lite:R0J168}.
FT   COMPBIAS     31     47       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                R0J168}.
FT   COMPBIAS     48     66       Polar. {ECO:0000256|MobiDB-lite:R0J168}.
SQ   SEQUENCE   1115 AA;  126641 MW;  D6C3CAA301825A0E CRC64;
     MPGTVARAPA KRALAETSTT RTNVQTSPRS AKKLKVKDGK DRSRPPARTA NDSFNSSQAG
     PSQFEETLEQ MTRDMETLKK DNSESDQQWR RPPLPEDFNE MTHNLVFQQI EAEEGVLNGG
     KATVKLFGVT ETGHSVLLHV TGFQHYFYVA APINFHKEDC EPYKIFLESE CQKSFNQHAA
     VIASVQMCMR ENILRFQGNQ KSPYLKITVN DPKMINRVRM MVQKGNANYK RLWPAREDGI
     LTFDNIAYVL RFMIDTKVAG MCWVEVPAAK YRMINVRERH SNCQIEAQVH YSDLIAHQSE
     GEWAKLAPLR ILSFDIECAG RKGVFPEANV DPVIQIANVV TRYGEDKPFV RNVFCLDTVS
     PIVATQILSF QNEGDMLMKW RDFVEEADPD VIIGYNINNF DFPYLLDRAK HLKLQKFPYW
     SRLKTVQSKV ETSNFSSKQL GARDTKTTNT NGRLQLDLLQ LIQRDHQLRS YTLNSVCAHF
     LKEQKEDVHH SMITELFNGD SNSRRRLAVY CLKDAYLPQR LLDKLMCLVN YTEMARVTGV
     PFNYLLARGQ QVRFISQLFR KAIDHQLVVP DLPNQGDNGD QYEGATVIEP KRGYYKEPVA
     TLDFASLYPS IMQAHNLCYT TWLDKQTVEK LKMKKDEDYI VTPNGDMFCT AKTRKGLLTE
     ILEELLGARK RAKKELAVET DPFKKAVLNG RQLALKVSAN SVYGLTGATN GKLPCLAIAS
     STTSFGRQMI ERAKAEVEAK YNIANGYSHD AEVIYGDTDS VMVKFGTSEL AEAMRLGEEA
     ANYVTSKFLK PIKLEFEKVY FPYLLINKKR YAGLYWTNPN KWDKMDTKGI ETVRRDNCRL
     VQTVIETSLR MLLIDQDPEG AQEFVKETIA DLLQNKIDMS NLVITKALTK QEDKDGKGGY
     ANKQAHVELA ERMKKRDAGS APALGDRVAY VMVRAATGAK NFEKSEDPIY VLENNLPIDT
     RYYLDNQLAK PLGRIFEPIL GEKKAASLLT GEHTRSISVA APTMGGLMKF AKKTQTCMGC
     KKPLTAAHEK EGAVCENCRP RIPELYTKTL TKVSELEVRF SRLWTQCQRC QGSVHCEVIC
     ASRDCPIFYM RMKARKDVED AGKELVRFDK DAALW
//
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